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The current study presents the development of a critical component for a low-cost microscope whose goal is to confer an inexpensive solution for automated analysis of microscopic smears. A novel design methodology was developed to optimize the achieved solution. During the exploration of this methodology, it is asked: how can an additive-manufactured prototype be cost-effective for accurate examination of cervical cytology smears? To understand the effect on cost and tensile strength that infill density and perimeter wall count, tensile tests were conducted. These results combined with the developed methodology achieved the most cost-effective solution. To achieve this, topology optimization was used to improve the stiffness-per-weight ratio of different parts. Finally, design for additive manufacturing and topology optimization was proven as an effective design tool. <\/jats:p>","DOI":"10.1177\/14644207211022774","type":"journal-article","created":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T23:07:48Z","timestamp":1640041668000},"page":"267-279","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["<i>\u03bc<\/i>SmartScope \u2013 Towards a low-cost microscopic medical device for cervical cancer screening using additive manufacturing and optimization"],"prefix":"10.1177","volume":"236","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1962-2753","authenticated-orcid":false,"given":"Pedro","family":"Brand\u00e3o","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering of the University of Porto, Porto, Portugal"}]},{"given":"Paulo T","family":"Silva","sequence":"additional","affiliation":[{"name":"Fraunhofer AICOS, Porto, Portugal"}]},{"given":"Marco","family":"Parente","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering of the University of Porto, Porto, Portugal"}]},{"given":"Lu\u00eds","family":"Rosado","sequence":"additional","affiliation":[{"name":"Fraunhofer AICOS, Porto, Portugal"}]}],"member":"179","published-online":{"date-parts":[[2021,12,20]]},"reference":[{"key":"bibr1-14644207211022774","unstructured":"WHO. 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