{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T20:29:38Z","timestamp":1770841778983,"version":"3.50.1"},"reference-count":43,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes &amp; Vascular Disease"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p> To evaluate the effect of rosuvastatin on oxidised low-density lipoprotein\/beta2-glycoprotein I (oxLDL\/\u03b2<jats:sub>2<\/jats:sub>GPI) complex concentration in type 2 diabetes mellitus. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> Open label 2:1 assignment of consecutive diabetic patients into oral rosuvastatin (10 mg daily for six weeks) arm or observational arm with measurements of serum oxLDL\/|\u03b2<jats:sub>2<\/jats:sub>GPI complexes, nitric oxide metabolites, asymmetric dimethyl arginine, nitrotyrosine alongside routine biochemistry at baseline and end of study in all patients. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> After rosuvastatin treatment the mean serum concentration of oxLDL\/\u03b2<jats:sub>2<\/jats:sub>GPI decreased from 0.79\u00b10.49 units\/mL to 0.53\u00b10.36 units\/mL (p&lt;0.001). The decrease was statistically independent from the decrements of mean cholesterol, LDL and triglyceride concentrations (p&lt;0.001) but probably dependent on the decrement of nitrate (p&lt;0.001). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> In type 2 diabetes, treatment with rosuvastatin was associated with a significant reduction of serum concentrations of oxLDL\/\u03b2<jats:sub>2<\/jats:sub>GPI complexes, which is in further support of the already proposed effects of the drug on the oxidative metabolism of lipids and\/or LDL. The oxLDL\/\u03b2<jats:sub>2<\/jats:sub>GPI complex may represent a surrogate marker of oxidative stress in type 2 diabetes. <\/jats:p><\/jats:sec>","DOI":"10.1177\/1474651410388057","type":"journal-article","created":{"date-parts":[[2010,12,21]],"date-time":"2010-12-21T10:51:58Z","timestamp":1292928718000},"page":"292-299","source":"Crossref","is-referenced-by-count":10,"title":["Rosuvastatin Treatment is Associated with a Decrease of Serum Oxidised Low-Density Lipoprotein\/Beta2-Glycoprotein I Complex Concentration in Type 2 Diabetes"],"prefix":"10.1177","volume":"10","author":[{"given":"Paul RJ","family":"Ames","sequence":"first","affiliation":[{"name":"Departments of Haematology and Rheumatology, Airedale General Hospital, Steeton, UK."}]},{"given":"Alfredo","family":"Ortiz-Cadenas","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hospital General de Occidente, Zapopan, Jalisco, Mexico."}]},{"given":"Ignacio Garcia-De La","family":"Torre","sequence":"additional","affiliation":[{"name":"Department of Immunology and Rheumatology, Hospital General de Occidente, Zapopan, Jalisco, Mexico."}]},{"given":"Arnulfo","family":"Nava","sequence":"additional","affiliation":[{"name":"Department of Immunology and Rheumatology, Hospital General de Occidente, Zapopan, Jalisco, Mexico."},{"name":"Clinical Epidemiology Research Unit, UMAE HE CMNO Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico."}]},{"given":"Aldo","family":"Oregon-Miranda","sequence":"additional","affiliation":[{"name":"Department of Immunology and Rheumatology, Hospital General de Occidente, Zapopan, Jalisco, Mexico."}]},{"given":"Joana R","family":"Batuca","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, New University of Lisbon, Lisbon, Portugal."}]},{"given":"Kazuo","family":"Kojima","sequence":"additional","affiliation":[{"name":"Medical and Biological Laboratories Co., Ltd. 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