{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T14:17:53Z","timestamp":1777731473142,"version":"3.51.4"},"reference-count":85,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2015,9,21]],"date-time":"2015-09-21T00:00:00Z","timestamp":1442793600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Innate Immun"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:p>ILs, as essential innate immune modulators, are involved in an array of biological processes. In the European rabbit ( Oryctolagus cuniculus) IL-1\u03b1, IL-1\u03b2, IL-2, IL-4, IL-8, IL-10, IL-12A, IL-12B, IL-15 and IL-18 have been implicated in inflammatory processes and in the immune response against rabbit hemorrhagic disease virus and myxoma virus infections. In this study we characterized these ILs in six Lagomorpha species (European rabbit, pygmy rabbit, two cottontail rabbit species, European brown hare and American pika). Overall, these ILs are conserved between lagomorphs, including in their exon\/intron structure. Most differences were observed between leporids and American pika. Indeed, when comparing both, some relevant differences were observed in American pika, such as the location of the stop codon in IL-1\u03b1 and IL-2, the existence of a different transcript in IL8 and the number of cysteine residues in IL-1\u03b2. Changes at N-glycosylation motifs were also detected in IL-1, IL-10, IL-12B and IL-15. IL-1\u03b1 is the protein that presents the highest evolutionary distances, which is in contrast to IL-12A where the distances between lagomorphs are the lowest. For all these ILs, sequences of human and European rabbit are more closely related than between human and mouse or European rabbit and mouse.<\/jats:p>","DOI":"10.1177\/1753425915606209","type":"journal-article","created":{"date-parts":[[2015,9,22]],"date-time":"2015-09-22T20:09:06Z","timestamp":1442952546000},"page":"787-801","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":29,"title":["Genetic characterization of interleukins (IL-1\u03b1, IL-1\u03b2, IL-2, IL-4, IL-8, IL-10, IL-12A, IL-12B, IL-15 and IL-18) with relevant biological roles in lagomorphs"],"prefix":"10.1177","volume":"21","author":[{"given":"Fabiana","family":"Neves","sequence":"first","affiliation":[{"name":"CIBIO, InBIO\u2014Research Network in Biodiversity and Evolutionary Biology, Universidade do Porto, Campus de Vair\u00e3o, Vair\u00e3o, Portugal"},{"name":"UMIB\/UP\u2014Unidade Multidisciplinar de Investiga\u00e7\u00e3o Biom\u00e9dica\/Universidade do Porto, Porto, Portugal"}]},{"given":"Joana","family":"Abrantes","sequence":"additional","affiliation":[{"name":"CIBIO, InBIO\u2014Research Network in Biodiversity and Evolutionary Biology, Universidade do Porto, Campus de Vair\u00e3o, Vair\u00e3o, Portugal"}]},{"given":"Tereza","family":"Almeida","sequence":"additional","affiliation":[{"name":"CIBIO, InBIO\u2014Research Network in Biodiversity and Evolutionary Biology, Universidade do Porto, Campus de Vair\u00e3o, Vair\u00e3o, Portugal"}]},{"given":"Ana Lemos","family":"de Matos","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, FL, USA"}]},{"given":"Paulo P","family":"Costa","sequence":"additional","affiliation":[{"name":"UMIB\/UP\u2014Unidade Multidisciplinar de Investiga\u00e7\u00e3o Biom\u00e9dica\/Universidade do Porto, Porto, Portugal"},{"name":"Departmento Gen\u00e9tica, CSPGF, Instituto Nacional de Sa\u00fade Dr. Ricardo Jorge, Porto, Portugal"}]},{"given":"Pedro J","family":"Esteves","sequence":"additional","affiliation":[{"name":"CIBIO, InBIO\u2014Research Network in Biodiversity and Evolutionary Biology, Universidade do Porto, Campus de Vair\u00e3o, Vair\u00e3o, Portugal"},{"name":"Departamento de Biologia, Faculdade de Ci\u00eancias da Universidade do Porto, Porto, Portugal"},{"name":"CITS\u2014Centro de Investiga\u00e7\u00e3o em Tecnologias de Sa\u00fade, CESPU, Gandra, Portugal"}]}],"member":"179","published-online":{"date-parts":[[2015,9,21]]},"reference":[{"key":"bibr1-1753425915606209","first-page":"37","volume":"2","author":"Afzal N","year":"2012","journal-title":"Biol Biomed Rep"},{"key":"bibr2-1753425915606209","doi-asserted-by":"publisher","DOI":"10.1042\/bj20030407"},{"key":"bibr3-1753425915606209","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4889(02)00321-X"},{"key":"bibr4-1753425915606209","doi-asserted-by":"publisher","DOI":"10.1186\/1479-7364-5-1-30"},{"key":"bibr5-1753425915606209","doi-asserted-by":"publisher","DOI":"10.1016\/j.dci.2003.09.004"},{"key":"bibr6-1753425915606209","doi-asserted-by":"publisher","DOI":"10.1007\/s00239-004-0313-3"},{"key":"bibr7-1753425915606209","doi-asserted-by":"publisher","DOI":"10.1007\/s002390010085"},{"key":"bibr8-1753425915606209","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.molbev.a026425"},{"key":"bibr9-1753425915606209","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-2291"},{"key":"bibr10-1753425915606209","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-013-2860-7"},{"key":"bibr11-1753425915606209","doi-asserted-by":"publisher","DOI":"10.1016\/S1297-319X(01)00310-4"},{"key":"bibr12-1753425915606209","doi-asserted-by":"publisher","DOI":"10.1177\/1753425913486687"},{"key":"bibr13-1753425915606209","doi-asserted-by":"publisher","DOI":"10.1080\/10635150490445715"},{"key":"bibr14-1753425915606209","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059668"},{"key":"bibr15-1753425915606209","doi-asserted-by":"crossref","unstructured":"Chapman JA and John EC Flux. 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Gene trees, species trees, and species networks. In: Guerra R and Goldstein D (eds)\n                      Meta-analysis and Combining Information in Genetics and Genomics\n                      . 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