{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T19:57:56Z","timestamp":1775159876687,"version":"3.50.1"},"reference-count":15,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2018,5,17]],"date-time":"2018-05-17T00:00:00Z","timestamp":1526515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Centro Hospitalar Lisboa Norte","award":["Bolsa de Investiga\u00e7\u00e3o"],"award-info":[{"award-number":["Bolsa de Investiga\u00e7\u00e3o"]}]},{"name":"Funda\u00e7\u00e3o Astrazeneca-Faculty of Medicine of the University of Lisbon","award":["Bolsa de Investiga\u00e7\u00e3o"],"award-info":[{"award-number":["Bolsa de Investiga\u00e7\u00e3o"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Stroke"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec><jats:title>Rationale<\/jats:title><jats:p> After a cerebral vein thrombosis, there is an increased risk of further venous thromboembolic events. The optimal duration of anticoagulation after cerebral vein thrombosis is unknown. <\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p> To compare efficacy and safety of a policy of short- (3\u20136 months) versus long-term (12 months) anticoagulation (any type venous thromboembolic events) after cerebral vein thrombosis for the prevention of venous thromboembolic events. <\/jats:p><\/jats:sec><jats:sec><jats:title>Sample size estimates<\/jats:title><jats:p> A sample of 1428 patients (749 per arm) allows detecting a reduction from 10 to 5% in the risk of venous thromboembolic event recurrence with 80% power at 5% significance, with 3% dropout rate. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and design<\/jats:title><jats:p> An international multicenter, prospective cluster-randomized trial with equal allocation between both interventions (ISRCTN25644448). Each cluster is a participating center, which accepted to be randomly allocated to one of the anticoagulation policies. Eligible patients are adults with radiologically confirmed cerebral vein thrombosis within 30 days, and stable to initiate post-acute anticoagulation. Patients judged by the investigator to be an absolute indication for permanent anticoagulation are excluded. Follow-up is at 6, 12 and 24 months. <\/jats:p><\/jats:sec><jats:sec><jats:title>Study outcomes<\/jats:title><jats:p> Primary efficacy outcome is any symptomatic and confirmed fatal\/nonfatal venous thromboembolic event (recurrent-cerebral vein thrombosis or non-cerebral venous thromboembolic event). Primary safety outcomes include bleeding events during treatment periods and death from any cause. <\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p> This study responds to a knowledge gap in the post-acute management of cerebral vein thrombosis patients by comparing short- versus long-term anticoagulation for the prevention of venous thromboembolic event recurrence. <\/jats:p><\/jats:sec>","DOI":"10.1177\/1747493018778137","type":"journal-article","created":{"date-parts":[[2018,5,17]],"date-time":"2018-05-17T13:33:36Z","timestamp":1526564016000},"page":"771-774","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":37,"title":["The benefit of EXtending oral antiCOAgulation treatment (EXCOA) after acute cerebral vein thrombosis (CVT): EXCOA-CVT cluster randomized trial protocol"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4660-6051","authenticated-orcid":false,"given":"Bruno","family":"Miranda","sequence":"first","affiliation":[{"name":"Department of Neurosciences and Mental Health, Neurology, Hospital de Santa Maria-CHLN, Lisbon, Portugal"},{"name":"Instituto de Medicina Molecular, Faculty of Medicine \u2013 University of Lisbon, Lisbon, Portugal"}]},{"given":"Sanjith","family":"Aaron","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences, Christian Medical College and Hospital, Vellore, India"}]},{"given":"Antonio","family":"Arauz","sequence":"additional","affiliation":[{"name":"Department of Neurology, Instituto Nacional de Neurologia y Neurocirurgia Manuel Velasco Su\u00e1rez, Mexico City, Mexico"}]},{"given":"Fernando","family":"Barinagarrementeria","sequence":"additional","affiliation":[{"name":"Hospital H+, Department of Neurology, Quer\u00e9taro, M\u00e9xico"}]},{"given":"Afshin","family":"Borhani-Haghighi","sequence":"additional","affiliation":[{"name":"Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran"}]},{"given":"Marta","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Neurology Department, Hospital de S\u00e3o Jo\u00e3o \u2013 Centro Hospitalar S\u00e3o Jo\u00e3o, Porto, Portugal"},{"name":"Department of Clinical Neurosciences and Mental Health, Faculty of Medicine \u2013 University of Porto, Porto, Portugal"}]},{"given":"Adriana B","family":"Conforto","sequence":"additional","affiliation":[{"name":"Neurology Clinical Division, Hospital das Cl\u00ednicas \u2013 S\u00e3o Paulo University, S\u00e3o Paulo, Brazil"},{"name":"Department of Neurology, Hospital Israelita Albert Einstein, S\u00e3o Paulo, Brazil"}]},{"given":"Jonathan M","family":"Coutinho","sequence":"additional","affiliation":[{"name":"Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands"}]},{"given":"Jan","family":"Stam","sequence":"additional","affiliation":[{"name":"Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands"}]},{"given":"Patr\u00edcia","family":"Canh\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Neurosciences and Mental Health, Neurology, Hospital de Santa Maria-CHLN, Lisbon, Portugal"},{"name":"Instituto de Medicina Molecular, Faculty of Medicine \u2013 University of Lisbon, Lisbon, Portugal"}]},{"given":"Jos\u00e9 M","family":"Ferro","sequence":"additional","affiliation":[{"name":"Department of Neurosciences and Mental Health, Neurology, Hospital de Santa Maria-CHLN, Lisbon, Portugal"},{"name":"Instituto de Medicina Molecular, Faculty of Medicine \u2013 University of Lisbon, Lisbon, 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