{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:10:04Z","timestamp":1777943404736,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Health Research Board Ireland"},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["German Research Foundation 397530000"],"award-info":[{"award-number":["German Research Foundation 397530000"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Stroke"],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The Colchicine for prevention of vascular inflammation in Non-CardioEmbolic stroke (CONVINCE) trial evaluated long-term treatment with colchicine for the prevention of major adverse cardiovascular events (MACE) in a stroke population. Although the intention-to-treat analysis did not demonstrate a significant reduction in the primary endpoint, fewer outcome events were observed in the colchicine-treated group. It is unknown if a potential treatment effect is modified by ischemic stroke etiology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>In this pre-specified secondary analysis, we aimed to evaluate the efficacy of colchicine for prevention of MACE in patients with minor stroke or high-risk transient ischemic attack (TIA) according to index event stroke etiology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 3154 patients with recent non-cardioembolic stroke or TIA were randomly assigned to receive colchicine, 0.5\u2009mg daily in addition to guideline-based usual care or usual care alone. The primary endpoint was a composite of first fatal or non-fatal recurrent ischemic stroke, myocardial infarction, cardiac arrest, or hospitalization for unstable angina. Subgroups of patients with large-artery atherosclerosis, small-vessel disease, and cryptogenic stroke were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 3100 patients were included in the current analysis. The treatment effect did not vary across stroke subtype subgroups (p\u2009=\u20090.64 for interaction). In patients allocated to colchicine versus usual care alone, the primary endpoint occurred in 32 of 260 (12.3%) versus 42 of 263 (16%) patients with large-artery atherosclerosis (hazard ratio (HR), 0.77 (95% CI, 0.48\u20131.22)); 39 of 419 (9.3%) versus 47 of 435 (10.8%) patients with small-vessel occlusion (HR, 0.87 (95% CI, 0.57\u20131.34)); and 82 of 877 (9.4%) versus 92 of 846 (10.5%) patients with cryptogenic stroke (HR, 0.89 (95% CI, 0.66\u20131.12)).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The direction of effect for prevention of recurrent MACE favored colchicine, consistent with randomized trials in coronary disease, regardless of stroke subtype. Future stroke trials should consider selecting patients with evidence of atherosclerosis irrespective of stroke subtype.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration:<\/jats:title>\n                    <jats:p>ClinicalTrials.gov Identifier: NCT02898610<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17474930251406818","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T12:32:56Z","timestamp":1764678776000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of colchicine for secondary prevention according to stroke subtype: A secondary analysis of the CONVINCE randomized trial"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4240-7645","authenticated-orcid":false,"given":"Louise","family":"Maes","sequence":"first","affiliation":[{"name":"Department of Neurology, University Hospitals Leuven, Leuven, Belgium"},{"name":"Department of Neurosciences, Experimental Neurology, KU Leuven\u2014University of Leuven, Leuven, Belgium"}]},{"given":"Cathal","family":"Walsh","sequence":"additional","affiliation":[{"name":"TCD Biostatistics Unit, Discipline of Public Health and Primary Care, School of Medicine, Trinity College Dublin, Dublin, Ireland"}]},{"given":"Christian","family":"Weimar","sequence":"additional","affiliation":[{"name":"Institute for Medical Informatics, Biometry, and Epidemiology, University Hospital, University Duisburg\u2013Essen and Germany and BDH Clinic Elzach, Elzach, Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1808-5968","authenticated-orcid":false,"given":"Francisco","family":"Purroy","sequence":"additional","affiliation":[{"name":"Stroke Unit, Department of Neurology, Hospital Universitari Arnau de Vilanova de Lleida, Lleida, Spain"},{"name":"Biomedical Research Institute of Lleida, Universitat de Lleida, Lleida, Spain"}]},{"given":"Christopher","family":"Price","sequence":"additional","affiliation":[{"name":"Population Health Sciences Institute, Newcastle University, Newcastle, UK"}]},{"given":"Brian","family":"Clarke","sequence":"additional","affiliation":[{"name":"St George\u2019s University Hospitals, London, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1401-2398","authenticated-orcid":false,"given":"Pedro","family":"Castro","sequence":"additional","affiliation":[{"name":"Department of Neurology, Centro Hospitalar Universit\u00e1rio S\u00e3o Jo\u00e3o, Cardiovascular R&amp;D Unit, Faculty of Medicine, University of Porto, Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1956-1866","authenticated-orcid":false,"given":"Anna","family":"Czlonkowska","sequence":"additional","affiliation":[{"name":"Second Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9147-875X","authenticated-orcid":false,"given":"Elisa","family":"Cuadrado-Godia","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital del Mar Research Institute, Faculty of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0521-4051","authenticated-orcid":false,"given":"Urs","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Bern and University of Bern, Bern, Switzerland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6913-5526","authenticated-orcid":false,"given":"Ana Catarina","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Hospital Santa Maria-CHLN, Centro de Estudos Egas Moniz, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6269-1543","authenticated-orcid":false,"given":"Michael D","family":"Hill","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences &amp; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary and Foothills Medical Centre, Calgary, AB, Canada"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6159-4795","authenticated-orcid":false,"given":"Dalius","family":"Jatuzis","sequence":"additional","affiliation":[{"name":"Centre of Neurology, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6074-0727","authenticated-orcid":false,"given":"Janika","family":"K\u00f5rv","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, Institute of Clinical Medicine, University of Tartu, Estonia"}]},{"given":"Christina","family":"Kruuse","sequence":"additional","affiliation":[{"name":"Department of Neurology, Herlev and Gentofte Hospital, and Department of Brain and Spinal Cord Injury, Rigshospitalet 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