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Thyroid dysfunction is common in heart failure (HF) and is associated with worse prognosis. In this review, we discuss the cardiovascular effects of thyroid hormones, the pathophysiology of HFpEF, the prognostic impact of thyroid function, and the potential of thyroid hormones for treatment of HFpEF. Thyroid hormones have a central role in cardiovascular homeostasis, improving cardiac function through genomic and non-genomic mechanisms. Both overt and subclinical hypothyroidism are associated with increased risk of HF. Even when plasmatic thyroid hormones levels are normal, patients with HF may have local cardiac hypothyroidism due to upregulation of type\u20093 iodothyronine deiodinase. Thyroid hormones improve several pathophysiological mechanisms of HFpEF, including diastolic dysfunction and extra-cardiac abnormalities. Supplementation with thyroid hormones (levothyroxine and\/or liothyronine), modulation of deiodinase activity, and heart-specific thyroid receptor agonists are potential therapeutic approaches for the treatment of HFpEF. Further preclinical and clinical studies are needed to clarify the role of thyroid hormones in the treatment of HFpEF. <\/jats:p>","DOI":"10.1177\/2042018820958331","type":"journal-article","created":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T06:04:41Z","timestamp":1601877881000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["Thyroid hormones and modulation of diastolic function: a promising target for heart failure with preserved ejection fraction"],"prefix":"10.1177","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8173-8255","authenticated-orcid":false,"given":"Jo\u00e3o S\u00e9rgio","family":"Neves","sequence":"first","affiliation":[{"name":"Departamento de Cirurgia e Fisiologia, Unidade de Investiga\u00e7\u00e3o Cardiovascular, Faculdade de Medicina, Universidade do Porto, Porto, Portugal"},{"name":"Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar 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Porto, Portugal"}]},{"given":"Ana Rita","family":"Leite","sequence":"additional","affiliation":[{"name":"Departamento de Cirurgia e Fisiologia, Unidade de Investiga\u00e7\u00e3o Cardiovascular, Faculdade de Medicina, Universidade do Porto, Porto, Portugal"}]},{"given":"Jo\u00e3o","family":"Almeida-Coelho","sequence":"additional","affiliation":[{"name":"Departamento de Cirurgia e Fisiologia, Unidade de Investiga\u00e7\u00e3o Cardiovascular, Faculdade de Medicina, Universidade do Porto, Porto, Portugal"}]},{"given":"Andr\u00e9","family":"Louren\u00e7o","sequence":"additional","affiliation":[{"name":"Departamento de Cirurgia e Fisiologia, Unidade de Investiga\u00e7\u00e3o Cardiovascular, Faculdade de Medicina, Universidade do Porto, Porto, Portugal"}]},{"given":"In\u00eas","family":"Falc\u00e3o-Pires","sequence":"additional","affiliation":[{"name":"Departamento de Cirurgia e Fisiologia, Unidade de Investiga\u00e7\u00e3o Cardiovascular, Faculdade de Medicina, Universidade do Porto, Porto, Portugal"}]},{"given":"Davide","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, Faculdade de Medicina, Universidade do Porto, Porto, Portugal"},{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade da Universidade do Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7808-3596","authenticated-orcid":false,"given":"Adelino","family":"Leite-Moreira","sequence":"additional","affiliation":[{"name":"Departamento de Cirurgia e Fisiologia, Unidade de Investiga\u00e7\u00e3o Cardiovascular, Faculdade de Medicina, Universidade do Porto, Alameda Hern\u00e2ni Monteiro, Porto, 4200-319, 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