{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T07:08:37Z","timestamp":1775027317135,"version":"3.50.1"},"reference-count":37,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"GEDII - Grupo de Estudo da Doen\u00e7a Inflamat\u00f3ria Intestinal"},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PD\/BD\/142890\/2018"],"award-info":[{"award-number":["PD\/BD\/142890\/2018"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therap Adv Gastroenterol"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec><jats:title>Aims:<\/jats:title><jats:p> We aimed to describe the burden of rehospitalization in patients with inflammatory bowel disease (IBD), by evaluating rehospitalization rates, charges, and risk factors over 16\u2009years. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> We performed a retrospective analysis of all hospital discharges with a primary diagnosis of IBD in public hospitals between 2000 and 2015 in mainland Portugal from the Central Administration of the Health System (ACSS)\u2019s national registry. We collected data on patient, clinical, and healthcare charges. We used survival analysis to estimate the rate and risk factors of IBD-related rehospitalization. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> We found that 33% ( n\u2009=\u200915,931) of the IBD-related hospitalizations corresponded to rehospitalizations, which increased by 12% over 16\u2009years. However, IBD rehospitalization rate per 100,000 IBD patients decreased 2.5-fold between 2003 and 2015. Mean IBD-related rehospitalization charges were \u20ac14,589\/hospitalization-year in 2000 and \u20ac17,548 \/hospitalization-year in 2015, with total rehospitalization charges reaching \u20ac3.1\u2009million\/year by 2015. Overall, the 30-day rate of rehospitalization was 24% for Crohn\u2019s disease (CD) and 22.4% for ulcerative colitis (UC). Novel risk factors for rehospitalization include penetrating disease in CD patients {hazard ratio (HR) 1.34 [95% confidence interval (CI) 1.20\u20131.51], p\u2009&lt;\u20090.001} and colostomy in UC patients [HR 2.84 (95% CI 1.06\u20137.58)]. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> IBD-related rehospitalization should be closely monitored, and efforts to reduce its risk factors should be made to improve the quality of care and, consequently, to reduce the burden of IBD. <\/jats:p><\/jats:sec>","DOI":"10.1177\/1756284820923836","type":"journal-article","created":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T09:22:37Z","timestamp":1589966557000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Rehospitalization rates, costs, and risk factors for inflammatory bowel disease: a 16-year nationwide study"],"prefix":"10.1177","volume":"13","author":[{"given":"Mafalda","family":"Santiago","sequence":"first","affiliation":[{"name":"Center for Health Technology and Services Research (CINTESIS), Porto, Portugal"},{"name":"Portuguese Inflammatory Bowel Disease (IBD) Study Group (GEDII), Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2634-9668","authenticated-orcid":false,"given":"Fernando","family":"Magro","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Unit of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, Alameda Prof. Hern\u00e2ni Monteiro, Porto, 4200-319, Portugal"},{"name":"Portuguese Inflammatory Bowel Disease (IBD) Study Group (GEDII), Porto, Portugal"},{"name":"Department of Gastroenterology, S\u00e3o Jo\u00e3o Hospital Center, Porto, Portugal"},{"name":"Center for Drug Discovery and Innovative Medicines (MedInUP), University of Porto, Porto, Portugal"}]},{"given":"Lu\u00eds","family":"Correia","sequence":"additional","affiliation":[{"name":"Portuguese Inflammatory Bowel Disease (IBD) Study Group (GEDII), Porto, Portugal"},{"name":"Department of Gastroenterology, Hospital Santa Maria, University Hospital Center of Lisbon North, Lisbon, Portugal"}]},{"given":"Francisco","family":"Portela","sequence":"additional","affiliation":[{"name":"Portuguese Inflammatory Bowel Disease (IBD) Study Group (GEDII), Porto, Portugal"},{"name":"Department of Gastroenterology, University Hospital Center of Coimbra, Coimbra, Portugal"}]},{"given":"Paula","family":"Ministro","sequence":"additional","affiliation":[{"name":"Portuguese Inflammatory Bowel Disease (IBD) Study Group (GEDII), Porto, Portugal"},{"name":"Department of Gastroenterology, Tondela-Viseu Hospital Center, Viseu, Portugal"}]},{"given":"Paula","family":"Lago","sequence":"additional","affiliation":[{"name":"Portuguese Inflammatory Bowel Disease (IBD) Study Group (GEDII), Porto, Portugal"},{"name":"Department of Gastroenterology, Hospital Santo Ant\u00f3nio, University Hospital Center of Porto, Porto, Portugal"}]},{"given":"Eunice","family":"Trindade","sequence":"additional","affiliation":[{"name":"Portuguese Inflammatory Bowel Disease (IBD) Study Group (GEDII), Porto, Portugal"},{"name":"Department of Pediatrics, S\u00e3o Jo\u00e3o Hospital Center, Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9356-3272","authenticated-orcid":false,"given":"Cl\u00e1udia Camila","family":"Dias","sequence":"additional","affiliation":[{"name":"Center for Health Technology and Services Research (CINTESIS), Porto, Portugal"},{"name":"Department of Community Medicine, Information and Health Decision Sciences (MEDCIDS), Faculty of Medicine, University of Porto, 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