{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:27:34Z","timestamp":1777876054596,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Natural Product Communications"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:p>\n                    Acantholippia salsoloides (Verbenaceae) is an aromatic plant widespread in the Andean region. The infusion (leaves and flowers) is widely used as a digestive stimulant as well as for the treatment of various diseases in traditional medicine. A. salsoloides attributes its common name \u201crica-rica\u201d to the fresh and sweet fragrance of the plant. In this work, 2 different polar extracts and the essential oil of a selected rica-rica population were studied. The phenolic composition was analyzed by high-performance liquid chromatography diode array detector; the essential oil profile was determined by gas-chromatography ion-trap mass spectrometry\/flame ionization detection. For all extracts, the antibacterial potential was performed by in vitro assays; the antioxidant and \u03b1-glucosidase inhibition were determined in decoction and hydroethanolic extracts. The volatile profile allowed the identification of 26 volatile compounds, \u03b2-thujone (84%) being the major one in this rica-rica population. Eighteen phenolic compounds were identified; isoferulic acid (16%-18%) and cynaroside (45%-47%) were the larger ones. In a general way, the hydroethanolic extract was more active against Staphylococcus aureus and Micrococcus luteus (minimum inhibitory concentrations= 0.3- 1.3 mg\/mL). Both polar extracts have strong antiradical activities although decoction extract proved to be more active against DPPH\n                    <jats:sup>\u00b7<\/jats:sup>\n                    (half-maximal inhibitory concentration [IC\n                    <jats:sub>50<\/jats:sub>\n                    ] =36 \u00b5g\/mL) and O\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>\u2022\u2212<\/jats:sup>\n                    (IC\n                    <jats:sub>50<\/jats:sub>\n                    =28 \u00b5g\/mL) while hydroethanolic extract shows higher action over \u03b1-glucosidase (IC\n                    <jats:sub>50<\/jats:sub>\n                    =217 \u00b5g\/mL). The results suggest that A. salsoloides leaves and flowers may be an interesting source of natural antioxidants, antidiabetics, or antimicrobials, and could be used in dietary supplements, medicinal products and pharmaceutical formulations.\n                  <\/jats:p>","DOI":"10.1177\/1934578x19858542","type":"journal-article","created":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T11:02:30Z","timestamp":1561460550000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Acantholippia salsoloides<\/i>\n                    : Phytochemical Composition and Biological Potential of a Thujonic Population"],"prefix":"10.1177","volume":"14","author":[{"given":"Liliana","family":"Celaya","sequence":"first","affiliation":[{"name":"Laboratorio PRONOA, CIITED- CONICET Universidad Nacional de Jujuy, Argentina"},{"name":"Departamento de Ingenier\u00eda Qu\u00edmica, FCEQyN-CONICET Universidad Nacional de Misiones, Posadas, Argentina"},{"name":"REQUIMTE\/Laborat\u00f3rio de Farmacognosia, Faculdade de Farm\u00e1cia, Universidade do Porto, Portugal"}]},{"given":"Carmen","family":"Viturro","sequence":"additional","affiliation":[{"name":"Laboratorio PRONOA, CIITED- CONICET Universidad Nacional de Jujuy, Argentina"}]},{"given":"Lu\u00eds R.","family":"Silva","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Universidade da Beira Interior, Covilh\u00e3, Portugal"}]}],"member":"179","published-online":{"date-parts":[[2019,6,25]]},"reference":[{"key":"bibr1-1934578X19858542","first-page":"7","volume":"3","author":"Caro J","year":"1982","journal-title":"Dominguezia"},{"key":"bibr2-1934578X19858542","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(01)00190-8"},{"key":"bibr3-1934578X19858542","doi-asserted-by":"publisher","DOI":"10.4067\/S0716-97602008000200004"},{"key":"bibr4-1934578X19858542","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2009.05.011"},{"key":"bibr5-1934578X19858542","first-page":"29","volume":"16","author":"Borgnia M.","year":"2006","journal-title":"Ecolog\u00eda Austral"},{"key":"bibr6-1934578X19858542","first-page":"75","volume":"28","author":"Celaya L.","year":"2012","journal-title":"Dominguezia"},{"key":"bibr7-1934578X19858542","first-page":"1","volume":"11","author":"Steibel PE","year":"2000","journal-title":"Revista de la Facultad de Agronom\u00eda"},{"key":"bibr8-1934578X19858542","doi-asserted-by":"publisher","DOI":"10.1080\/10412905.2009.9700204"},{"key":"bibr9-1934578X19858542","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2007.04.066"},{"key":"bibr10-1934578X19858542","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-010-2042-4"},{"issue":"17","key":"bibr11-1934578X19858542","first-page":"1","volume":"24","author":"Sampietro DA.","year":"2015","journal-title":"Nat Prod Res"},{"key":"bibr12-1934578X19858542","doi-asserted-by":"publisher","DOI":"10.1016\/j.postharvbio.2011.12.011"},{"key":"bibr13-1934578X19858542","first-page":"33","volume":"14","author":"Van-Baren CM.","year":"2015","journal-title":"Revista BLACPMA"},{"key":"bibr14-1934578X19858542","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2013.04.003"},{"key":"bibr15-1934578X19858542","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.201600227"},{"key":"bibr16-1934578X19858542","volume-title":"Identification of Essential Oil Components by Gas Chromatography\/Mass Spectrometry","author":"Adams RP","year":"2007","edition":"4"},{"key":"bibr17-1934578X19858542","unstructured":"Wiley\/NIST. 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