{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T07:51:04Z","timestamp":1772956264829,"version":"3.50.1"},"reference-count":129,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1177\/1933719116671002","type":"journal-article","created":{"date-parts":[[2016,9,28]],"date-time":"2016-09-28T00:50:18Z","timestamp":1475023818000},"page":"976-988","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Genomic and Nongenomic Effects of Mifepristone at the Cardiovascular Level: A Review"],"prefix":"10.1007","volume":"24","author":[{"given":"Joana","family":"Feiteiro","sequence":"first","affiliation":[]},{"given":"Melissa","family":"Mariana","sequence":"additional","affiliation":[]},{"given":"Ignacio","family":"Verde","sequence":"additional","affiliation":[]},{"given":"Elisa","family":"Cairr\u00e3o","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2020,1,23]]},"reference":[{"issue":"10","key":"24070976_CR1","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1517\/13543784.12.10.1693","volume":"12","author":"IM Spitz","year":"2003","unstructured":"Spitz IM. Progesterone antagonists and progesterone receptor modulators. Expert Opin Investig Drugs. 2003;12(10):1693\u20131707.","journal-title":"Expert Opin Investig Drugs"},{"issue":"3","key":"24070976_CR2","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0022-4731(85)90401-7","volume":"23","author":"D Gagne","year":"1985","unstructured":"Gagne D, Pons M, Philibert D. RU 38486: a potent antiglucocorti-coid in vitro and in vivo. J Steroid Biochem. 1985;23(3):247\u2013251.","journal-title":"J Steroid Biochem"},{"issue":"1","key":"24070976_CR3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.contraception.2009.08.004","volume":"81","author":"EA Schaff","year":"2010","unstructured":"Schaff EA. Mifepristone: ten years later. Contraception. 2010; 81(1):1\u20137.","journal-title":"Contraception"},{"issue":"5","key":"24070976_CR4","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.contraception.2009.12.012","volume":"82","author":"IM Spitz","year":"2010","unstructured":"Spitz IM. Mifepristone: where do we come from and where are we going? Clinical development over a quarter of a century. Contraception. 2010;82(5):442\u2013452.","journal-title":"Contraception"},{"issue":"1","key":"24070976_CR5","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0010-7824(99)00115-8","volume":"61","author":"JG Kahn","year":"2000","unstructured":"Kahn JG, Becker BJ, MacIsaa L, et al. The efficacy of medical abortion: a meta-analysis. Contraception. 2000;61(1):29\u201340.","journal-title":"Contraception"},{"issue":"3","key":"24070976_CR6","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.ijgo.2006.09.009","volume":"96","author":"NL Moreno-Ruiz","year":"2007","unstructured":"Moreno-Ruiz NL, Borgatta L, Yanow S, Kapp N, Wiebe ER, Winikoff B. Alternatives to mifepristone for early medical abor-tion. Int J Gynaecol Obstet. 2007;96(3):212\u2013218.","journal-title":"Int J Gynaecol Obstet"},{"issue":"1","key":"24070976_CR7","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.contraception.2012.06.011","volume":"87","author":"EG Raymond","year":"2013","unstructured":"Raymond EG, Shannon C, Weaver MA, Winikoff B. First-trimester medical abortion with mifepristone 200 mg and miso-prostol: a systematic review. Contraception. 2013;87(1):26\u201337.","journal-title":"Contraception"},{"issue":"3","key":"24070976_CR8","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3109\/09513590.2013.856410","volume":"30","author":"Y Sun","year":"2014","unstructured":"Sun Y, Fang M, Davies H, Hu Z. Mifepristone: a potential clinical agent based on its anti-progesterone and anti-glucocorticoid prop-erties. Gynecol Endocrinol. 2014;30(3):169\u2013173.","journal-title":"Gynecol Endocrinol"},{"issue":"6","key":"24070976_CR9","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0010-7824(03)00171-9","volume":"68","author":"R Sitruk-Ware","year":"2003","unstructured":"Sitruk-Ware R, Spitz IM. Pharmacological properties of mifepris-tone: toxicology and safety in animal and human studies. Contraception. 2003;68(6):409\u2013420.","journal-title":"Contraception"},{"issue":"8","key":"24070976_CR10","first-page":"3568","volume":"86","author":"JW Chu","year":"2001","unstructured":"Chu JW, Matthias DF, Belanoff J, Schatzberg A, Hoffman AR, Feldman D. Successful long-term treatment of refractory Cush-ing\u2019s disease with high-dose mifepristone (RU 486). J Clin Endocrinol Metab. 2001;86(8):3568\u20133573.","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"24070976_CR11","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1093\/humupd\/dmi002","volume":"11","author":"N Chabbert-Buffet","year":"2005","unstructured":"Chabbert-Buffet N, Meduri G, Bouchard P, Spitz IM. Selective progesterone receptor modulators and progesterone antagonists: mechanisms of action and clinical applications. Hum Reprod Update. 2005;11(3):293\u2013307.","journal-title":"Hum Reprod Update"},{"issue":"20","key":"24070976_CR12","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1016\/0024-3205(94)90017-5","volume":"54","author":"M Perusquia","year":"1994","unstructured":"Perusquia M, Kubli-Garfias C. Progesterone-like relaxant effect of RU 486 in the rat myometrium. Life Sci. 1994;54(20):1501\u20131506.","journal-title":"Life Sci"},{"issue":"26","key":"24070976_CR13","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1016\/S0024-3205(00)00590-7","volume":"66","author":"J Parra","year":"2000","unstructured":"Parra J, Cantabrana B, Hidalgo A. Mechanism of mifepristone-induced spasmolytic effect on isolated rat uterus. Life Sci. 2000;66(26):2563\u20132569.","journal-title":"Life Sci"},{"issue":"6","key":"24070976_CR14","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1177\/1933719115612926","volume":"23","author":"M Mariana","year":"2016","unstructured":"Mariana M, Feiteiro J, Cairrao E, Verde I. Mifepristone is a vaso-dilator due to the inhibition of smooth muscle cells L-type Ca2+ channels. Reprod Sci. 2016;23(6):723\u2013730.","journal-title":"Reprod Sci"},{"issue":"5","key":"24070976_CR15","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1002\/med.21311","volume":"34","author":"J Chen","year":"2014","unstructured":"Chen J, Wang J, Shao J, et al. The unique pharmacological char-acteristics of mifepristone (RU486): from terminating pregnancy to preventing cancer metastasis. Med Res Rev. 2014;34(5):979\u20131000.","journal-title":"Med Res Rev"},{"issue":"3","key":"24070976_CR16","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1517\/14656560903535880","volume":"11","author":"A Im","year":"2010","unstructured":"Im A, Appleman LJ. Mifepristone: pharmacology and clinical impact in reproductive medicine, endocrinology and oncology. Expert Opin Pharmacother. 2010;11(3):481\u2013488.","journal-title":"Expert Opin Pharmacother"},{"issue":"2","key":"24070976_CR17","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0010-7824(93)90004-Q","volume":"48","author":"YE Shi","year":"1993","unstructured":"Shi YE, Ye ZH, He CH, et al. Pharmacokinetic study of RU 486 and its metabolites after oral administration of single doses to pregnant and non-pregnant women. Contraception. 1993;48(2):133\u2013149.","journal-title":"Contraception"},{"issue":"5","key":"24070976_CR18","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/0010-7824(86)90056-9","volume":"34","author":"ML Swahn","year":"1986","unstructured":"Swahn ML, Wang G, Aedo AR, Cekan SZ, Bygdeman M. Plasma levels of antiprogestin RU 486 following oral administration to non-pregnant and early pregnant women. Contraception. 1986;34(5):469\u2013481.","journal-title":"Contraception"},{"issue":"1A","key":"24070976_CR19","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0022-4731(89)90008-3","volume":"32","author":"O Heikinheimo","year":"1989","unstructured":"Heikinheimo O. Pharmacokinetics of the antiprogesterone RU 486 in women during multiple dose administration. J Steroid Biochem. 1989;32(1A):21\u201325.","journal-title":"J Steroid Biochem"},{"issue":"2","key":"24070976_CR20","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0015-0282(16)60067-5","volume":"50","author":"JH Liu","year":"1988","unstructured":"Liu JH, Garzo VG, Yen SS. Pharmacodynamics of the antipro-gesterone RU486 in women after oral administration. Fertil Steril. 1988;50(2):245\u2013249.","journal-title":"Fertil Steril"},{"issue":"6","key":"24070976_CR21","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/S0010-7824(86)80017-8","volume":"34","author":"O Heikinheimo","year":"1986","unstructured":"Heikinheimo O, Tevilin M, Shoupe D, Croxatto H, Lahteenmaki P. Quantitation of RU 486 in human plasma by HPLC and RIA after column chromatography. Contraception. 1986;34(6):613\u2013624.","journal-title":"Contraception"},{"issue":"1","key":"24070976_CR22","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0010-7824(96)00116-3","volume":"54","author":"I Foldesi","year":"1996","unstructured":"Foldesi I, Falkay G, Kovacs L. Determination of RU486 (mife-pristone) in blood by radioreceptorassay; a pharmacokinetic study. Contraception. 1996;54(1):27\u201332.","journal-title":"Contraception"},{"issue":"suppl1","key":"24070976_CR23","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1093\/humrep\/9.suppl_1.126","volume":"9","author":"A Ulmann","year":"1994","unstructured":"Ulmann A, Silvestre L. RU486: the French experience. Hum Reprod. 1994;9(suppl 1): 126\u2013130.","journal-title":"Hum Reprod"},{"issue":"6903","key":"24070976_CR24","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1136\/bmj.307.6903.532","volume":"307","author":"Termination of pregnancy with reduced doses of mifepristone.","year":"1993","unstructured":"Termination of pregnancy with reduced doses of mifepristone. World Health Organisation Task Force on post-ovulatory methods of fertility regulation. BMJ. 1993;307(6903):532\u2013537.","journal-title":"BMJ"},{"issue":"suppl3","key":"24070976_CR25","first-page":"133","volume":"55","author":"H von Hertzen","year":"2000","unstructured":"von Hertzen H. Research on regimens for early medical abortion. J Am Med Womens Assoc. 2000;55(suppl 3):133\u2013136, 150.","journal-title":"J Am Med Womens Assoc"},{"key":"24070976_CR26","first-page":"2","volume":"11","author":"PF Van Look","year":"1989","unstructured":"Van Look PF, Bygdeman M. Antiprogestational steroids: a new dimension in human fertility regulation. Oxf Rev Reprod Biol. 1989;11:2\u201360.","journal-title":"Oxf Rev Reprod Biol"},{"issue":"2","key":"24070976_CR27","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0301-2115(01)00522-X","volume":"101","author":"NN Sarkar","year":"2002","unstructured":"Sarkar NN. Mifepristone: bioavailability, pharmacokinetics and use-effectiveness. Eur J Obstet Gynecol Reprod Biol. 2002;101(2):113\u2013120.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"6","key":"24070976_CR28","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0010-7824(03)00077-5","volume":"68","author":"O Heikinheimo","year":"2003","unstructured":"Heikinheimo O, Kekkonen R, Lahteenmaki P. The pharmacoki-netics of mifepristone in humans reveal insights into differential mechanisms of antiprogestin action. Contraception. 2003;68(6):421\u2013426.","journal-title":"Contraception"},{"issue":"5","key":"24070976_CR29","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/0006-2952(96)00357-7","volume":"52","author":"GR Jang","year":"1996","unstructured":"Jang GR, Wrighton SA, Ben\u00eat LZ. Identification of CYP3A4 as the principal enzyme catalyzing mifepristone (RU 486) oxidation in human liver microsomes. Biochem Pharmacol. 1996;52(5):753\u2013761.","journal-title":"Biochem Pharmacol"},{"issue":"1","key":"24070976_CR30","doi-asserted-by":"crossref","first-page":"7","DOI":"10.2165\/00003088-199733010-00002","volume":"33","author":"O Heikinheimo","year":"1997","unstructured":"Heikinheimo O. Clinical pharmacokinetics of mifepristone. Clin Pharmacokinet. 1997;33(1):7\u201317.","journal-title":"Clin Pharmacokinet"},{"issue":"1","key":"24070976_CR31","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3109\/07853899309147861","volume":"25","author":"O Heikinheimo","year":"1993","unstructured":"Heikinheimo O, Kekkonen R. Dose-response relationships of RU 486. Ann Med. 1993;25(1):71\u201376.","journal-title":"Ann Med"},{"issue":"3","key":"24070976_CR32","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1530\/acta.0.1230298","volume":"123","author":"O Heikinheimo","year":"1990","unstructured":"Heikinheimo O, Ylikorkala O, Turpeinen U, Lahteenmaki P. Pharmacokinetics of the antiprogesterone RU 486: no correlation to clinical performance of RU 486. Acta Endocrinol (Copenh). 1990;123(3):298\u2013304.","journal-title":"Acta Endocrinol (Copenh)"},{"issue":"5715","key":"24070976_CR33","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1126\/science.1106943","volume":"307","author":"CM Revankar","year":"2005","unstructured":"Revankar CM, Cimino DF, Sklar LA, Arterburn JB, Prossnitz ER. A transmembrane intracellular estrogen receptor mediates rapid cell signaling. Science. 2005;307(5715):1625\u20131630.","journal-title":"Science"},{"issue":"2","key":"24070976_CR34","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1210\/en.2004-1064","volume":"146","author":"P Thomas","year":"2005","unstructured":"Thomas P, Pang Y, Filardo EJ, Dong J. Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells. Endocrinology. 2005;146(2):624\u2013632.","journal-title":"Endocrinology"},{"issue":"6","key":"24070976_CR35","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1111\/j.1476-5381.2011.01235.x","volume":"163","author":"BO Nilsson","year":"2011","unstructured":"Nilsson BO, Olde B, Leeb-Lundberg LM. G protein-coupled oes-trogen receptor 1 (GPER1)\/GPR30: a new player in cardiovascu-lar and metabolic oestrogenic signalling. Br J Pharmacol. 2011;163(6):1131\u20131139.","journal-title":"Br J Pharmacol"},{"issue":"5","key":"24070976_CR36","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1097\/FJC.0000000000000060","volume":"63","author":"J Feiteiro","year":"2014","unstructured":"Feiteiro J, Santos-Silva AJ, Verde I, Cairrao E. Testosterone and atrial natriuretic peptide share the same pathway to induce vasor-elaxation of human umbilical artery. J Cardiovasc Pharmacol. 2014;63(5):461\u2013465.","journal-title":"J Cardiovasc Pharmacol"},{"issue":"17","key":"24070976_CR37","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1016\/0024-3205(90)90183-R","volume":"47","author":"M Perusquia","year":"1990","unstructured":"Perusquia M, Garcia-Yanez E, Ibanez R, Kubli-Garfias C. Non-genomic mechanism of action of delta-4 and 5-reduced androgens and progestins on the contractility of the isolated rat myometrium. Life Sci. 1990;47(17):1547\u20131553.","journal-title":"Life Sci"},{"issue":"5","key":"24070976_CR38","doi-asserted-by":"crossref","first-page":"G1008","DOI":"10.1152\/ajpgi.00382.2005","volume":"290","author":"ZL Xiao","year":"2006","unstructured":"Xiao ZL, Cao W, Biancani P, Behar J. Nongenomic effects of progesterone on the contraction of muscle cells from the guinea pig colon. Am J Physiol Gastrointest Liver Physiol. 2006;290(5): G1008\u2013G1015.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"4","key":"24070976_CR39","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0165-6147(91)90531-V","volume":"12","author":"BS McEwen","year":"1991","unstructured":"McEwen BS. Non-genomic and genomic effects of steroids on neural activity. Trends Pharmacol Sci. 1991;12(4):141\u2013147.","journal-title":"Trends Pharmacol Sci"},{"issue":"3","key":"24070976_CR40","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0024-3205(93)90678-V","volume":"53","author":"JA Sanchez Aparicio","year":"1993","unstructured":"Sanchez Aparicio JA, Gutierrez M, Hidalgo A, Cantabrana B. Effects of androgens on isolated rat uterus. Life Sci. 1993;53(3):269\u2013274.","journal-title":"Life Sci"},{"issue":"9","key":"24070976_CR41","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/0166-2236(90)90016-4","volume":"13","author":"M Schumacher","year":"1990","unstructured":"Schumacher M. Rapid membrane effects of steroid hormones: an emerging concept in neuroendocrinology. Trends Neurosci. 1990;13(9):359\u2013362.","journal-title":"Trends Neurosci"},{"issue":"2","key":"24070976_CR42","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/j.1476-5381.1988.tb11453.x","volume":"93","author":"D Bose","year":"1988","unstructured":"Bose D, Elliott D, Kobayashi T, Templeton JF, Kumar VP, LaBella FS. 14 beta-Hydroxyprogesterone binds to the digitalis receptor, inhibits the sodium pump and enhances cardiac contrac-tility. Br J Pharmacol. 1988;93(2):453\u2013461.","journal-title":"Br J Pharmacol"},{"issue":"6","key":"24070976_CR43","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/0306-3623(91)90581-P","volume":"22","author":"V Garcia Valencia","year":"1991","unstructured":"Garcia Valencia V, Sanchez M, Gutierrez M, Cantabrana B, Hidalgo A. Effects of steroidal and non-steroidal antiandrogens on the left atrium of the rat in vitro. Gen Pharmacol. 1991;22(6):1081\u20131086.","journal-title":"Gen Pharmacol"},{"issue":"1","key":"24070976_CR44","first-page":"57","volume":"281","author":"R Raddino","year":"1986","unstructured":"Raddino R, Manca C, Poli E, Bolognesi R, Visioli O. Effects of 17 beta-estradiol on the isolated rabbit heart. Arch Int Pharmacodyn Ther. 1986;281(1):57\u201365.","journal-title":"Arch Int Pharmacodyn Ther"},{"issue":"5","key":"24070976_CR45","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s00210-007-0213-3","volume":"376","author":"E Cairrao","year":"2008","unstructured":"Cairrao E, Alvarez E, Santos-Silva AJ, Verde I. Potassium chan-nels are involved in testosterone-induced vasorelaxation of human umbilical artery. Naunyn Schmiedebergs Arch Pharmacol. 2008;376(5):375\u2013383.","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"5","key":"24070976_CR46","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/aps.2012.4","volume":"33","author":"E Cairrao","year":"2012","unstructured":"Cairrao E, Alvarez E, Carvas JM, Santos-Silva AJ, Verde I. Non-genomic vasorelaxant effects of 17beta-estradiol and progesterone in rat aorta are mediated by L-type Ca2+ current inhibition. Acta Pharmacol Sin. 2012;33(5):615\u2013624.","journal-title":"Acta Pharmacol Sin"},{"key":"24070976_CR47","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1146\/annurev.physiol.67.040403.120151","volume":"67","author":"DP Edwards","year":"2005","unstructured":"Edwards DP. Regulation of signal transduction pathways by estrogen and progesterone. Annu Rev Physiol. 2005;67:335\u2013376.","journal-title":"Annu Rev Physiol"},{"issue":"1","key":"24070976_CR48","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0306-3623(94)90029-9","volume":"25","author":"R Cabrai","year":"1994","unstructured":"Cabrai R, Gutierrez M, Fernandez AI, Cantabrana B, Hidalgo A. Progesterone and pregnanolone derivatives relaxing effect on smooth muscle. Gen Pharmacol. 1994;25(1):173\u2013178.","journal-title":"Gen Pharmacol"},{"issue":"2","key":"24070976_CR49","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0306-3623(92)90026-G","volume":"23","author":"AI Fernandez","year":"1992","unstructured":"Fernandez AI, Cantabrana B, Hidalgo A. Mediators involved in the rat uterus contraction in calcium-free solution. Gen Pharmacol. 1992;23(2):291\u2013296.","journal-title":"Gen Pharmacol"},{"issue":"3","key":"24070976_CR50","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/0306-3623(92)90126-5","volume":"23","author":"AI Fernandez","year":"1992","unstructured":"Fernandez AI, Martinez V, Cantabrana B, Hidalgo A. Differential effect of calcium and Bay K 8644 on the inhibitory action of estrogens in the rat uterus. Gen Pharmacol. 1992;23(3):549\u2013554.","journal-title":"Gen Pharmacol"},{"issue":"1","key":"24070976_CR51","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0306-3623(94)00179-Q","volume":"26","author":"FM Goyache","year":"1995","unstructured":"Goyache FM, Gutierrez M, Hidalgo A, Cantabrana B. Non-genomic effects of catecholestrogens in the in vitro rat uterine contraction. Gen Pharmacol. 1995;26(1):219\u2013223s.","journal-title":"Gen Pharmacol"},{"issue":"6","key":"24070976_CR52","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/0024-3205(94)90055-8","volume":"55","author":"M Gutierrez","year":"1994","unstructured":"Gutierrez M, Martinez V, Cantabrana B, Hidalgo A. Genomic and non-genomic effects of steroidal drugs on smooth muscle contrac-tion in vitro. Life Sci. 1994;55(6):437\u2013443.","journal-title":"Life Sci"},{"issue":"1\u20132","key":"24070976_CR53","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0014-2999(94)90056-6","volume":"258","author":"E Salas","year":"1994","unstructured":"Salas E, Lopez MG, Villarroya M, et al. Endothelium-independent relaxation by 17-alpha-estradiol of pig coronary arteries. Eur J Pharmacol. 1994;258(1\u20132):47\u201355.","journal-title":"Eur J Pharmacol"},{"key":"24070976_CR54","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0079-6123(08)64426-X","volume":"61","author":"RL Moss","year":"1984","unstructured":"Moss RL, Dudley CA. Molecular aspects of the interaction between estrogen and the membrane excitability of hypothalamic nerve cells. Prog Brain Res. 1984;61:3\u201322.","journal-title":"Prog Brain Res"},{"issue":"1","key":"24070976_CR55","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0002-9378(89)90084-7","volume":"160","author":"JP Wolf","year":"1989","unstructured":"Wolf JP, Sinosich M, Anderson TL, Ulmann A, Baulieu EE, Hodgen GD. Progesterone antagonist (RU 486) for cervical dilation, labor induction, and delivery in monkeys: effectiveness in combination with oxytocin. Am J Obstet Gynecol. 1989;160(1):45\u201347.","journal-title":"Am J Obstet Gynecol"},{"issue":"6","key":"24070976_CR56","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/S0002-9378(87)80249-1","volume":"157","author":"GJ Haluska","year":"1987","unstructured":"Haluska GJ, Stanczyk FZ, Cook MJ, Novy MJ. Temporal changes in uterine activity and prostaglandin response to RU486 in rhesus macaques in late gestation. Am J Obstet Gynecol. 1987;157(6):1487\u20131495.","journal-title":"Am J Obstet Gynecol"},{"issue":"10\u201311","key":"24070976_CR57","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.steroids.2009.05.002","volume":"74","author":"M Perusquia","year":"2009","unstructured":"Perusquia M, Espinoza J, Navarrete E. Nongenomic uterine relax-ing effect of RU 486 (mifepristone) prior to its antiprogesterone activity in the human pregnancy. Steroids. 2009;74(10\u201311): 825\u2013831.","journal-title":"Steroids"},{"issue":"1","key":"24070976_CR58","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0960-0760(96)00091-X","volume":"59","author":"C Lobaccaro-Henri","year":"1996","unstructured":"Lobaccaro-Henri C, Descomps B, Thaler-Dao H. RU 38486 inhi-bits intracellular calcium mobilization and PGI2 release from human myometrium: mechanisms of action. J Steroid Biochem Mol Biol. 1996;59(1):63\u201373.","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"5","key":"24070976_CR59","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/0090-6980(92)90139-K","volume":"44","author":"C Lobaccaro-Henri","year":"1992","unstructured":"Lobaccaro-Henri C, Saintot M, Laffargue F, Zahradnik HP, Des-comps B, Thaler-Dao H. Effect of the progesterone antagonist RU486 on human myometrial spontaneous contractility and PGI2 release. Prostaglandins. 1992;44(5):443\u2013455.","journal-title":"Prostaglandins"},{"issue":"26","key":"24070976_CR60","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1016\/S0024-3205(01)01089-X","volume":"68","author":"M Perusquia","year":"2001","unstructured":"Perusquia M, Jasso-Kamel J. Influence of 5alpha- and 5beta-reduced progestins on the contractility of isolated human myome-trium at term. Life Sci. 2001;68(26):2933\u20132944.","journal-title":"Life Sci"},{"issue":"2","key":"24070976_CR61","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1095\/biolreprod.104.036954","volume":"73","author":"M Perusquia","year":"2005","unstructured":"Perusquia M, Navarrete E, Jasso-Kamel J, Montano LM. Andro-gens induce relaxation of contractile activity in pregnant human myometrium at term: a nongenomic action on L-type calcium channels. Biol Reprod. 2005;73(2):214\u2013221.","journal-title":"Biol Reprod"},{"issue":"12","key":"24070976_CR62","first-page":"732","volume":"32","author":"X Jiang","year":"1997","unstructured":"Jiang X, Wang H, Zhang Z. Determination of fetal umbilical artery flow velocity during induction of term labor by mifepris-tone [in Chinese]. Zhonghua Fu Chan Ke Za Zhi. 1997;32(12):732\u2013734.","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"issue":"6","key":"24070976_CR63","first-page":"349","volume":"33","author":"X Yang","year":"1998","unstructured":"Yang X, Li M, Feng S. Effects of mifepristone on the serum nitric oxide level and uterine blood flow in early pregnant women [in Chinese]. Zhonghua Fu Chan Ke Za Zhi. 1998;33(6):349\u2013351.","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"issue":"2","key":"24070976_CR64","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.contraception.2010.12.009","volume":"84","author":"M Perusquia","year":"2011","unstructured":"Perusquia M, Espinoza J, de la Pena A. Mifepristone (RU 486) induces vasodilation and inhibits platelet aggregation: nongenomic and genomic action to cause hemorrhage. Contraception. 2011;84(2):169\u2013177.","journal-title":"Contraception"},{"issue":"2","key":"24070976_CR65","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1172\/JCI119540","volume":"100","author":"JE Freedman","year":"1997","unstructured":"Freedman JE, Loscalzo J, Barnard MR, Alpert C, Keaney JF, Michelson AD. Nitric oxide released from activated platelets inhibits platelet recruitment. J Clin Invest. 1997;100(2):350\u2013356.","journal-title":"J Clin Invest"},{"issue":"6","key":"24070976_CR66","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1161\/01.ATV.13.6.791","volume":"13","author":"DI Simon","year":"1993","unstructured":"Simon DI, Stamler JS, Jaraki O, et al. Antiplatelet properties of protein S-nitrosothiols derived from nitric oxide and endothelium-derived relaxing factor. Arterioscler Thromb. 1993;13(6):791\u2013799.","journal-title":"Arterioscler Thromb"},{"issue":"6","key":"24070976_CR67","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1056\/NEJM199308053290607","volume":"329","author":"IM Spitz","year":"1993","unstructured":"Spitz IM, Bardin CW. Mifepristone (RU 486)\u2014a modulator of progestin and glucocorticoid action. N Engl J Med. 1993;329(6):404\u2013412.","journal-title":"N Engl J Med"},{"key":"24070976_CR68","first-page":"291","volume":"54","author":"PH Giangrande","year":"1999","unstructured":"Giangrande PH, McDonnell DP. The A and B isoforms of the human progesterone receptor: two functionally different tran-scription factors encoded by a single gene. Recent Prog Horm Res. 1999;54:291\u2013313; discussion 313\u2013294.","journal-title":"Recent Prog Horm Res"},{"issue":"12","key":"24070976_CR69","doi-asserted-by":"crossref","first-page":"7940","DOI":"10.1073\/pnas.122225699","volume":"99","author":"Z Liu","year":"2002","unstructured":"Liu Z, Auboeuf D, Wong J, et al. Coactivator\/corepressor ratios modulate PR-mediated transcription by the selective receptor modulator RU486. Proc Natl Acad Sci USA. 2002;99(12):7940\u20137944.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"11","key":"24070976_CR70","first-page":"1379","volume":"10","author":"LL Wei","year":"1996","unstructured":"Wei LL, Hawkins P, Baker C, Norris B, Sheridan PL, Quinn PG. An amino-terminal truncated progesterone receptor isoform, PRc, enhances progestin-induced transcriptional activity. Mol Endocrinol. 1996;10(11):1379\u20131387.","journal-title":"Mol Endocrinol"},{"issue":"7","key":"24070976_CR71","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1210\/me.2009-0016","volume":"23","author":"CR Mendelson","year":"2009","unstructured":"Mendelson CR. Minireview: fetal-maternal hormonal signaling in pregnancy and labor. Mol Endocrinol. 2009;23(7):947\u2013954.","journal-title":"Mol Endocrinol"},{"issue":"4","key":"24070976_CR72","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1210\/me.2005-0242","volume":"20","author":"JC Condon","year":"2006","unstructured":"Condon JC, Hardy DB, Kovaric K, Mendelson CR. Up-regulation of the progesterone receptor (PR)-C isoform in laboring myome-trium by activation of nuclear factor-kappaB may contribute to the onset of labor through inhibition of PR function. Mol Endo-crinol. 2006;20(4):764\u2013775.","journal-title":"Mol Endo-crinol"},{"issue":"11","key":"24070976_CR73","doi-asserted-by":"crossref","first-page":"5872","DOI":"10.1210\/en.2008-0602","volume":"149","author":"A Samalecos","year":"2008","unstructured":"Samalecos A, Gellersen B. Systematic expression analysis and antibody screening do not support the existence of naturally occurring progesterone receptor (PR)-C, PR-M, or other truncated PR isoforms. Endocrinology. 2008;149(11):5872\u20135887.","journal-title":"Endocrinology"},{"issue":"4854","key":"24070976_CR74","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1126\/science.3283939","volume":"240","author":"RM Evans","year":"1988","unstructured":"Evans RM. The steroid and thyroid hormone receptor superfamily. Science. 1988;240(4854):889\u2013895.","journal-title":"Science"},{"issue":"2","key":"24070976_CR75","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1530\/rep.1.00189","volume":"128","author":"B Mulac-Jericevic","year":"2004","unstructured":"Mulac-Jericevic B, Conneely OM. Reproductive tissue selective actions of progesterone receptors. Reproduction. 2004;128(2):139\u2013146.","journal-title":"Reproduction"},{"issue":"6","key":"24070976_CR76","first-page":"2668","volume":"86","author":"OD Slayden","year":"2001","unstructured":"Slayden OD, Nayak NR, Burton KA, et al. Progesterone antago-nists increase androgen receptor expression in the rhesus macaque and human endometrium. J Clin Endocrinol Metab. 2001;86(6):2668\u20132679.","journal-title":"J Clin Endocrinol Metab"},{"issue":"10\u201311","key":"24070976_CR77","volume":"65","year":"2000","unstructured":"Chwalisz K, Brenner RM, Fuhrmann UU, Hess-Stumpp H, Elger W. Antiproliferative effects of progesterone antagonists and pro-gesterone receptor modulators on the endometrium. Steroids. 2000;65(10\u201311):741-751.","journal-title":"Steroids"},{"issue":"suppl1","key":"24070976_CR78","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1093\/humrep\/9.suppl_1.77","volume":"9","author":"GD Hodgen","year":"1994","unstructured":"Hodgen GD, van Uem JF, Chillik CF, et al. Non-competitive anti-oestrogenic activity of progesterone antagonists in primate mod-els. Hum Reprod. 1994;9(suppl 1):77\u201381.","journal-title":"Hum Reprod"},{"issue":"7","key":"24070976_CR79","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1093\/oxfordjournals.humrep.a019433","volume":"11","author":"J Neulen","year":"1996","unstructured":"Neulen J, Williams RF, Breckwoldt M, Chwalisz K, Baulieu EE, Hodgen GD. Non-competitive anti-oestrogenic actions of proges-terone antagonists in primate endometrium: enhancement of oes-trogen and progesterone receptors with blockade of post-receptor proliferative mechanisms. Hum Reprod. 1996;11(7):1533\u20131537.","journal-title":"Hum Reprod"},{"issue":"2","key":"24070976_CR80","first-page":"440","volume":"78","author":"OD Slayden","year":"1994","unstructured":"Slayden OD, Brenner RM. RU 486 action after estrogen priming in the endometrium and oviducts of rhesus monkeys (Macaca mulatta). J Clin Endocrinol Metab. 1994;78(2):440\u2013448.","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"24070976_CR81","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1093\/humrep\/13.2.269","volume":"13","author":"OD Slayden","year":"1998","unstructured":"Slayden OD, Zelinski-Wooten MB, Chwalisz K, Stouffer RL, Brenner RM. Chronic treatment of cycling rhesus monkeys with low doses ofthe antiprogestin ZK 137 316: morphometric assess-ment of the uterus and oviduct. Hum Reprod. 1998;13(2):269\u2013277.","journal-title":"Hum Reprod"},{"issue":"2","key":"24070976_CR82","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1530\/rep.0.1240167","volume":"124","author":"RM Brenner","year":"2002","unstructured":"Brenner RM, Slayden OD, Critchley HO. Anti-proliferative effects of progesterone antagonists in the primate endometrium: a potential role for the androgen receptor. Reproduction. 2002;124(2):167\u2013172.","journal-title":"Reproduction"},{"issue":"3","key":"24070976_CR83","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1128\/MCB.18.3.1369","volume":"18","author":"BL Wagner","year":"1998","unstructured":"Wagner BL, Norris JD, Knotts TA, Weigel NL, McDonnell DP. The nuclear corepressors NCoR and SMRT are key regulators of both ligand- and 8-bromo-cyclic AMP-dependent transcriptional activity ofthe human progesterone receptor. Mol Cell Biol. 1998;18(3):1369\u20131378.","journal-title":"Mol Cell Biol"},{"issue":"5","key":"24070976_CR84","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1210\/me.2006-0524","volume":"21","author":"KP Madauss","year":"2007","unstructured":"Madauss KP, Grygielko ET, Deng SJ, et al. A structural and in vitro characterization of asoprisnil: a selective progesterone receptor modulator. Mol Endocrinol. 2007;21(5):1066\u20131081.","journal-title":"Mol Endocrinol"},{"issue":"10\u201311","key":"24070976_CR85","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S0039-128X(00)00180-X","volume":"65","author":"I Classen-Linke","year":"2000","unstructured":"Classen-Linke I, Alfer J, Krusche CA, Chwalisz K, Rath W, Beier HM. Progestins, progesterone receptor modulators, and progesterone antagonists change VEGF release of endometrial cells in culture. Steroids. 2000;65(10\u201311):763\u2013771.","journal-title":"Steroids"},{"issue":"12","key":"24070976_CR86","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1345\/aph.1K351","volume":"41","author":"RP Miech","year":"2007","unstructured":"Miech RP. Pathopharmacology of excessive hemorrhage in mifepristone abortions. Ann Pharmacother. 2007;41(12):2002\u20132007.","journal-title":"Ann Pharmacother"},{"issue":"1","key":"24070976_CR87","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0010-7824(89)90019-X","volume":"39","author":"E Johannisson","year":"1989","unstructured":"Johannisson E, Oberholzer M, Swahn ML, Bygdeman M. Vas-cular changes in the human endometrium following the admin-istration of the progesterone antagonist RU 486. Contraception. 1989;39(1):103\u2013117.","journal-title":"Contraception"},{"issue":"1","key":"24070976_CR88","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1210\/jcem-59-1-25","volume":"59","author":"X Bertagna","year":"1984","unstructured":"Bertagna X, Bertagna C, Luton JP, Husson JM, Girard F. The new steroid analog RU 486 inhibits glucocorticoid action in man. J Clin Endocrinol Metab. 1984;59(1):25\u201328.","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"24070976_CR89","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1210\/jcem-61-6-1009","volume":"61","author":"RC Gaillard","year":"1985","unstructured":"Gaillard RC, Poffet D, Riondel AM, Saurat JH. RU 486 inhibits peripheral effects of glucocorticoids in humans. J Clin Endocrinol Metab. 1985;61(6):1009\u20131011.","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"24070976_CR90","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0010-7824(85)90115-5","volume":"32","author":"M Bygdeman","year":"1985","unstructured":"Bygdeman M, Swahn ML. Progesterone receptor blockage. Effect on uterine contractility and early pregnancy. Contraception. 1985;32(1):45\u201351.","journal-title":"Contraception"},{"issue":"5","key":"24070976_CR91","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1093\/oxfordjournals.humrep.a138124","volume":"8","author":"L Cheng","year":"1993","unstructured":"Cheng L, Kelly RW, Thong KJ, Hume R, Baird DT. The effects of mifepristone (RU486) on prostaglandin dehydrogenase in decidual and chorionic tissue in early pregnancy. Hum Reprod. 1993;8(5):705\u2013709.","journal-title":"Hum Reprod"},{"issue":"8","key":"24070976_CR92","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1093\/humrep\/del141","volume":"21","author":"M Vaisanen-Tommiska","year":"2006","unstructured":"Vaisanen-Tommiska M, Butzow R, Ylikorkala O, Mikkola TS. Mifepristone-induced nitric oxide release and expression of nitric oxide synthases in the human cervix during early pregnancy. Hum Reprod. 2006;21(8):2180\u20132184.","journal-title":"Hum Reprod"},{"issue":"3","key":"24070976_CR93","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.jmig.2005.01.022","volume":"12","author":"SH Eisinger","year":"2005","unstructured":"Eisinger SH, Bonfiglio T, Fiscella K, Meldrum S, Guzick DS. Twelve-month safety and efficacy of low-dose mifepristone for uterine myomas. J Minim Invasive Gynecol. 2005;12(3):227\u2013233.","journal-title":"J Minim Invasive Gynecol"},{"issue":"6","key":"24070976_CR94","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1016\/j.fertnstert.2005.05.056","volume":"84","author":"IM Spitz","year":"2005","unstructured":"Spitz IM, Grunberg SM, Chabbert-Buffet N, Lindenberg T, Gelber H, Sitruk-Ware R. Management of patients receiving long-term treatment with mifepristone. Fertil Steril. 2005;84(6):1719\u20131726.","journal-title":"Fertil Steril"},{"issue":"6","key":"24070976_CR95","doi-asserted-by":"crossref","first-page":"861","DOI":"10.3171\/jns.1991.74.6.0861","volume":"74","author":"SM Grunberg","year":"1991","unstructured":"Grunberg SM, Weiss MH, Spitz IM, et al. Treatment of unre-sectable meningiomas with the antiprogesterone agent mifepris-tone. J Neurosurg. 1991;74(6):861\u2013866.","journal-title":"J Neurosurg"},{"issue":"suppl1","key":"24070976_CR96","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1093\/humrep\/9.suppl_1.202","volume":"9","author":"SM Grunberg","year":"1994","unstructured":"Grunberg SM. Role of antiprogestational therapy for meningio-mas. Hum Reprod. 1994;9(suppl 1):202\u2013207.","journal-title":"Hum Reprod"},{"issue":"9","key":"24070976_CR97","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1093\/humrep\/del182","volume":"21","author":"N Narvekar","year":"2006","unstructured":"Narvekar N, Critchley HO, Cheng L, Baird DT. Mifepristone-induced amenorrhoea is associated with an increase in micro-vessel density and glucocorticoid receptor and a decrease in stromal vascular endothelial growth factor. Hum Reprod. 2006;21(9):2312\u20132318.","journal-title":"Hum Reprod"},{"issue":"11","key":"24070976_CR98","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1093\/oxfordjournals.humrep.a019151","volume":"11","author":"ST Cameron","year":"1996","unstructured":"Cameron ST, Critchley HO, Thong KJ, Buckley CH, Williams AR, Baird DT. Effects of daily low dose mifepristone on endo-metrial maturation and proliferation. Hum Reprod. 1996;11(11):2518\u20132526.","journal-title":"Hum Reprod"},{"issue":"2","key":"24070976_CR99","first-page":"375","volume":"78","author":"X Bertagna","year":"1994","unstructured":"Bertagna X, Escourolle H, Pinquier JL, et al. Administration of RU 486 for 8 days in normal volunteers: antiglucocorticoid effect with no evidence of peripheral Cortisol deprivation. J Clin Endocrinol Metab. 1994;78(2):375\u2013380.","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"24070976_CR100","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.contraception.2006.03.016","volume":"74","author":"R Sitruk-Ware","year":"2006","unstructured":"Sitruk-Ware R. Mifepristone and misoprostol sequential regimen side effects, complications and safety. Contraception. 2006;74(1):48\u201355.","journal-title":"Contraception"},{"issue":"12","key":"24070976_CR101","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/j.biopsych.2006.05.034","volume":"60","author":"C DeBattista","year":"2006","unstructured":"DeBattista C, Belanoff J, Glass S, et al. Mifepristone versus placebo in the treatment of psychosis in patients with psychotic major depression. Biol Psychiatry. 2006;60(12):1343\u20131349.","journal-title":"Biol Psychiatry"},{"issue":"5","key":"24070976_CR102","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1530\/EJE-07-0458","volume":"157","author":"S Johanssen","year":"2007","unstructured":"Johanssen S, Allolio B. Mifepristone (RU 486) in Cushing\u2019s syndrome. Eur J Endocrinol. 2007;157(5):561\u2013569.","journal-title":"Eur J Endocrinol"},{"issue":"3","key":"24070976_CR103","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.antiviral.2006.06.008","volume":"72","author":"EA Schafer","year":"2006","unstructured":"Schafer EA, Venkatachari NJ, Ayyavoo V. Antiviral effects of mifepristone on human immunodeficiency virus type-1 (HIV-1): targeting Vpr and its cellular partner, the glucocorticoid receptor (GR). Antiviral Res. 2006;72(3):224\u2013232.","journal-title":"Antiviral Res"},{"issue":"7","key":"24070976_CR104","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.psyneuen.2010.01.011","volume":"35","author":"AC Wulsin","year":"2010","unstructured":"Wulsin AC, Herman JP, Solomon MB. Mifepristone decreases depression-like behavior and modulates neuroendocrine and cen-tral hypothalamic-pituitary-adrenocortical axis responsiveness to stress. Psychoneuroendocrinology. 2010;35(7):1100\u20131112.","journal-title":"Psychoneuroendocrinology"},{"issue":"4","key":"24070976_CR105","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1097\/JCP.0b013e3182239191","volume":"31","author":"CM Blasey","year":"2011","unstructured":"Blasey CM, Block TS, Belanoff JK, Roe RL. Efficacy and safety of mifepristone for the treatment of psychotic depression. J Clin Psychopharmacol. 2011;31(4):436\u2013440.","journal-title":"J Clin Psychopharmacol"},{"issue":"12","key":"24070976_CR106","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1038\/oby.2010.51","volume":"18","author":"C Gross","year":"2010","unstructured":"Gross C, Blasey CM, Roe RL, Belanoff JK. Mifepristone reduces weight gain and improves metabolic abnormalities asso-ciated with risperidone treatment in normal men. Obesity (Silver Spring). 2010;18(12):2295\u20132300.","journal-title":"Obesity (Silver Spring)"},{"issue":"10","key":"24070976_CR107","first-page":"959","volume":"26","author":"C Gross","year":"2009","unstructured":"Gross C, Blasey CM, Roe RL, Allen K, Block TS, Belanoff JK. Mifepristone treatment of olanzapine-induced weight gain in healthy men. Adv Titer. 2009;26(10):959\u2013969.","journal-title":"Adv Titer"},{"issue":"3","key":"24070976_CR108","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/phar.1202","volume":"33","author":"FH Morgan","year":"2013","unstructured":"Morgan FH, Laufgraben MJ. Mifepristone for management of Cushing\u2019s syndrome. Pharmacotherapy. 2013;33(3):319\u2013329.","journal-title":"Pharmacotherapy"},{"issue":"4","key":"24070976_CR109","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1097\/MED.0b013e32835430bf","volume":"19","author":"F Castinetti","year":"2012","unstructured":"Castinetti F, Brue T, Conte-Devolx B. The use of the glucocor-ticoid receptor antagonist mifepristone in Cushing\u2019s syndrome. Curr Opin Endocrinol Diabetes Obes. 2012;19(4):295\u2013299.","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"24070976_CR110","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1146\/annurev.ne.02.030179.000433","volume":"2","author":"BS McEwen","year":"1979","unstructured":"McEwen BS, Davis PG, Parsons B, Pfaff DW. The brain as a target for steroid hormone action. Annu Rev Neurosci. 1979;2:65\u2013112.","journal-title":"Annu Rev Neurosci"},{"issue":"1\u20132","key":"24070976_CR111","volume":"19","year":"2002","unstructured":"Belanoff JK, Jurik J, Schatzberg LD, DeBattista C, Schatzberg AF. Slowing the progression of cognitive decline in Alzheimer\u2019s disease using mifepristone. J Mol Neurosci. 2002;19(1\u20132):201-206.","journal-title":"J Mol Neurosci"},{"key":"24070976_CR112","first-page":"436","volume":"10","author":"RE Garfield","year":"1988","unstructured":"Garfield RE, Blennerhassett MG, Miller SM. Control of myo-metrial contractility: role and regulation of gap junctions. Oxf Rev Reprod Biol. 1988;10:436\u2013490.","journal-title":"Oxf Rev Reprod Biol"},{"issue":"12","key":"24070976_CR113","doi-asserted-by":"crossref","first-page":"e80114","DOI":"10.1371\/journal.pone.0080114","volume":"8","author":"M Engman","year":"2013","unstructured":"Engman M, Varghese S, Lagerstedt Robinson K, et al. GSTM1 gene expression correlates to leiomyoma volume regression in response to mifepristone treatment. PLoS One. 2013;8(12):e80114.","journal-title":"PLoS One"},{"issue":"1","key":"24070976_CR114","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.contraception.2010.12.001","volume":"84","author":"Y Chen","year":"2011","unstructured":"Chen Y, Wang W, Zhuang Y, Chen X, Huang L. Effects of low-dose mifepristone administration in two different 14-day regi-mens on the menstrual cycle and endometrial development: a randomized controlled trial. Contraception. 2011;84(1):64\u201370.","journal-title":"Contraception"},{"issue":"5","key":"24070976_CR115","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.fertnstert.2011.08.021","volume":"96","author":"P Bouchard","year":"2011","unstructured":"Bouchard P, Chabbert-Buffet N, Fauser BC. Selective proges-terone receptor modulators in reproductive medicine: pharma-cology, clinical efficacy and safety. Fertil Steril. 2011;96(5):1175\u20131189.","journal-title":"Fertil Steril"},{"issue":"1","key":"24070976_CR116","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0015-0282(16)58022-4","volume":"65","author":"LM Kettel","year":"1996","unstructured":"Kettel LM, Murphy AA, Morales AJ, Ulmann A, Baulieu EE, Yen SS. Treatment of endometriosis with the antiprogesterone mifepristone (RU486). Fertil Steril. 1996;65(1):23\u201328.","journal-title":"Fertil Steril"},{"issue":"6","key":"24070976_CR117","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1136\/jnnp.55.6.486","volume":"55","author":"SW Lamberts","year":"1992","unstructured":"Lamberts SW, Tanghe HL, Avezaat CJ, et al. Mifepristone (RU 486) treatment of meningiomas. J Neurol Neurosurg Psychiatry. 1992;55(6):486\u2013490.","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"10\u201311","key":"24070976_CR118","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/S0039-128X(00)00195-1","volume":"65","author":"JG Klijn","year":"2000","unstructured":"Klijn JG, Setyono-Han B, Foekens JA. Progesterone antagonists and progesterone receptor modulators in the treatment of breast cancer. Steroids. 2000;65(10\u201311):825\u2013830.","journal-title":"Steroids"},{"issue":"9","key":"24070976_CR119","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1111\/j.1464-410X.2008.07509.x","volume":"101","author":"ME Taplin","year":"2008","unstructured":"Taplin ME, Manola J, Oh WK, et al. A phase II study of mife-pristone (RU-486) in castration-resistant prostate cancer, with a correlative assessment of androgen-related hormones. BJU Int. 2008;101(9):1084\u20131089.","journal-title":"BJU Int"},{"issue":"1","key":"24070976_CR120","first-page":"167","volume":"18","author":"RD Wiehle","year":"2007","unstructured":"Wiehle RD, Christov K, Mehta R. Anti-progestins suppress the growth of established tumors induced by 7,12-dimethylben-z(a)anthracene: comparison between RU486 and a new 21-sub-stituted-19-nor-progestin. Oncol Rep. 2007;18(1):167\u2013174.","journal-title":"Oncol Rep"},{"issue":"3","key":"24070976_CR121","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.jsbmb.2003.12.004","volume":"88","author":"BJ Attardi","year":"2004","unstructured":"Attardi BJ, Burgenson J, Hild SA, Reel JR. In vitro antiprogesta-tional\/antiglucocorticoid activity and progestin and glucocorticoid receptor binding of the putative metabolites and synthetic derivatives of CDB-2914, CDB-4124, and mifepristone. J Steroid Biochem Mol Biol. 2004;88(3):277\u2013288.","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"9","key":"24070976_CR122","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1093\/humrep\/den228","volume":"23","author":"M Engman","year":"2008","unstructured":"Engman M, Skoog L, Soderqvist G, Gemzell-Danielsson K. The effect of mifepristone on breast cell proliferation in premeno-pausal women evaluated through fine needle aspiration cytology. Hum Reprod. 2008;23(9):2072\u20132079.","journal-title":"Hum Reprod"},{"issue":"5804","key":"24070976_CR123","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1126\/science.1130471","volume":"314","author":"AJ Poole","year":"2006","unstructured":"Poole AJ, Li Y, Kim Y, Lin SC, Lee WH, Lee EY. Prevention of Brcal-mediated mammary tumorigenesis in mice by a proges-terone antagonist. Science. 2006;314(5804):1467\u20131470.","journal-title":"Science"},{"issue":"2","key":"24070976_CR124","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1210\/jc.2002-021763","volume":"88","author":"OD Slayden","year":"2003","unstructured":"Slayden OD, Brenner RM. Flutamide counteracts the antiproli-ferative effects of antiprogestins in the primate endometrium. J Clin Endocrinol Metab. 2003;88(2):946\u2013949.","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"24070976_CR125","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1016\/S0002-9378(87)80236-3","volume":"157","author":"D M D J Shoupe","year":"1987","unstructured":"Shoupe D, Mishell DR Jr, Page MA, Madkour H, Spitz IM, Lobo RA. Effects of the antiprogesterone RU 486 in normal women. II. Administration in the late follicular phase. Am J Obstet Gynecol. 1987;157(6):1421\u20131426.","journal-title":"Am J Obstet Gynecol"},{"issue":"48","key":"24070976_CR126","first-page":"6536","volume":"162","author":"TB Lindhardt","year":"2000","unstructured":"Lindhardt TB, Walker LR, Colov NS, Hansen PS. Vasospastic angina pectoris following abortion induced by prostaglandin analogue. Ugeskr Laeger. 2000;162(48):6536\u20136537.","journal-title":"Ugeskr Laeger"},{"issue":"4","key":"24070976_CR127","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1038\/sj.bjp.0702393","volume":"126","author":"L Walch","year":"1999","unstructured":"Walch L, Labat C, Gascard JP, de Montpreville V, Brink C, Norel X. Prostanoid receptors involved in the relaxation of human pulmonary vessels. Br J Pharmacol. 1999;126(4):859\u2013866.","journal-title":"Br J Pharmacol"},{"issue":"5","key":"24070976_CR128","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1067\/mob.2000.108886","volume":"183","author":"PS Ramsey","year":"2000","unstructured":"Ramsey PS, Hogg BB, Savage KG, Winkler DD, Owen J. Cardiovascular effects of intravaginal misoprostol in the mid trimester of pregnancy. Am J Obstet Gynecol. 2000;183(5):1100\u20131102.","journal-title":"Am J Obstet Gynecol"},{"issue":"1","key":"24070976_CR129","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.contraception.2006.03.003","volume":"74","author":"A Davey","year":"2006","unstructured":"Davey A. Mifepristone and prostaglandin for termination of pregnancy: contraindications for use, reasons and rationale. Contraception. 2006;74(1):16\u201320.","journal-title":"Contraception"}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1177\/1933719116671002.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1933719116671002","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1177\/1933719116671002\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1933719116671002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1177\/1933719116671002.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,3]],"date-time":"2022-07-03T01:57:23Z","timestamp":1656813443000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1177\/1933719116671002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":129,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["24070976"],"URL":"https:\/\/doi.org\/10.1177\/1933719116671002","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"23 January 2020","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}