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Researchers are taking more advantage of this medium as comics in research has become a growing field. Notwithstanding, comics as research practice\/method has received less attention, particularly the research framework involved in making comics. Here, we detail the research process through the drawing to create a comic about non-alcoholic fatty liver disease. We argue that deciding on visual choices intersecting the perspectives of both artist and researchers whilst promoting reflexivity can be best understood through mutual collaboration. We depict examples of how the active inter\/trans\/disciplinary research environment, incorporating perceptions, experiences, tensions, from the artist and researchers, and respective disciplines, also informed by patient testimonies, resulted in (new) meanings and ways of thinking in terms of visual content and structure. Particularly when creating the characters and when using multimodality and resources afforded by comics \u2013visual metaphor, anthropomorphism, and scientific sketchnote\u2013, to portray the human body and bring familiarity and simplicity to complex cellular and metabolic events. We end with a comic strip framing comics as research practice, outlining the active engagement during the drawing processes and the research framework that combined a mixed method research approach for creating a tool useful towards understanding science and health promotion. <\/jats:p>","DOI":"10.1177\/16094069231183118","type":"journal-article","created":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T08:33:42Z","timestamp":1696581222000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Comics in Science and Health Communication: Insights From Mutual Collaboration and Framing a Research Practice"],"prefix":"10.1177","volume":"22","author":[{"given":"Rui","family":"Tavares","sequence":"first","affiliation":[{"name":"CNC-Center for Neuroscience and Cell Biology, CIBB, University of Coimbra, Coimbra, Portugal"},{"name":"PhD Programme in Experimental Biology and Biomedicine (PDBEB), IIIUC-Institute for Interdisciplinary Research, University of Coimbra, Coimbra, Portugal"},{"name":"CES-Centre for Social Studies, University of Coimbra, Coimbra, Portugal"}]},{"given":"Mireia","family":"Alemany-Pag\u00e8s","sequence":"additional","affiliation":[{"name":"CNC-Center for Neuroscience and Cell Biology, CIBB, University of Coimbra, Coimbra, Portugal"},{"name":"PhD Programme in Experimental Biology and Biomedicine (PDBEB), IIIUC-Institute for Interdisciplinary Research, University of Coimbra, Coimbra, Portugal"}]},{"given":"Sara","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"CES-Centre for Social Studies, University of Coimbra, Coimbra, Portugal"}]},{"given":"Neil","family":"Cohn","sequence":"additional","affiliation":[{"name":"Department of Communication and Cognition, Tilburg University, The Netherlands"}]},{"given":"Jo\u00e3o","family":"Ramalho-Santos","sequence":"additional","affiliation":[{"name":"CNC-Center for Neuroscience and Cell Biology, CIBB, University of Coimbra, Coimbra, Portugal"},{"name":"DCV-Department of Life Sciences, University of Coimbra, Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3295-1284","authenticated-orcid":false,"given":"Anabela Marisa","family":"Azul","sequence":"additional","affiliation":[{"name":"CNC-Center for Neuroscience and Cell Biology, CIBB, University of Coimbra, Coimbra, Portugal"},{"name":"IIIUC-Institute for Interdisciplinary Research, University of Coimbra, Coimbra, Portugal"}]}],"member":"179","published-online":{"date-parts":[[2023,10,6]]},"reference":[{"key":"bibr1-16094069231183118","doi-asserted-by":"publisher","DOI":"10.1111\/eci.13642"},{"key":"bibr2-16094069231183118","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-020-09249-5"},{"key":"bibr3-16094069231183118","doi-asserted-by":"publisher","DOI":"10.14195\/978-989-26-2040-4"},{"key":"bibr4-16094069231183118","doi-asserted-by":"publisher","DOI":"10.1093\/heapro\/daac165"},{"key":"bibr5-16094069231183118","doi-asserted-by":"publisher","DOI":"10.1080\/10410236.2023.2215908"},{"key":"bibr6-16094069231183118","doi-asserted-by":"publisher","DOI":"10.1007\/s10912-013-9205-0"},{"key":"bibr7-16094069231183118","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1765"},{"key":"bibr8-16094069231183118","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0140908"},{"issue":"1","key":"bibr9-16094069231183118","first-page":"134","volume":"20","author":"Ashwal 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