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To overcome these barriers, it is crucial to implement effective evidence-based therapies in more cost-effective therapeutic formats. The Unified Protocol (UP) was developed for treating comorbid EDs by specifically targeting shared transdiagnostic mechanisms. It can be applied in different therapeutic formats, and combining the group and online formats could enhance the dissemination and accessibility of the UP. This case study describes the application of a 12-week UP intervention via online videoconference to a group of eight adults diagnosed with comorbid anxiety and depressive disorders. The participants were assessed pretreatment, posttreatment, and at a 3-month follow-up. The Reliable Change Index (RCI) was used to assess the clinical significance of treatment outcomes. Five participants completed the intervention and showed a clinically significant decrease in depressive symptom severity, whereas four presented a significant reduction in anxiety symptoms. Significant improvements in emotional regulation and behavioral activation were observed in five participants. Four participants also demonstrated improvements in mindfulness and quality of life. Therapeutic gains were generally maintained or improved at the 3-month follow-up, except in one participant. High levels of participant satisfaction were reported regarding both the intervention program and its delivery format. This case study highlights the acceptability, feasibility and clinical utility of online group UP for treating adults with comorbid EDs, suggesting promising potential for this intervention format.<\/jats:p>","DOI":"10.1177\/15346501251345480","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T12:34:09Z","timestamp":1748522049000},"page":"257-278","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Unified protocol for transdiagnostic treatment of comorbid emotional disorders: An online group case study"],"prefix":"10.1177","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6185-4996","authenticated-orcid":false,"given":"Liliana","family":"Pedro","sequence":"first","affiliation":[{"name":"University of Coimbra, Center for Research in Neuropsychology and Cognitive Behavioral Intervention (CINEICC). 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Faculty of Psychology and Educational Sciences, Coimbra, Portugal"}]},{"given":"Maria Cristina","family":"Canavarro","sequence":"additional","affiliation":[{"name":"University of Coimbra, Center for Research in Neuropsychology and Cognitive Behavioral Intervention (CINEICC). Faculty of Psychology and Educational Sciences, Coimbra, Portugal"}]}],"member":"179","published-online":{"date-parts":[[2025,5,29]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2017.12.004"},{"key":"e_1_3_5_3_1","first-page":"1","article-title":"Systematic review and meta-analysis of the efficacy and effectiveness of the unified protocol for emotional disorders in group format for adults","author":"Ayuso-Bartol A.","year":"2024","unstructured":"Ayuso-Bartol A., G\u00f3mez-Mart\u00ednez M. \u00c1., Riesco-Mat\u00edas P., Yela-Bernab\u00e9 J. R., Crego A., Buz J. (2024). 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