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The study and sample characteristics, LT intervention parameters and posttreatment outcomes were analyzed. Risk of bias was assessed using the Risk of Bias Assessment for Non-randomized Studies (RoBANS) tool.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Three\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      and 30\n                      <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                      studies were included. Most studies were judged as high risk of performance and detection bias. Biochemical outcomes were analyzed for both i\n                      <jats:italic toggle=\"yes\">n vitro<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                      studies, and histological and behavioral outcomes were analyzed for\n                      <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                      studies. LT reduced extracellular matrix (ECM) degradation, inflammation, and OA progression, promoting ECM synthesis. LT improved pain-like behavior in animal models, having no apparent effect on gait performance. There were conflicting findings of some of the biochemical, histological, and behavioral outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The included studies presented different strategies and LT parameters. LT resulted in positive effects on cartilage repair and may be an adequate therapy for OA treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/19476035211007902","type":"journal-article","created":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T14:00:24Z","timestamp":1618495224000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["<i>In Vitro<\/i>\n                    and\n                    <i>In Vivo<\/i>\n                    Effects of Light Therapy on Cartilage Regeneration for Knee Osteoarthritis: A Systematic Review"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9617-5910","authenticated-orcid":false,"given":"Sofia","family":"Oliveira","sequence":"first","affiliation":[{"name":"Center for Micro-ElectroMechanical Systems (CMEMS-UMINHO), University of Minho, Guimar\u00e3es, 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