{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T19:12:40Z","timestamp":1788462760029,"version":"build-2803163510"},"reference-count":9,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy Curr"],"abstract":"\n \n \n Monitoring Antiseizure Medication Change Using Ultra Long-Term Electroencephalogram: A Multicenter Study<\/jats:bold>\n <\/jats:p>\n \n Viana PF, McWilliam M, Koren J, Duarte C, Lisy T, Baumgartner C, R\u00f6ssler K, Tomschik M, de Castro AC, Rocamora R, Vilella L, Rubboli G, Weisdorf S, Friedrichs-Maeder C, Kjaer TW, Bhatia S, McAleer D, Hamandi K, Spencer D, Mohanraj R, Richardson MP.\n Ann Neurol<\/jats:italic>\n . 2026 Jul 20. doi: 10.1002\/ana.78305. Epub ahead of print. PMID: 42474097.\n <\/jats:p>\n Objective: Medication dose adjustments are common in treatment-resistant epilepsy, but lack robust evidence, and patient-reported seizure diaries have known limitations. We assessed whether ultra long-term subcutaneous electroencephalogram (sqEEG) improves detection of seizure frequency changes after antiseizure medication adjustments. Methods: A retrospective, multicenter cohort study was carried out across 9 centers in adults with treatment-resistant epilepsy. SqEEG seizure frequency was compared with seizure diaries before and after medication dose increases and reductions, over 7-, 14-, and 30-day windows, using categorical analyses, mixed-effects models and survival analyses. Results: A total of 65 participants (mean age 40.6 years; 59% female) contributed >280,000\u2005h of sqEEG, 9,190 electrographic seizures and 4,850 diary events, including across 160 medication changes. Categorical disagreement between modalities ranged from 36% to 50%, with significant differences at 7 and 14 days for dose reductions, and at 14 days for dose increases. sqEEG recorded 2.2- to 3.4-fold more seizures than diary across all seizure count models (all p\u2009<\u20090.01). Seizure count models showed no statistically significant difference between modalities in detecting treatment-related changes (interaction estimates: 5-38% larger increases with sqEEG for dose reductions, and 13-38% larger reductions with sqEEG for dose increases). SqEEG identified return to baseline seizure counts significantly earlier than diary after dose reductions at 7- and 14-day windows (median 7 vs 13 days and 10 vs 17 days, respectively; adjusted p\u2009=\u20090.046 and 0.042). Interpretation: SqEEG detects more seizures than patient-reported diaries and identifies treatment-related changes earlier, even after modest medication adjustments, particularly after dose reductions, highlighting the potential of objective ultra long-term EEG monitoring in treatment-resistant epilepsy.<\/jats:p>\n <\/jats:boxed-text>\n <\/jats:p>","DOI":"10.1177\/15357597261483433","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T15:07:28Z","timestamp":1788275248000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Is Ultra-Long-Term Subscalp EEG Ready to Go \u201cSolo\u201d? Transforming the Landscape of Antiseizure Medication Management"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9318-3947","authenticated-orcid":false,"given":"Anteneh M.","family":"Feyissa","sequence":"first","affiliation":[{"name":"Department of Neurology, Mayo Clinic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200002033420503"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2021.108383"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70047-3"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/15357597251407934"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/epi.18566"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/epi.18458"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51261"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.78305"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/11795735231209209"}],"container-title":["Epilepsy Currents"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15357597261483433","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15357597261483433","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15357597261483433","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T18:18:06Z","timestamp":1788459486000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15357597261483433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,1]]},"references-count":9,"alternative-id":["10.1177\/15357597261483433"],"URL":"https:\/\/doi.org\/10.1177\/15357597261483433","relation":{},"ISSN":["1535-7597","1535-7511"],"issn-type":[{"value":"1535-7597","type":"print"},{"value":"1535-7511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,1]]},"article-number":"15357597261483433"}}