{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T12:20:35Z","timestamp":1777810835409,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2004,4,1]],"date-time":"2004-04-01T00:00:00Z","timestamp":1080777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:p>Streptococcus sobrinus produces a virulence-associated immunomodulatory protein (VIP) which suppresses the host-specific immune response and induces the early production of IL-10. In this study, we evaluated the effects of therapeutic immunization with this VIP on the incidence of caries in S. sobrinus-infected rats. Groups of Wistar rats were orally infected with S. sobrinus and fed with sucrose-sweetened drinking water ad libitum. Five days later, rats were immunized intranasally with active or heat-inactivated VIP plus alum as adjuvant or PBS plus adjuvant (sham-immunized). After 3 wks, all rats were re-immunized as above. Evaluation of dental caries showed that VIP-immunized animals had significantly fewer enamel sulcal and proximal caries lesions than did the sham-immunized animals (p &lt; 0.001). The protective effects following therapeutic VIP immunization were attributed to the induced salivary immunoglobulin A specific to the VIP. These results offer a promising and safe strategy for the development of a vaccine against dental caries.<\/jats:p>","DOI":"10.1177\/154405910408300416","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:39:42Z","timestamp":1231443582000},"page":"354-358","source":"Crossref","is-referenced-by-count":8,"title":["Therapeutic Vaccine against\n                    <i>Streptococcus sobrinus<\/i>\n                    -induced Caries"],"prefix":"10.1177","volume":"83","author":[{"given":"M.","family":"Dinis","sequence":"first","affiliation":[{"name":"Laboratory of Immunology, ICBAS-Instituto de Ci\u00eancias Biom\u00e9dicas de Abel Salazar, Lg. Prof. Abel Salazar 2, 4099-003 Porto,"},{"name":"Instituto de Biologia Molecular e Celular, Porto,"},{"name":"Faculdade de Medicina de Coimbra-Hospitais da Universidade de Coimbra, and"},{"name":"Faculdade de Medicina de Coimbra -Instituto de Patologia Experimental-, Coimbra, Portugal;"},{"name":"authors contributing equally to this work;"}]},{"given":"D.","family":"Tavares","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, ICBAS-Instituto de Ci\u00eancias Biom\u00e9dicas de Abel Salazar, Lg. Prof. Abel Salazar 2, 4099-003 Porto,"},{"name":"Instituto de Biologia Molecular e Celular, Porto,"},{"name":"Faculdade de Medicina de Coimbra-Hospitais da Universidade de Coimbra, and"},{"name":"Faculdade de Medicina de Coimbra -Instituto de Patologia Experimental-, Coimbra, Portugal;"},{"name":"authors contributing equally to this work;"}]},{"given":"A.J.M.M.","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, ICBAS-Instituto de Ci\u00eancias Biom\u00e9dicas de Abel Salazar, Lg. Prof. Abel Salazar 2, 4099-003 Porto,"},{"name":"Instituto de Biologia Molecular e Celular, Porto,"},{"name":"Faculdade de Medicina de Coimbra-Hospitais da Universidade de Coimbra, and"},{"name":"Faculdade de Medicina de Coimbra -Instituto de Patologia Experimental-, Coimbra, Portugal;"},{"name":"authors contributing equally to this work;"}]},{"given":"R.","family":"Faria","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, ICBAS-Instituto de Ci\u00eancias Biom\u00e9dicas de Abel Salazar, Lg. Prof. Abel Salazar 2, 4099-003 Porto,"},{"name":"Instituto de Biologia Molecular e Celular, Porto,"},{"name":"Faculdade de Medicina de Coimbra-Hospitais da Universidade de Coimbra, and"},{"name":"Faculdade de Medicina de Coimbra -Instituto de Patologia Experimental-, Coimbra, Portugal;"},{"name":"authors contributing equally to this work;"}]},{"given":"A.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, ICBAS-Instituto de Ci\u00eancias Biom\u00e9dicas de Abel Salazar, Lg. 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