{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T12:16:25Z","timestamp":1764936985767,"version":"3.41.2"},"reference-count":34,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"GEDII - Grupo de Estudos de Doen\u00e7a Inflamat\u00f3ria Intestinal"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therap Adv Gastroenterol"],"published-print":{"date-parts":[[2018,1,1]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> The treatment goal of Crohn\u2019s disease (CD) has moved towards achieving mucosal healing, resolution of transmural inflammation, and normalization of biomarkers. The purpose of this study was to evaluate how well computed tomography enterography (CTE) and fecal calprotectin (FC) correlated with endoscopic activity in newly diagnosed patients with CD and after 1 year of therapy. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> Consecutive patients with newly diagnosed CD were evaluated by endoscopy, CTE, and FC at diagnosis and 12 months after beginning immunosuppression. Endoscopic severity was assessed using the Simplified Endoscopic Score for Crohn\u2019s Disease (SES-CD). Biomarkers, clinical indexes, and FC were recorded on the day of ileocolonoscopy at diagnosis and 1 year after diagnosis. We adapted a CTE score for disease activity based on radiological signs of inflammation (i.e. mural thickness, mural hyperenhancement, mesenteric fat proliferation, mesenteric fat densification, comb sign, presence of strictures, fistulas, abscesses, ascites, and lymphadenopathy). Correlations between endoscopy, CTE, and FC were assessed using Spearman\u2019s rank correlation. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> A total of 29 patients (48% women; median age 30 (24.5\u201335.5) years) were included in this prospective cohort. CTE findings significantly correlated with endoscopic findings. Endoscopic remission (ER) at 1-year follow up significantly correlated with improvement in mural hyperenhancement ( p = 0.004), mesenteric fat densification ( p = 0.001), comb sign ( p = 0.004), and strictures ( p = 0.008) in CTE. None of the CTE findings improved in patients without ER. FC correlated with SES-CD ( rs = 0.696, p &lt; 0.001) and with CTE features of inflammation ( rs = 0.596, p &lt; 0.001). A cut-off of 100 \u00b5g\/g predicted ER with 92% sensitivity, 65% specificity, and 83% accuracy (area under curve 0.878, p &lt; 0.001). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p> CTE findings and FC levels correlated with endoscopic activity in CD both at diagnosis and at 1-year follow up. These two noninvasive markers of disease activity may be used as an alternative to endoscopy to monitor disease response to therapy. <\/jats:p><\/jats:sec>","DOI":"10.1177\/1756284818769075","type":"journal-article","created":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T10:22:51Z","timestamp":1524133371000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":28,"title":["Monitoring Crohn\u2019s disease activity: endoscopy, fecal markers and computed tomography enterography"],"prefix":"10.1177","volume":"11","author":[{"given":"Susana","family":"Lopes","sequence":"first","affiliation":[{"name":"Gastroenterology Department, University of Porto, Centro Hospitalar S\u00e3o Jo\u00e3o, Alameda Prof. Hernani Monteiro, 4200-319 Porto, Portugal"}]},{"given":"Patr\u00edcia","family":"Andrade","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, University of Porto, Centro Hospitalar S\u00e3o Jo\u00e3o, Porto, Portugal"}]},{"given":"Joana","family":"Afonso","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, University of Porto, Porto, Portugal"}]},{"given":"Rui","family":"Cunha","sequence":"additional","affiliation":[{"name":"Radiology Department, University of Porto, Centro Hospitalar S\u00e3o Jo\u00e3o, Porto, Portugal"}]},{"given":"Eduardo","family":"Rodrigues-Pinto","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, University of Porto, Centro Hospitalar S\u00e3o Jo\u00e3o, Porto, Portugal"}]},{"given":"Isabel","family":"Ramos","sequence":"additional","affiliation":[{"name":"Radiology Department, University of Porto, Centro Hospitalar S\u00e3o Jo\u00e3o, Porto, Portugal"}]},{"given":"Guilherme","family":"Macedo","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, University of Porto, Centro Hospitalar S\u00e3o Jo\u00e3o, Porto, Portugal"}]},{"given":"Fernando","family":"Magro","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Centro Hospitalar S\u00e3o Jo\u00e3o, Porto, Portugal Department of Pharmacology and Therapeutics, University of Porto, Porto, 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