{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:36:51Z","timestamp":1792787811672,"version":"4.5.0"},"reference-count":35,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Canadian Institutes of Health Research","id":[{"id":"https:\/\/ror.org\/01gavpb45","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cannabis &amp; Cannabinoid Research"],"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>While recreational marijuana remains illegal under federal law in the United States, \u201chemp-derived\u201d products that contain less than \u2264 0.3% Delta-9-tetrahydrocannabinol (THC) were legalized in 2018. New classes of intoxicating products have proliferated, such as Delta-8 products, with few regulatory restrictions. The current study sought to assess awareness and prevalence of use of Delta-8-THC products in the United States.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Data are from 69,564 U.S. 16\u201365-year-old respondents to the 2021\u20132022 International Cannabis Policy Study (ICPS). Participants were asked about awareness, ever use, and past-month use of specific THC isomers. Logistic regression models examined correlates in the awareness and use of Delta-8-THC, including state cannabis laws.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In 2021, 14.5% of respondents reported \u2018hearing\u2019 about Delta-8 products, which increased to 21.8% in 2022 (AOR = 1.76, 95% CI = 1.59\u20131.95,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001). Ever use of Delta-8 was higher in states where \u2018conventional\u2019 Delta-9 cannabis was illegal (11.2%), compared with states where medical cannabis (8.5% vs. 11.2%, AOR = 0.68, 95% CI = 0.58\u20130.79,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001) and adult-use recreational cannabis is legal (6.5% vs. 11.2%, AOR = 0.44, 95% CI = 0.36\u20130.55,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>The cannabinoid market is rapidly diversifying with increased use of hemp-derived cannabinoid products, particularly in states where Delta-9-THC cannabis remains illegal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>There is an urgent need for enhanced monitoring of the diversifying cannabinoid market. Education is warranted to inform consumers about the type and potential health risks of novel hemp-derived products.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/25785125261492385","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:40:50Z","timestamp":1791387650000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Awareness and Use of Delta-8-THC Cannabis Products in the United States: Findings from National Surveys in 2021 and 2022"],"prefix":"10.1177","author":[{"given":"Gillian","family":"Schauer","sequence":"first","affiliation":[{"name":"Cannabis Regulators Association (CANNRA), Lexington, Kentucky, USA."},{"name":"Addictions, Drug &amp; Alcohol Institute, University of Washington, Seattle, Washington, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0085-2206","authenticated-orcid":false,"given":"Maryam","family":"Iraniparast","sequence":"additional","affiliation":[{"name":"School of Public Health Sciences, University of Waterloo, Waterloo, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8197-6010","authenticated-orcid":false,"given":"David","family":"Hammond","sequence":"additional","affiliation":[{"name":"School of Public Health Sciences, University of Waterloo, Waterloo, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-45541-9_1"},{"key":"e_1_3_3_3_1","unstructured":"2.115th U.S. Congress. H.R. 2\u2014Agriculture Improvement Act of 2018. 2018. Available from: https:\/\/www.congress.gov\/bill\/115th-congress\/house-bill\/2 [Last accessed: December27 2018]."},{"key":"e_1_3_3_4_1","unstructured":"3.Brightfield Group. The Rise of Hemp-Derived THC: Consumer Trends and Market Insights. 2024. Available from: https:\/\/blog.brightfieldgroup.com\/the-rise-of-hemp-derived-thc-products [Last accessed: February24 2025]."},{"key":"e_1_3_3_5_1","unstructured":"4.U.S. Food and Drug Administration. Cannabis Products and the Potential Impact on Patients. 2024. Available from: https:\/\/www.youtube.com\/watch?v=76awXuwxNE0 [Last accessed: February24 2025]."},{"key":"e_1_3_3_6_1","volume-title":"Critical Review: Isomers of THC","author":"WHO Expert Committee on Drug Dependence","year":"2018","unstructured":"5.WHO Expert Committee on Drug Dependence. Critical Review: Isomers of THC. WHO; 2018."},{"key":"e_1_3_3_7_1","first-page":"161","article-title":"Isolation of two new cannabinoid acids from Cannabis sativa L. of Czechoslovak origin","volume":"74","author":"Hanus L","year":"1975","unstructured":"6.Hanus L, , Krejci Z. Isolation of two new cannabinoid acids from Cannabis sativa L. of Czechoslovak origin. Acta Univ Palacki Olomuc Fac Med 1975;74:161\u2013166.","journal-title":"Acta Univ Palacki Olomuc Fac Med"},{"key":"e_1_3_3_8_1","unstructured":"7.Attorney General Letter to Congress on the Five-Year Reauthorization of the Farm Bill. 2024. Available from: https:\/\/ag.hawaii.gov\/wp-content\/uploads\/2024\/03\/Corrected-Ltr-Concerning-Five-Year-Farm-Bill-Reauthorization.pdf [Last accessed: February24 2025]."},{"key":"e_1_3_3_9_1","unstructured":"8.Schauer GL. Written testimony delivered before the house committee on oversight and accountability health care and financial services subcommittee for a hearing on \u201cHemp in the Modern World: The Yearslong Wait for FDA Action\u201d. 2023. Available from: https:\/\/oversight.house.gov\/wp-content\/uploads\/2023\/07\/CANNRA-Written-Testimony_07-2023_Final.pdf [Last accessed: July15 2024]."},{"key":"e_1_3_3_10_1","unstructured":"9.U.S. Food and Drug Administration. FDA FTC Continue Joint Effort to Protect Consumers Against Companies Illegally Selling Copycat Delta-8 THC Food Products. FDA; 2024. Available from: https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-ftc-continue-joint-effort-protect-consumers-against-companies-illegally-selling-copycat-delta-8 [Last accessed: February24 2025]."},{"key":"e_1_3_3_11_1","unstructured":"10.U.S. Food and Drug Administration. FDA FTC warn of risks to children from copycat food products containing delta-8 THC. AAP News; 2024. Available from: https:\/\/www.fda.gov\/media\/182538\/download#:\u223c:text=Concerns%20related%20to%20delta%2D8%20THC%20and%20children&text=31%2C%202023%2C%20the%20FDA%20received confusion%20and%20loss%20of%20consciousness [Last accessed: February24 2025]."},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/15563650.2024.2340115"},{"key":"e_1_3_3_13_1","unstructured":"12.U.S. Food and Drug Administration. 5 Things to Know about Delta-8 Tetrahydrocannabinol\u2014Delta-8 THC. FDA; 2022. Available from: https:\/\/www.fda.gov\/consumers\/consumer-updates\/5-things-know-about-delta-8-tetrahydrocannabinol-delta-8-thc [Last accessed: August16 2023]."},{"key":"e_1_3_3_14_1","unstructured":"13.West Virginia Poison Center. West Virginia Poison Center Substance Abuse Alert #WV003: Reported Cases of Adverse Reactions to Delta-8 THC Products in West Virginia. West Virginia Poison Center; 2021."},{"key":"e_1_3_3_15_1","volume-title":"Emerging Public Health Concern: Delta-8","author":"Michigan Poison Center","year":"2021","unstructured":"14.Michigan Poison Center. Emerging Public Health Concern: Delta-8. Michigan Poison Center; 2021."},{"key":"e_1_3_3_16_1","unstructured":"15.Marijuana Policy Project. What are state regulators doing? 2023. Available from: https:\/\/www.mpp.org\/policy\/federal\/delta-8\/what-are-state-regulators-doing\/ [Last accessed: July1 2025]."},{"key":"e_1_3_3_17_1","unstructured":"16.Brosnan M. Six States Pass Hemp Laws; More Wait in the Wings. CRB Monitor; 2024. Available from: https:\/\/news.crbmonitor.com\/2024\/05\/6-states-pass-hemp-laws-more-wait-in-the-wings\/#:\u223c:text=Already%20this%20year%2C%20six%20states on%20the%20manufacturers%20and%20retailers [Last accessed: July1 2025]."},{"key":"e_1_3_3_18_1","unstructured":"17.National Agricultural Law Center. Legal Challenges to State Hemp Laws and Regulations. 2023. Available from: https:\/\/nationalaglawcenter.org\/legal-challenges-to-state-hemp-laws-and-regulations\/ [Last accessed: July1 2025]."},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42238-021-00115-8"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2022.107374"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.0865"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1089\/can.2021.0124"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.47373"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2025.108026"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2020.102698"},{"key":"e_1_3_3_26_1","volume-title":"Standard Definitions: Final Dispositions of Case Codes and Outcome Rates for Surveys (8th ed.). American Association for Public Opinion Research","author":"Smith TW","year":"2015","unstructured":"25.Smith TW, , Bailar B, , Couper M. Standard Definitions: Final Dispositions of Case Codes and Outcome Rates for Surveys (8th ed.). American Association for Public Opinion Research. AAPOR: Oakbrook Terrace; 2015."},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/dar.13664"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2019.07.004"},{"key":"e_1_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.1037\/hea0000534"},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsad.25-00034"},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.15844\/pedneurbriefs-32-3"},{"key":"e_1_3_3_32_1","unstructured":"31.Sparr-Jaswa A. Potency and purity concerns in unregulated hemp products: A rapid review to inform public safety. Thomas Jefferson University; 2024. Available from: https:\/\/jdc.jefferson.edu\/mphcapstone_presentation\/566\/#:\u223c:text=Results%20showed%20that%20many%20hemp in%20many%20of%20the%20products [Last accessed: August14 2025]."},{"key":"e_1_3_3_33_1","unstructured":"32.Johnson L. Lab study: Over 50% of hemp delta-9 products are mislabeled and get you higher than cannabis. CBD Oracle; 2022. Available from: https:\/\/cbdoracle.com\/news\/hemp-delta-9-thc-products-lab-study-consumer-safety-and-legality\/ [Last accessed: August14 2025]."},{"key":"e_1_3_3_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2022.103716"},{"key":"e_1_3_3_35_1","unstructured":"34.King S. How Some THC is Legal - For Now. Rolling Stone; 2021. Available from: https:\/\/www.rollingstone.com\/culture\/culture-features\/delta-8-thc-legal-weed-explained-1113859\/ [Last accessed: February25 2021]."},{"key":"e_1_3_3_36_1","volume-title":"This Drug Gets You High, and Is Legal (Maybe) Across the Country","author":"Richtel M","year":"2021","unstructured":"35.Richtel M. This Drug Gets You High, and Is Legal (Maybe) Across the Country. 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