{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T19:28:39Z","timestamp":1768591719304,"version":"3.49.0"},"reference-count":18,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2025,5,24]],"date-time":"2025-05-24T00:00:00Z","timestamp":1748044800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,24]],"date-time":"2025-05-24T00:00:00Z","timestamp":1748044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Stroke"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Anticoagulation is the mainstay acute therapy for cerebral venous thrombosis (CVT). Decompressive surgery is required in a small minority of patients with large parenchymal lesions and impending herniation, which requires a temporary suspension of anticoagulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>The objective of this study was to identify the optimal timing for starting or resuming anticoagulation following decompressive surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Data were collected from the Decompressive Surgery for CVT Study 2 (DECOMPRESS2), a prospective multinational cohort observational study of 118 patients with severe CVT treated by decompressive surgery. We assessed the frequency of new hemorrhagic and venous thrombotic events from admission to discharge in patients who started or resumed anticoagulation &lt;24\u2009h (early) and \u2a7e24 (late) following surgery, using propensity score matching and logistic regression. Death and disability were evaluated by the modified Rankin scale (mRS\u2009&gt;\u20092) at discharge and at 1 year follow-up and compared between the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Of the 90 patients available for analysis, 35 (39%) started or resumed anticoagulation within the first 24 h after surgery while 55 (61%) did so later than 24 h. Overall frequency of patients with new hemorrhagic or venous thrombotic events from admission to discharge was 26.7% (24 patients), without crude or adjusted for the propensity score statistically significant difference between the early and late anticoagulation groups (&lt;24\u2009h, 11 patients, 31%, vs \u2a7e24\u2009h, 13 patients, 24%; odds ratio (OR): 0.86; 95% confidence interval (CI): 0.24 to 3.04; \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.33, p\u2009=\u20090.57). The distribution of major hemorrhagic events was also comparable: 8 (23%) bleedings in the &lt;24 h, and 9 (16%) in the \u2a7e24 h (\u03c7\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.24, p\u2009=\u20090.62). No CVT recurred. Two venous thrombotic events occurred in &lt;24\u2009h (6%) and 5 in the \u2a7e24\u2009h (9%) group. There was no association between anticoagulation timing and death or dependence (mRS 3-6) at discharge (OR: 1.65. 95% CI: 0.30 to 9.01, p\u2009=\u20090.56), or at 1 year follow-up (OR: 2.19, 95% CI: 0.78 to 6.10, p\u2009=\u20090.14).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The results of this cohort study suggest that the timing of anticoagulation therapy following decompressive surgery for CVT does not significantly influence the risk of new bleeding or venous thrombotic events or disability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17474930251341725","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T20:16:50Z","timestamp":1746044210000},"page":"1225-1234","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Timing of starting anticoagulation following decompressive surgery for cerebral vein and sinus thrombosis: An observational study"],"prefix":"10.1177","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7965-8846","authenticated-orcid":false,"given":"Mariana C","family":"Taveira","sequence":"first","affiliation":[{"name":"Centro de Estudos Egas Moniz, Faculdade de Medicina, Universidade de Lisboa, Portugal"},{"name":"Servi\u00e7o de Neurologia, Departamento de Neuroci\u00eancias e Sa\u00fade Mental, Unidade Local de Sa\u00fade Santa Maria, Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5151-1500","authenticated-orcid":false,"given":"Sanjith","family":"Aaron","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Neurological Sciences, Christian Medical College and Hospital, Vellore, Tamil Nadu, India"}]},{"given":"Jorge M","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Neurologia, Unidade Local de Sa\u00fade S\u00e3o Jos\u00e9, Lisboa, Portugal"}]},{"given":"Jonathan M","family":"Coutinho","sequence":"additional","affiliation":[{"name":"Department of Neurology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands"}]},{"given":"Patr\u00edcia","family":"Canh\u00e3o","sequence":"additional","affiliation":[{"name":"Centro de Estudos Egas Moniz, Faculdade de Medicina, Universidade de Lisboa, Portugal"},{"name":"Servi\u00e7o de Neurologia, Departamento de Neuroci\u00eancias e Sa\u00fade Mental, Unidade Local de Sa\u00fade Santa Maria, Lisboa, Portugal"}]},{"given":"Adriana","family":"Conforto","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}]},{"given":"Antonio","family":"Arauz","sequence":"additional","affiliation":[{"name":"Stroke Clinic, Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda Manuel Velasco Su\u00e1rez, Mexico City, Mexico"}]},{"given":"Marta","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Neurologia, Unidade Local de Sa\u00fade S\u00e3o Jo\u00e3o, Porto, Portugal"},{"name":"Departamento de Neuroci\u00eancias Cl\u00ednicas e Sa\u00fade Mental, Faculdade de Medicina da Universidade do Porto, Porto, Portugal"}]},{"given":"Jaime","family":"Masjuan","sequence":"additional","affiliation":[{"name":"Servicio de Neurolog\u00eda, Hospital Universitario Ram\u00f3n y Cajal, IRYCIS, Madrid, Spain"},{"name":"Departamento de Medicina, Universidad de Alcal\u00e1. Red RICORS, Madrid, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8976-5696","authenticated-orcid":false,"given":"Vijay K","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore"}]},{"given":"Jukka","family":"Putaala","sequence":"additional","affiliation":[{"name":"Department of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland"}]},{"given":"Maarten","family":"Uyttenboogaart","sequence":"additional","affiliation":[{"name":"Department of Neurology and Medical Imaging Center, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2074-1861","authenticated-orcid":false,"given":"David J","family":"Werring","sequence":"additional","affiliation":[{"name":"Stroke Research Centre, UCL Queen Square Institute of Neurology, London, UK"}]},{"given":"Rodrigo","family":"Bazan","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina, Universidade Estadual Paulista Julio de Mesquita Filho (Unesp), Botucatu, S\u00e3o Paulo, Brazil"}]},{"given":"Sandeep","family":"Mohindra","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Post Graduate Institute of Medical Education &amp; Research (PGIMER), Chandigarh, India"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5891-4688","authenticated-orcid":false,"given":"Jochen","family":"Weber","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Steinenberg Clinic, Reutlingen, Germany"}]},{"given":"Bert A","family":"Coert","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands"}]},{"given":"Prabhu","family":"Kirubakaran","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Neurological Sciences, Christian Medical College and Hospital, Vellore, Tamil Nadu, India"}]},{"given":"Mayte","family":"Sanchez van Kammen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands"}]},{"given":"Pankaj","family":"Singh","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Neurological Sciences, Christian Medical College and Hospital, Vellore, Tamil Nadu, India"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6702-7924","authenticated-orcid":false,"given":"Diana","family":"Aguiar de Sousa","sequence":"additional","affiliation":[{"name":"Centro de Estudos Egas Moniz, Faculdade de Medicina, Universidade de Lisboa, Portugal"},{"name":"Neurosciences Department, Stroke Center, Centro Hospitalar Universit\u00e1rio Lisboa Central -ULS S\u00e3o Jos\u00e9, Lisbon, Portugal"},{"name":"Gulbenkian Institute for Molecular Medicine, Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2343-9097","authenticated-orcid":false,"given":"Jos\u00e9 M","family":"Ferro","sequence":"additional","affiliation":[{"name":"Centro de Estudos Egas Moniz, Faculdade de Medicina, Universidade de Lisboa, Portugal"}]}],"member":"179","published-online":{"date-parts":[[2025,5,24]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2017.104"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000117571.76197.26"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000173152.84438.1c"},{"key":"e_1_3_2_5_2","first-page":"195","article-title":"European Stroke Organization guideline for the diagnosis and treatment of cerebral venous thrombosis\u2014endorsed by the European Academy of Neurology","volume":"2","author":"Ferro JM","year":"2017","unstructured":"Ferro JM, Bousser MG, Canhao P, et al. 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