{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:02:21Z","timestamp":1777878141616,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Natural Product Communications"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:p>\n                    In this study, flowering aerial parts of wild Achillea millefolium growing on the Mediterranean coast (Sardinia Island, Italy) and on the Atlantic coast (Portugal- Serra de Montemuro) were used as a matrix for supercritical extraction of volatile oil with CO\n                    <jats:sub>2<\/jats:sub>\n                    (SFE). The collected extracts were analyzed by GC-FID and GC-MS methods and their composition were compared with that of the essential oil isolated by hydrodistillation. A strong chemical variability in essential oils depending on the origin of the samples was observed. The results showed the presence of two type oils. The Italian volatile extracts (SFE and essential oil) are predominantly composed by \u03b1-asarone (25.6-33.3%, in the SFE extract and in the HD oil, respectively), \u03b2-bisabolene (27.3-16.6%) and \u03b1-pinene (10.0-17.0%); whereas the main components of the Portuguese extracts are trans-thujone (31.4-29.0%), trans-crhysanthenyl acetate (19.8-15.8%) and \u03b2-pinene (1.2-11.1%).\n                  <\/jats:p>\n                  <jats:p>\n                    The minimal inhibitory concentration (MIC) and the minimal lethal concentration (MLC) were used to evaluate the antifungal activity of the oils against Candida albicans, C. tropicalis, C. krusei, C. guillermondii, C. parapsilosis, Cryptococcus neoformans, Trichophyton rubrum, T. mentagrophytes, T. mentagrophytes var. interdigitale, T. verrucosum, Microsporum canis, M. gypseum, Epidermophyton floccosum, Aspergillus niger, A. fumigatus and A. flavus. The oils showed the highest activity against dermatophyte strains, with MIC values ranging from 0.32-1.25 \u03bcL mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    .\n                  <\/jats:p>","DOI":"10.1177\/1934578x1100601030","type":"journal-article","created":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T06:43:42Z","timestamp":1553582622000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Chemical Composition and Biological Activity of the Volatile Extracts of\n                    <i>Achillea millefolium<\/i>"],"prefix":"10.1177","volume":"6","author":[{"given":"Danilo","family":"Falconieri","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze Chimiche, Universit\u00e0 degli Studi di Cagliari, Cittadella Universitaria di Monserrato, SS 554, Km 4.500, 09042 Cagliari, Italy"}]},{"given":"Alessandra","family":"Piras","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chimiche, Universit\u00e0 degli Studi di Cagliari, Cittadella Universitaria di Monserrato, SS 554, Km 4.500, 09042 Cagliari, Italy"}]},{"given":"Silvia","family":"Porcedda","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chimiche, Universit\u00e0 degli Studi di Cagliari, Cittadella Universitaria di Monserrato, SS 554, Km 4.500, 09042 Cagliari, Italy"}]},{"given":"Bruno","family":"Marongiu","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chimiche, Universit\u00e0 degli Studi di Cagliari, Cittadella Universitaria di Monserrato, SS 554, Km 4.500, 09042 Cagliari, Italy"}]},{"given":"Maria J.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Centro de Estudos Farmac\u00eauticos\/Faculdade de Farmacia, Universidade de Coimbra, 3000-548 Coimbra, Portugal"}]},{"given":"C\u00e9lia","family":"Cabral","sequence":"additional","affiliation":[{"name":"Centro de Estudos Farmac\u00eauticos\/Faculdade de Farmacia, Universidade de Coimbra, 3000-548 Coimbra, Portugal"}]},{"given":"Carlos","family":"Cavaleiro","sequence":"additional","affiliation":[{"name":"Centro de Estudos Farmac\u00eauticos\/Faculdade de Farmacia, Universidade de Coimbra, 3000-548 Coimbra, Portugal"}]},{"given":"Ligia","family":"Salgueiro","sequence":"additional","affiliation":[{"name":"Centro de Estudos Farmac\u00eauticos\/Faculdade de Farmacia, Universidade de Coimbra, 3000-548 Coimbra, Portugal"}]}],"member":"179","published-online":{"date-parts":[[2011,10,1]]},"reference":[{"key":"bibr1-1934578X1100601030","first-page":"51","author":"Burnie G.","year":"1999","journal-title":"K\u00f6nemann - Gordon Cheers Publication"},{"key":"bibr2-1934578X1100601030","doi-asserted-by":"publisher","DOI":"10.2174\/138161208786404281"},{"key":"bibr3-1934578X1100601030","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2006.07.014"},{"key":"bibr4-1934578X1100601030","first-page":"89","volume":"27","author":"H\u00e9thelyi \u00c9","year":"1988","journal-title":"Herba Hungarica"},{"key":"bibr5-1934578X1100601030","first-page":"168","volume":"13","author":"Mockute D","year":"2000","journal-title":"Chemya"},{"key":"bibr6-1934578X1100601030","doi-asserted-by":"publisher","DOI":"10.1177\/1934578X0700200417"},{"key":"bibr7-1934578X1100601030","doi-asserted-by":"publisher","DOI":"10.1080\/10412905.1993.9698242"},{"key":"bibr8-1934578X1100601030","doi-asserted-by":"publisher","DOI":"10.1080\/10412905.2005.9698978"},{"key":"bibr9-1934578X1100601030","first-page":"346","volume":"5","author":"Judzentiene A","year":"2010","journal-title":"Central European Journal of Biology"},{"key":"bibr10-1934578X1100601030","first-page":"159","volume":"32","author":"Saukel J","year":"1992","journal-title":"Phyton (Horn)"},{"key":"bibr11-1934578X1100601030","doi-asserted-by":"publisher","DOI":"10.1007\/BF02858720"},{"key":"bibr12-1934578X1100601030","doi-asserted-by":"publisher","DOI":"10.1080\/10915810160233785"},{"key":"bibr13-1934578X1100601030","unstructured":"TutinTG HeywoodWH BurgesNA MooreDM ValentineDH WaltersSM WebbDA. 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