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Employing microcarriers as cell-expansion vehicles is a promising bottom-up bone tissue engineering strategy. Here we propose a collaborative approach between experimental work and mathematical modelling to develop protocols for growing microcarrier-based engineered constructs of clinically relevant size. Experiments in 96-well plates characterise cell growth with the model human cell line MG-63 using four phosphate glass microcarrier materials. Three of the materials are doped with 5\u2009mol% TiO<jats:sub>2<\/jats:sub> and contain 0%, 2% or 5% CoO, and the fourth material is doped only with 7% TiO<jats:sub>2<\/jats:sub> (0% CoO). A mathematical model of cell growth is parameterised by finding material-specific growth coefficients through data-fitting against these experiments. The parameterised mathematical model offers more insight into the material performance by comparing culture outcome against clinically relevant criteria: maximising final cell number starting with the lowest cell number in the shortest time frame. Based on this analysis, material 7% TiO<jats:sub>2<\/jats:sub> is identified as the most promising. <\/jats:p>","DOI":"10.1177\/2041731419830264","type":"journal-article","created":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T13:23:26Z","timestamp":1551792206000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["A parameterised mathematical model to elucidate osteoblast cell growth in a phosphate-glass microcarrier culture"],"prefix":"10.1177","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3936-8673","authenticated-orcid":false,"given":"Iva","family":"Burova","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering, University College London, London, UK"}]},{"given":"Carlotta","family":"Peticone","sequence":"additional","affiliation":[{"name":"Department of Biochemical Engineering, University College London, London, UK"}]},{"given":"David","family":"De Silva Thompson","sequence":"additional","affiliation":[{"name":"Department of Biochemical Engineering, University College London, London, UK"}]},{"given":"Jonathan C","family":"Knowles","sequence":"additional","affiliation":[{"name":"Division of Biomaterials and Tissue Engineering, Eastman Dental Institute, University College London, London, UK"},{"name":"The Discoveries Centre for Regenerative and Precision Medicine, London, UK"},{"name":"Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan, Republic of Korea"},{"name":"UCL Eastman-Korea Dental Medicine Innovation Centre, Dankook University, Cheonan, Republic of Korea"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6294-8348","authenticated-orcid":false,"given":"Ivan","family":"Wall","sequence":"additional","affiliation":[{"name":"Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan, 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