{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:24:06Z","timestamp":1791397446082,"version":"4.3.3"},"reference-count":51,"publisher":"American Society of Hematology","issue":"1","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2006,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Peripheral T-cell lymphomas (PTLs) are uncommon, accounting for fewer than 10% of all non-Hodgkin lymphomas. Success in therapy of the PTLs has lagged behind that of aggressive B-cell lymphomas, and most PTLs have a poor prognosis. The molecular pathogenesis of most PTLs is also poorly understood. In the WHO classification, clinical features, in conjunction with morphological and immunophenotypic criteria, are relied on to define most disease entities.<\/jats:p><jats:p>Functionally, T-cell lymphomas are related to the two major arms of the immune system, the innate and adaptive immune systems. NK cells and T cells of the innate immune system recognize antigen in the absence of MHC antigens and are involved in mucosal immunity. The lymphomas derived from these cells often involve cutaneous and mucosal sites. The expression of cytotoxic molecules in these lymphomas may predispose to apoptosis by tumor cells and normal bystander cells. Hepatosplenic T-cell lymphoma is a systemic disease derived from functionally immature innate effector cells, most often of \u03b3\u03b4 T-cell origin. In contrast, most nodal T-cell lymphomas belong to the adaptive immune system.<\/jats:p><jats:p>Angioimmunoblastic T-cell lymphoma (AILT) is mostly likely derived from follicular helper T-cells (TFH), a finding that explains many of its pathological and clinical features. Studies of these neoplasms may assist in further unraveling the functional diversity of their normal counterparts.<\/jats:p>","DOI":"10.1182\/asheducation-2006.1.317","type":"journal-article","created":{"date-parts":[[2006,11,22]],"date-time":"2006-11-22T23:14:02Z","timestamp":1164237242000},"page":"317-322","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":66,"title":["Pathobiology of Peripheral T-cell Lymphomas"],"prefix":"10.1182","volume":"2006","author":[{"given":"Elaine S.","family":"Jaffe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"key":"2019111703450752100_R1","unstructured":"Jaffe ES, Harris NL, Stein H, Vardiman J. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues. Lyon, France: IARC Press; 2001."},{"key":"2019111703450752100_R2","doi-asserted-by":"crossref","unstructured":"Savage KJ, Chhanabhai M, Gascoyne RD, Connors JM. Characterization of peripheral T-cell lymphomas in a single North American institution by the WHO classification. Ann Oncol. 2004;15:1467\u20131475.","DOI":"10.1093\/annonc\/mdh392"},{"key":"2019111703450752100_R3","doi-asserted-by":"crossref","unstructured":"Nava VE, Jaffe ES. The pathology of NK-cell lymphomas and leukemias. Adv Anat Pathol. 2005;12:27\u201334.","DOI":"10.1097\/01.pap.0000151318.34752.80"},{"key":"2019111703450752100_R4","unstructured":"Elenitoba-Johnson KSJ, Zarate-Osorno A, Meneses A, et al. Cytotoxic granular protein expression, Epstein-Barr virus strain type, and latent membrane protein-1 oncogene deletions in nasal T-lymphocyte\/natural killer cell lymphomas from Mexico. Mod Pathol. 1998;11:754\u2013761."},{"key":"2019111703450752100_R5","doi-asserted-by":"crossref","unstructured":"Quintanilla-Martinez L, Kumar S, Fend F, et al. Fulminant EBV(+) T-cell lymphoproliferative disorder following acute\/ chronic EBV infection: a distinct clinicopathologic syndrome. Blood. 2000;96:443\u2013451.","DOI":"10.1182\/blood.V96.2.443"},{"key":"2019111703450752100_R6","doi-asserted-by":"crossref","unstructured":"Kimura H, Hoshino Y, Kanegane H, et al. Clinical and virologic characteristics of chronic active Epstein-Barr virus infection. Blood. 2001;98:280\u2013286.","DOI":"10.1182\/blood.V98.2.280"},{"key":"2019111703450752100_R7","doi-asserted-by":"crossref","unstructured":"Zhang Y, Nagata H, Ikeuchi T, et al. Common cytological and cytogenetic features of Epstein-Barr virus (EBV)-positive natural killer (NK) cells and cell lines derived from patients with nasal T\/NK-cell lymphomas, chronic active EBV infection and hydroa vacciniforme-like eruptions. Br J Haematol. 2003;121:805\u2013814.","DOI":"10.1046\/j.1365-2141.2003.04359.x"},{"key":"2019111703450752100_R8","doi-asserted-by":"crossref","unstructured":"Navarro JT, Ribera JM, Mate JL, et al. Hepatosplenic T-gammadelta lymphoma in a patient with Crohn\u2019s disease treated with azathioprine. Leuk Lymphoma. 2003;44:531\u2013533.","DOI":"10.1080\/1042819021000035662"},{"key":"2019111703450752100_R9","doi-asserted-by":"crossref","unstructured":"Gardner RV, Velez MC, Ode DL, Lee JW, Correa H. Gamma\/ delta T-cell lymphoma as a recurrent complication after transplantation. Leuk Lymphoma. 2004;45:2355\u20132359.","DOI":"10.1080\/10428190412331283215"},{"key":"2019111703450752100_R10","doi-asserted-by":"crossref","unstructured":"Belhadj K, Reyes F, Farcet JP, et al. Hepatosplenic {gamma}{delta} T-cell lymphoma is a rare clinicopathologic entity with poor outcome: report on a series of 21 patients. 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