{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T15:24:44Z","timestamp":1772551484313,"version":"3.50.1"},"reference-count":34,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Novartis Pharma AG, Basel, Switzerland"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis Journal \u2013 Experimental, Translational and Clinical"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Multiple sclerosis (MS) places a considerable financial burden on the society. However, data quantifying the contemporary cost burden in France are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This cost-of-illness study aimed to estimate the direct and indirect costs associated with MS in France.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Between October 2020-November 2020, 208 French adults with a confirmed diagnosis of MS were recruited via MSCopilot\n                      <jats:sup>\u00ae<\/jats:sup>\n                      (a new MS self-assessment digital solution) and several MS patient networks. Indirect costs were estimated using a combination of top-down and bottom-up approaches. Direct costs were retrieved from Assurance Maladie (i.e. national system of health insurance) publications. Out-of-pocket expenses (OOPEs) incurred by MS patients were also reported. All costs were expressed in \u20ac2020. Data from the survey were extrapolated to the overall French MS population.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>MS exerted an annual cost burden of \u20ac2.7 billion on the French society (indirect costs: \u20ac1.3 billion; direct costs: \u20ac1.4 billion). Mean annual costs were \u20ac27,164.7 per-patient, with indirect and direct costs accounting for 48.1% and 51.9% of the total annual costs, respectively. OOPEs contributed over \u20ac90 million to the total annual costs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MS imposes a substantial cost burden on the French society, with approximately half of the total annual costs driven by indirect costs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20552173221093219","type":"journal-article","created":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T02:40:45Z","timestamp":1650595245000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["The socioeconomic impact of multiple sclerosis in France: Results from the PETALS study"],"prefix":"10.1177","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7668-8767","authenticated-orcid":false,"given":"A","family":"Bouleau","sequence":"first","affiliation":[{"name":"Aster\u00e8s Inc., Paris, France"},{"name":"Ad Scientiam, Paris, France"}]},{"given":"C","family":"Dulong","sequence":"additional","affiliation":[{"name":"Ad Scientiam, Paris, France"},{"name":"Ad Scientiam, Paris, France"}]},{"given":"CA","family":"Schwerer","sequence":"additional","affiliation":[{"name":"Aster\u00e8s Inc., Paris, France"},{"name":"Ad Scientiam, Paris, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0627-5155","authenticated-orcid":false,"given":"R","family":"Delgrange","sequence":"additional","affiliation":[{"name":"Ad Scientiam, Paris, France"}]},{"given":"K","family":"Bouaou","sequence":"additional","affiliation":[{"name":"Ad Scientiam, Paris, France"}]},{"given":"T","family":"Brochu","sequence":"additional","affiliation":[{"name":"Ad Scientiam, Paris, France"}]},{"given":"S","family":"Zinai","sequence":"additional","affiliation":[{"name":"Ad Scientiam, Paris, France"}]},{"given":"K","family":"\u0160vecov\u00e1","sequence":"additional","affiliation":[{"name":"Independent HEOR Consultant, Zurich, Switzerland"}]},{"given":"MJ","family":"S\u00e1","sequence":"additional","affiliation":[{"name":"Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o and Universidade Fernando Pessoa, Porto, Portugal"}]},{"given":"A","family":"Petropoulos","sequence":"additional","affiliation":[{"name":"Novartis Hellas SACI, Athens, Greece"},{"name":"Novartis Pharma AG"}]},{"given":"S","family":"Aly","sequence":"additional","affiliation":[{"name":"Novartis Pharma AG"}]},{"given":"P","family":"Labauge","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Neurologie, Centre Hospitalier Universitaire de Montpellier, Montpellier, France"}]}],"member":"179","published-online":{"date-parts":[[2022,4,21]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13819"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30925-9"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-017-8513-0"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458509102771"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2019.101396"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458512441566"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.1466"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2019.01.049"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0159129"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2020.102162"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2014.02.007"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458517708125"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14091"},{"key":"e_1_3_3_15_2","unstructured":"Assurance Maladie. 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