{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:54:08Z","timestamp":1791572048812,"version":"4.3.4"},"reference-count":53,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin Municipality","doi-asserted-by":"publisher","award":["25JCYBJC01200"],"award-info":[{"award-number":["25JCYBJC01200"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Multisystem aging discordance may represent an early risk factor for cognitive decline, but prospective evidence in Chinese older adults is limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We constructed a blood-based Aging Discordance Index (ADI) and examined its 3-year association with cognitive function in a nationally representative Chinese cohort. ADI was derived from five routine biomarkers (creatinine, total cholesterol, C-reactive protein, mean corpuscular volume, and glycated hemoglobin).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were from the China Health and Retirement Longitudinal Study (CHARLS). ADI was calculated as the standard deviation of age-adjusted Z-scores. Cognitive function was assessed via orientation, calculation, drawing, and equated word recall in 2018 data. Survey-weighted linear regression adjusted for baseline cognition, sociodemographic, lifestyle, and clinical covariates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 1688 participants aged \u226560 years, higher ADI was independently associated with worse 3-year cognitive performance (fully adjusted \u03b2\u2009=\u2009-0.336, 95% CI: \u22120.598 to \u22120.075, p\u2009=\u20090.011) and greater cognitive decline (\u03b2\u2009=\u2009-0.326, 95% CI: \u22120.575 to \u22120.077, p\u2009=\u20090.010). To address potential bias due to loss to follow-up, we further applied linear mixed models (LMM) with random intercepts in an expanded sample of 2912 participants, which utilizes all available repeated measures. The ADI \u00d7 time interaction remained significant (\u03b2\u2009=\u2009\u20130.346, 95% CI: \u22120.580 to \u22120.112, p\u2009=\u20090.004), confirming the robustness of the primary findings against attrition bias.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A simple blood-based index of multisystem aging discordance independently predicts cognitive decline in Chinese older adults. ADI may offer a practical, low-cost tool for early risk stratification in community settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261494123","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T11:07:28Z","timestamp":1791457648000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Multisystem aging discordance and cognitive decline in Chinese older adults: A longitudinal study from CHARLS"],"prefix":"10.1177","author":[{"given":"Guanqun","family":"Hu","sequence":"first","affiliation":[{"name":"Tianjin Union Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[{"name":"Tianjin Union Medical Center"},{"name":"Tianjin Medical 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