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Here, we demonstrate that natural killer (NK) cells and CD8+ T cells recognize Necl-2 through a receptor known as class I-restricted T-cell\u2013associated molecule (CRTAM), which is expressed only on activated cells. CRTAM\u2013Necl-2 interactions promote cytotoxicity of NK cells and interferon \u03b3 (IFN-\u03b3) secretion of CD8+ T cells in vitro as well as NK cell\u2013mediated rejection of tumors expressing Necl-2 in vivo. These results provide evidence for an additional mechanism of tumor suppression mediated by TSLC1 that involves cytotoxic lymphocytes. Furthermore, they reveal Necl-2 as one of the molecular targets that allows the immunosurveillance network to distinguish tumor cells from normal cells.<\/jats:p>","DOI":"10.1182\/blood-2005-02-0817","type":"journal-article","created":{"date-parts":[[2005,4,6]],"date-time":"2005-04-06T13:33:45Z","timestamp":1112794425000},"page":"779-786","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":172,"title":["The tumor suppressor TSLC1\/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM"],"prefix":"10.1182","volume":"106","author":[{"given":"Kent S.","family":"Boles","sequence":"first","affiliation":[{"name":"From the Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO; and the Department of Pediatrics, Washington University School of Medicine, St Louis, MO."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Winfried","family":"Barchet","sequence":"additional","affiliation":[{"name":"From the Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO; and the Department of Pediatrics, Washington University School of Medicine, St Louis, MO."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Diacovo","sequence":"additional","affiliation":[{"name":"From the Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO; and the Department of Pediatrics, Washington University School of Medicine, St Louis, MO."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Cella","sequence":"additional","affiliation":[{"name":"From the Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO; and the Department of Pediatrics, Washington University School of Medicine, St Louis, MO."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Colonna","sequence":"additional","affiliation":[{"name":"From the Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO; and the Department of Pediatrics, Washington University School of Medicine, St Louis, MO."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"234","reference":[{"key":"2020021223274524500_REF1","doi-asserted-by":"crossref","unstructured":"Dunn GP, Old LJ, Schreiber RD. 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