{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T11:59:33Z","timestamp":1648987173836},"reference-count":18,"publisher":"American Society of Hematology","issue":"1","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2008,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A 58-year-old woman presents with a recent diagnosis of peripheral T-cell lymphoma, unspecified. She has read through Google\u00ae that the \u201cbest treatment\u201d for this disorder is stem cell transplantation\u2014she asks you if you recommend this treatment?<\/jats:p>","DOI":"10.1182\/asheducation-2008.1.39","type":"journal-article","created":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T15:12:58Z","timestamp":1229008378000},"page":"39-41","update-policy":"http:\/\/dx.doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":5,"title":["Does High-Dose Therapy and Autologous Hematopoietic Stem Cell Transplantation Have a Role in the Primary Treatment of Peripheral T-Cell Lymphomas?"],"prefix":"10.1182","volume":"2008","author":[{"given":"Andrei R.","family":"Shustov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerry J.","family":"Savage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"234","reference":[{"key":"2019111709593716000_R1","unstructured":"Gisselbrecht C, Gaulard P, Lepage E, et al. Prognostic significance of T-cell phenotype in aggressive non-Hodgkin\u2019s lymphomas. Groupe d\u2019Etudes des Lymphomes de l\u2019Adulte (GELA). Blood. 1998;92:76\u201382."},{"key":"2019111709593716000_R2","doi-asserted-by":"crossref","unstructured":"Melnyk A, Rodriguez A, Pugh WC, Cabannillas F. Evaluation of the Revised European-American Lymphoma classification confirms the clinical relevance of immunophenotype in 560 cases of aggressive non-Hodgkin\u2019s lymphoma. Blood. 1997;89:4514\u20134520.","DOI":"10.1182\/blood.V89.12.4514"},{"key":"2019111709593716000_R3","unstructured":"Lopez-Guillermo A, Cid J, Salar A, et al. Peripheral T-cell lymphomas: initial features, natural history, and prognostic factors in a series of 174 patients diagnosed according to the R.E.A.L. Classification. Ann Oncol. 1998;9:849\u2013855."},{"key":"2019111709593716000_R4","doi-asserted-by":"crossref","unstructured":"Savage KJ, Chhanabhai M, Gascoyne RD, Connors JM. Characterization of peripheral T-cell lymphomas in a single North American institution by the WHO classification. Ann Oncol. 2004;15:1467\u20131475.","DOI":"10.1093\/annonc\/mdh392"},{"key":"2019111709593716000_R5","doi-asserted-by":"crossref","unstructured":"Gascoyne RD, Aoun P, Wu D, et al. Prognostic significance of anaplastic lymphoma kinase (ALK) protein expression in adults with anaplastic large cell lymphoma. Blood. 1999;93:3913\u20133921.","DOI":"10.1182\/blood.V93.11.3913"},{"key":"2019111709593716000_R6","doi-asserted-by":"crossref","unstructured":"Rodriguez J, Caballero MD, Gutierrez A, et al. High-dose chemotherapy and autologous stem cell transplantation in peripheral T-cell lymphoma: the GEL-TAMO experience. Ann Oncol. 2003;14:1768\u20131775.","DOI":"10.1093\/annonc\/mdg459"},{"key":"2019111709593716000_R7","doi-asserted-by":"crossref","unstructured":"Rodriguez J, Conde E, Gutierrez A, et al. The results of consolidation with autologous stem-cell transplantation in patients with peripheral T-cell lymphoma (PTCL) in first complete remission: the Spanish Lymphoma and Autologous Transplantation Group experience. Ann Oncol. 2007;18:652\u2013657.","DOI":"10.1093\/annonc\/mdl466"},{"key":"2019111709593716000_R8","doi-asserted-by":"crossref","unstructured":"Jantunen E, Wiklund T, Juvonen E, et al. Autologous stem cell transplantation in adult patients with peripheral T-cell lymphoma: a nation-wide survey. Bone Marrow Transplant. 2004;33:405\u2013410.","DOI":"10.1038\/sj.bmt.1704367"},{"key":"2019111709593716000_R9","doi-asserted-by":"crossref","unstructured":"Reimer P, Schertlin T, Rudiger T, et al. Myeloablative radiochemotherapy followed by autologous peripheral blood stem cell transplantation as first-line therapy in peripheral T-cell lymphomas: first results of a prospective multicenter study. 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Long-term follow-up of patients with peripheral T-cell lymphomas treated up-front with high-dose chemotherapy followed by autologous stem cell transplantation. Leukemia. 2006;20:1533\u20131538.","DOI":"10.1038\/sj.leu.2404306"},{"key":"2019111709593716000_R13","doi-asserted-by":"crossref","unstructured":"Mercadal S, Briones J, Xicoy B, et al. Intensive chemotherapy (high-dose CHOP\/ESHAP regimen) followed by autologous stem-cell transplantation in previously untreated patients with peripheral T-cell lymphoma. Ann Oncol. 2008;19:958\u2013963.","DOI":"10.1093\/annonc\/mdn022"},{"key":"2019111709593716000_R14","doi-asserted-by":"crossref","unstructured":"Gisselbrecht C, Lepage E, Molina T, et al. Shortened first-line high-dose chemotherapy for patients with poor-prognosis aggressive lymphoma. J Clin Oncol. 2002;20:2472\u20132479.","DOI":"10.1200\/JCO.2002.02.125"},{"key":"2019111709593716000_R15","doi-asserted-by":"crossref","unstructured":"Mounier N, Gisselbrecht C, Briere J, et al. Prognostic factors in patients with aggressive non-Hodgkin\u2019s lymphoma treated by front-line autotransplantation after complete remission: a cohort study by the Groupe d\u2019Etude des Lymphomes de l\u2019Adulte. J Clin Oncol. 2004;22:2826\u20132834.","DOI":"10.1200\/JCO.2004.12.032"},{"key":"2019111709593716000_R16","doi-asserted-by":"crossref","unstructured":"Rodriguez J, Conde E, Gutierrez A, et al. Prolonged survival of patients with angioimmunoblastic T-cell lymphoma after high-dose chemotherapy and autologous stem cell transplantation: the GELTAMO experience. Eur J Haematol. 2007;78:290\u2013296.","DOI":"10.1111\/j.1600-0609.2007.00815.x"},{"key":"2019111709593716000_R17","unstructured":"Schetelig J, Fetscher S, Reichle A, et al. Long-term disease-free survival in patients with angioimmunoblastic T-cell lymphoma after high-dose chemotherapy and autologous stem cell transplantation. Haematologica. 2003;88:1272\u20131278."},{"key":"2019111709593716000_R18","unstructured":"Kyriakou C, Canals C, Goldstone A, et al. High-dose therapy and autologous stem-cell transplantation in angioimmunoblastic lymphoma: complete remission at transplantation is the major determinant of outcome\u2014Lymphoma Working Party of the European Group for Blood and Marrow Transplantation. 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