{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:50:41Z","timestamp":1790988641803,"version":"4.1.0"},"reference-count":191,"publisher":"American Society of Hematology","issue":"1","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2001,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This review addresses the biology and the treatment of lymphomas arising from mucosa-associated lymphoid tissue (MALT). This entity, first described in 1983, represents about 8% of all non-Hodgkin's lymphomas and was recently re-classified as \u201cextranodal marginal zone lymphomas of MALT-type.\u201d The term marginal zone lymphoma (MZL) encompasses the three closely related lymphoma subtypes of nodal, primary splenic and extranodal lymphomas of MALT type: the latter represent the vast majority of MZL. These lymphomas arise at different anatomic sites, are composed of mature B-cells lacking expression of CD5 and CD10, often present with overlapping morphologic features, but typically quite distinct clinical behaviors. Only very recently cytogenetic\/molecular genetic observations have underlined the distinctiveness of these three lymphoid neoplasms, which in both the R.E.A.L. and WHO-classifications are included in the general term of MZL. MALT lymphomas arise in numerous extranodal sites, but gastric MALT lymphoma is the most common and best studied and is, therefore, the paradigm for the group as a whole.<\/jats:p><jats:p>Dr. Isaacson describes the principal histological features of these lymphomas, including criteria to distinguish this entity from other small B-cell lymphomas. Several lines of evidence suggest that gastric lymphoma arises from MALT acquired as the result of aH. pyloriinfection. However, at least 1\/3 of cases do not respond to eradication ofH. pylori. Very recent data suggest that both t(11;18) (q21;q21) and bcl10 nuclear expression are associated with failure to respond to this treatment.<\/jats:p><jats:p>Dr. Gascoyne discusses the biologic function of proteins deregulated through the different translocations, which play a role in pathogenesis of MALT lymphomas, emphasizing particularly their influence in disrupting the apoptotic pathway.<\/jats:p><jats:p>Dr. Zucca reviews findings suggesting that MALT lymphoma is an antigen driven neoplasm. He also presents specific guidelines for treatment of gastric lymphomas trying to shed some light on the amazingly inconsistent and confusing data in the literature.<\/jats:p><jats:p>Taking advantage on the more than 300 non-gastric MALT lymphomas collected by the International Extranodal Lymphoma Study Group (ILESG), Dr. Cavalli compares gastric lymphomas with those arising in many other sites.<\/jats:p><jats:p>Overall, the data presented in this session will underline the fact, that MALT lymphomas are characterized by some unique biological properties.<\/jats:p>","DOI":"10.1182\/asheducation-2001.1.241","type":"journal-article","created":{"date-parts":[[2003,8,28]],"date-time":"2003-08-28T00:29:50Z","timestamp":1062030590000},"page":"241-258","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":109,"title":["MALT Lymphomas"],"prefix":"10.1182","volume":"2001","author":[{"given":"Franco","family":"Cavalli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter G.","family":"Isaacson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randy D.","family":"Gascoyne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Zucca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"key":"2020021223412894800_R1","doi-asserted-by":"crossref","unstructured":"Isaacson P, Wright DH. Malignant lymphoma of mucosa-associated lymphoid tissue. A distinctive type of B-cell lymphoma. Cancer.1983;52:1410\u20131416.","DOI":"10.1002\/1097-0142(19831015)52:8<1410::AID-CNCR2820520813>3.0.CO;2-3"},{"key":"2020021223412894800_R2","doi-asserted-by":"crossref","unstructured":"Isaacson P, Wright DH. Extranodal malignant lymphoma arising from mucosa associated lymphoid tissue. Cancer.1984;53:2515\u20132524.","DOI":"10.1002\/1097-0142(19840601)53:11<2515::AID-CNCR2820531125>3.0.CO;2-C"},{"key":"2020021223412894800_R3","doi-asserted-by":"crossref","unstructured":"Spencer J, Finn, T, Isaacson PG. Human Peyer's patches: an immunohistochemical study. Gut.1986;27:405\u2013410.","DOI":"10.1136\/gut.27.4.405"},{"key":"2020021223412894800_R4","unstructured":"Spencer J, Finn T, Pulford KAF et al. The human gut contains a novel population of B-lymphocytes which resemble marginal zone cells. Clin Exp Immunol.1985;62:607\u2013610."},{"key":"2020021223412894800_R5","unstructured":"Harris NL, Jaffe ES, Diebold J et al. The World Health Organization classification of neoplastic diseases of haematopoietic and lymphoid tissues: report of the Clinical Advisory Committee Meeting, Airlie House, Virginia, November 1997"},{"key":"2020021223412894800_R6","unstructured":"Isaacson PG, Norton AJ. Extranodal Lymphomas. New York: Churchill Livingstone; 1994."},{"key":"2020021223412894800_R7","doi-asserted-by":"crossref","unstructured":"Isaacson PG, Spencer J. Malignant lymphoma of mucosa-associated lymphoid tissue. Histopathology.1987;11:445\u2013462.","DOI":"10.1111\/j.1365-2559.1987.tb02654.x"},{"key":"2020021223412894800_R8","doi-asserted-by":"crossref","unstructured":"Isaacson PG, Wotherspoon AC, Diss T et al. Follicular colonization in B-cell lymphoma of mucosa-associated lymphoid tissue. 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Clonal origin of micro-lymphomas in low grade B-cell gastric MALT lymphoma. J Pathol.1997;181:57(Abstract)"},{"key":"2020021223412894800_R13","doi-asserted-by":"crossref","unstructured":"Du MQ, Diss TC, Dogan A, et al. Clone specific PCR reveals wide dissemination of gastric malt lymphoma to the gastrointestinal mucosa. J Pathol. 12000;192:488\u2013493.","DOI":"10.1002\/1096-9896(2000)9999:9999<::AID-PATH727>3.0.CO;2-J"},{"key":"2020021223412894800_R14","doi-asserted-by":"crossref","unstructured":"Du MQ, Peng HZ, Dogan A, et al. Preferential dissemination of B-cell gastric mucosa-associated lymphoid tissue (MALT) lymphoma to the splenic marginal zone. Blood.1997;90:4071\u20134077.","DOI":"10.1182\/blood.V90.10.4071"},{"key":"2020021223412894800_R15","unstructured":"Dogan A, Du M, Koulis A et al. Expression of lymphocyte homing receptors and vascular addressins in low-grade gastric B-cell lymphomas of mucosa- associated lymphoid tissue. 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