{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T16:33:45Z","timestamp":1764002025170,"version":"3.41.2"},"reference-count":21,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery Open Reports"],"published-print":{"date-parts":[[2015,7,1]]},"abstract":"<jats:p> Case summary We report a clinical case of blepharitis due to Cryptococcus neoformans yeasts in a 2-year-old stray cat from northern Portugal (Vila Real) without concurrent naso-ocular signs. Ophthalmological examination revealed mucopurulent discharge from an open wound in the right upper and lower lids. Slit-lamp biomicroscopy showed a normal anterior segment, and intraocular pressure was within the normal reference interval. No fundoscopic alterations were detected in either eye by direct and indirect ophthalmoscopic examination. Cytological examination of an appositional smear showed numerous polymorphic neutrophils and macrophages, together with spherical yeast cells compatible with Cryptococcus species. Molecular analysis by means of PCR and restriction fragment length polymorphism identified C neoformans genotype VNI. The cat was treated with itraconazole, and amoxicillin and clavulanic acid, combined with a commercial ear ointment and an imidacloprid\/moxidectin spot-on application for bilateral parasitic otitis caused by Otodectes cynotis. One month after treatment, the clinical signs were completely resolved. Localised cutaneous lesions, as in the present case, probably result from contamination of cat-scratch injuries with viable encapsulated yeasts. <\/jats:p><jats:p> Relevance and novel information This is, to the best of our knowledge, the first clinical report of feline blepharitis due to C neoformans without concurrent naso-ocular signs. The current findings, together with those from recent reports of the infection in domestic animals, should alert the veterinary community both in Portugal and in Europe to this underdiagnosed disease. <\/jats:p>","DOI":"10.1177\/2055116915593963","type":"journal-article","created":{"date-parts":[[2015,7,7]],"date-time":"2015-07-07T01:40:41Z","timestamp":1436233241000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Blepharitis due to <i>Cryptococcus neoformans<\/i> in a cat from northern Portugal"],"prefix":"10.1177","volume":"1","author":[{"given":"Paulo","family":"Pimenta","sequence":"first","affiliation":[{"name":"Hospital Veterin\u00e1rio de Tr\u00e1s-os-Montes, Vila Real, Portugal"}]},{"given":"Sofia","family":"Alves-Pimenta","sequence":"additional","affiliation":[{"name":"Hospital Veterin\u00e1rio de Tr\u00e1s-os-Montes, Vila Real, Portugal"}]},{"given":"Jo\u00e3o","family":"Barros","sequence":"additional","affiliation":[{"name":"Hospital Veterin\u00e1rio de Tr\u00e1s-os-Montes, Vila Real, Portugal"}]},{"given":"Maria J","family":"Pereira","sequence":"additional","affiliation":[{"name":"Hospital Veterin\u00e1rio de Tr\u00e1s-os-Montes, Vila Real, Portugal"}]},{"given":"Lu\u00eds","family":"Maltez","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, School of Agrarian and Veterinary Sciences, University of Tr\u00e1s-os-Montes e Alto Douro, Vila Real, Portugal"}]},{"given":"A Paula","family":"Maduro","sequence":"additional","affiliation":[{"name":"Mycology Group, Medical Microbiology Unit, Global Health and Tropical Medicine, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisbon, Portugal"}]},{"given":"Lu\u00eds","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, School of Agrarian and Veterinary Sciences, University of Tr\u00e1s-os-Montes e Alto Douro, Vila Real, Portugal"}]},{"given":"Ana C","family":"Coelho","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, School of Agrarian and Veterinary Sciences, University of Tr\u00e1s-os-Montes e Alto Douro, Vila Real, Portugal"},{"name":"Animal and Veterinary Research Centre, University of Tr\u00e1s-os-Montes e Alto Douro, Vila Real, Portugal"}]}],"member":"179","published-online":{"date-parts":[[2015,7,6]]},"reference":[{"key":"bibr1-2055116915593963","first-page":"621","volume-title":"Infectious diseases of the dog and cat","author":"Sykes 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