{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:55:13Z","timestamp":1767707713150,"version":"3.38.0"},"reference-count":29,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therap Adv Gastroenterol"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> Therapeutic drug monitoring (TDM)-based algorithms can be used to guide infliximab (IFX) adjustments in inflammatory bowel disease (IBD) patients. This study aimed to explore a rapid IFX-quantification test from a clinical perspective. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> This manuscript describes a prospective cohort study involving 110 ulcerative colitis (UC) patients on the maintenance phase of IFX. IFX trough levels were quantified using a rapid quantification assay and a commonly-used reference kit. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> Irrespective of the assay used to measure IFX, its through levels were statistically different between patients with and without endoscopic remission (Mayo endoscopic score = 0), as well as between patients stratified by their faecal calprotectin (FC) levels. Despite the fact that the two methods correlated well with each other [Spearman\u2019s rank correlation coefficient = 0.843, p &lt; 0.001; intraclass correlation coefficients = 0.857, 95% confidence interval (CI): 0.791\u20130.903], there was a discernible systematic variation; values obtained with the reference kit were on average 2.62 units higher than those obtained with the rapid assay. Notwithstanding, 3 \u00b5g\/ml was shown to be an acceptable cut-off to assess endoscopic status and inflammatory burden levels using both assays. The percentage of patients that had a positive outcome when the IFX concentration measured by the rapid assay ranked above 3 \u00b5g\/ml was 88% both for a Mayo endoscopic score \u2a7d 1 and for an FC concentration &lt;250 \u00b5g\/g. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p> Based on this study, we concluded that using the rapid IFX assessment system with a 3 \u00b5g\/ml threshold is a reliable alternative to the time-consuming enzyme-linked immunosorbent assays in patients on the maintenance phase of IFX. <\/jats:p><\/jats:sec>","DOI":"10.1177\/1756283x17722916","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T11:47:10Z","timestamp":1502452030000},"page":"651-660","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Clinical performance of an infliximab rapid quantification assay"],"prefix":"10.1177","volume":"10","author":[{"given":"Fernando","family":"Magro","sequence":"first","affiliation":[{"name":"Department of Biomedicine, Unity of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, Porto, Portugal"}]},{"given":"Joana","family":"Afonso","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Unity of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, Porto, Portugal MedInUP, Centre for Drug Discovery and Innovative Medicines, University of Porto, Porto, Portugal"}]},{"given":"Susana","family":"Lopes","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Centro Hospitalar S\u00e3o Jo\u00e3o, Porto, Portugal"}]},{"given":"Rosa","family":"Coelho","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Centro Hospitalar S\u00e3o Jo\u00e3o, Porto, Portugal"}]},{"given":"Raquel","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Hospital de Braga, Braga, Portugal"}]},{"given":"Paulo","family":"Caldeira","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Centro Hospitalar do Algarve, Faro, Portugal"}]},{"given":"Paula","family":"Lago","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Centro Hospitalar do Porto, Porto, Portugal"}]},{"given":"Helena Tavares","family":"de Sousa","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Centro Hospitalar do Algarve, Portim\u00e3o, Portugal Department of Medical Biosciences and Medicine, University of Algarve, Faro, Portugal"},{"name":"Algarve Biomedical Centre (ABC), University of Algarve, Portugal"}]},{"given":"Jaime","family":"Ramos","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Centro Hospitalar de Lisboa, Lisboa, Portugal"}]},{"given":"Ana Rita","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Centro Hospitalar Lisboa Norte, Lisboa, Portugal"}]},{"given":"Paula","family":"Ministro","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Hospital de S. Teot\u00f3nio, Viseu, Portugal"}]},{"given":"Isadora","family":"Rosa","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Instituto Portugu\u00eas de Oncologia de Lisboa, Lisboa, Portugal"}]},{"given":"T\u00e2nia","family":"Meira","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Hospital Garcia de Orta, Almada, Portugal"}]},{"given":"Patr\u00edcia","family":"Andrade","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Centro Hospitalar S\u00e3o Jo\u00e3o, Porto, Portugal"}]},{"given":"Jo\u00e3o-Bruno","family":"Soares","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Hospital de Braga, Braga, Portugal"}]},{"given":"Diana","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Centro Hospitalar de Lisboa, Lisboa, Portugal"}]},{"given":"Paula","family":"Sousa","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Hospital de S. 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