{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T17:06:06Z","timestamp":1765040766478},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["UEG Journal"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Endoscopic submucosal dissection (ESD) enables accurate pathological evaluation and low recurrence rates. Large series describing ESD outcomes in Western countries are scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the real\u2010life experience of ESD in a single Western centre.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data of all the patients submitted to ESD in our centre were prospectively recorded in a database, from the first procedure in 2011 until May 2017. Feasibility, en bloc and R0 resection rates and safety were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three hundred and one ESDs were performed (37 in submucosal lesions) on 283 patients (54% male). Lesions were located in the oesophagus (<jats:italic>n<\/jats:italic>\u2009=\u200913), stomach (<jats:italic>n<\/jats:italic>\u2009=\u2009169), duodenum (<jats:italic>n<\/jats:italic>\u2009=\u20094), colon (<jats:italic>n<\/jats:italic>\u2009=\u200935) and rectum (<jats:italic>n<\/jats:italic>\u2009=\u200980). ESD was technically successful in 292 lesions (97%); among malignant or premalignant epithelial lesions (<jats:italic>n<\/jats:italic>\u2009=\u2009232), the en bloc resection rate was 91% and, of those, the R0 resection rate was 87% (between 69% in the colon and 93% in the stomach). Two patients needed surgery due to adverse events. Surgery for non\u2010curative ESD was performed in 12 cases (58% without residual lesion). There were 10 perforations, 9 of them closed endoscopically. Mortality was 0%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our real\u2010life experience shows that ESD is feasible, safe and effective in Western settings.<\/jats:p><\/jats:sec>","DOI":"10.1177\/2050640618755237","type":"journal-article","created":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T14:56:28Z","timestamp":1516805788000},"page":"702-709","update-policy":"http:\/\/dx.doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Real\u2010life evaluation of the safety, efficacy and therapeutic outcomes of endoscopic submucosal dissection in a Western tertiary centre"],"prefix":"10.1002","volume":"6","author":[{"given":"Jo\u00e3o","family":"Santos-Antunes","sequence":"first","affiliation":[{"name":"Gastroenterology Department Centro Hospitalar S. Jo\u00e3o Porto Portugal"}]},{"given":"Francisco","family":"Baldaque-Silva","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Centro Hospitalar S. Jo\u00e3o Porto Portugal"},{"name":"Department of upper GI Diseases Unit of Gastrointestinal Endoscopy Karolinska University Hospital Stockholm Sweden"}]},{"given":"Margarida","family":"Marques","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Centro Hospitalar S. Jo\u00e3o Porto Portugal"}]},{"given":"Joanne","family":"Lopes","sequence":"additional","affiliation":[{"name":"Pathology Department Centro Hospitalar S. Jo\u00e3o Porto Portugal"}]},{"given":"F\u00e1tima","family":"Carneiro","sequence":"additional","affiliation":[{"name":"Pathology Department Centro Hospitalar S. Jo\u00e3o Porto Portugal"},{"name":"Ipatimup\/i3S (Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade da Universidade do Porto) Porto Portugal"}]},{"given":"Guilherme","family":"Macedo","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Centro Hospitalar S. 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