{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:09:09Z","timestamp":1787357349617,"version":"build-2736575974"},"reference-count":42,"publisher":"American Society of Hematology","issue":"1","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2010,12,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Thrombocytopenia occurs commonly during pregnancy, and may result from diverse etiologies. Awareness of these many causes facilitates proper diagnosis and management of thrombocytopenia in the pregnant setting. Some causes of thrombocytopenia are unique to pregnancy and may not be familiar to hematologists. In the review, we will discuss the differential diagnosis of thrombocytopenia in pregnancy, and the pathogenesis of selected thrombocytopenic disorders. Considerations for optimal management of the pregnant patient with thrombocytopenia will also be described.<\/jats:p>","DOI":"10.1182\/asheducation-2010.1.397","type":"journal-article","created":{"date-parts":[[2011,1,16]],"date-time":"2011-01-16T19:08:48Z","timestamp":1295204928000},"page":"397-402","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":89,"title":["Thrombocytopenia in Pregnancy"],"prefix":"10.1182","volume":"2010","author":[{"given":"Keith R.","family":"McCrae","sequence":"first","affiliation":[{"name":"Cleveland Clinic Foundation, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"key":"2019111719503312000_B1","doi-asserted-by":"crossref","first-page":"925","DOI":"10.3109\/9781420014907","volume-title":"Thrombocytopenia in Pregnancy","author":"McCrae","year":"2006"},{"key":"2019111719503312000_B2","first-page":"29","article-title":"Platelet count at term pregnancy: a reappraisal of the threshold","volume":"95","author":"Boehlen","year":"2000","journal-title":"Obstet Gynecol"},{"key":"2019111719503312000_B3","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1182\/blood-2009-06-225565","article-title":"International consensus report on the investigation and management of primary immune thrombocytopenia","volume":"115","author":"Provan","year":"2010","journal-title":"Blood"},{"key":"2019111719503312000_B4","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1097\/00003081-199906000-00017","article-title":"Gestational thrombocytopenia","volume":"42","author":"Shehata","year":"1999","journal-title":"Clin Obstet Gynecol"},{"key":"2019111719503312000_B5","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1056\/NEJM198807213190304","article-title":"Incidentally detected thrombocytopenia in healthy mothers and their infants","volume":"319","author":"Burrows","year":"1988","journal-title":"N Engl J Med"},{"key":"2019111719503312000_B6","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0037-1963(00)90106-9","article-title":"Management of idiopathic thrombocytopenic purpura in pregnancy","volume":"37","author":"Gill","year":"2000","journal-title":"Semin Hematol"},{"key":"2019111719503312000_B7","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.hoc.2009.08.005","article-title":"Immune thrombocytopenia in pregnancy","volume":"23","author":"Stavrou","year":"2009","journal-title":"Hematol Oncol Clin North Am"},{"key":"2019111719503312000_B8","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1097\/00006254-199312000-00003","article-title":"Pregnancy in patients with idiopathic thrombocytopenic purpura: assessing the risks for the infant at delivery","volume":"48","author":"Burrows","year":"1993","journal-title":"Obstet Gynecol Surv"},{"key":"2019111719503312000_B9","doi-asserted-by":"crossref","first-page":"4306","DOI":"10.1182\/blood-2002-10-3317","article-title":"A retrospective 11-year analysis of obstetric patients with idiopathic thromobocytopenic purpura","volume":"102","author":"Webert","year":"2003","journal-title":"Blood"},{"key":"2019111719503312000_B10","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1054\/blre.2001.0181","article-title":"Idiopathic thrombocytopenic purpura complicating pregnancy","volume":"16","author":"Kelton","year":"2002","journal-title":"Blood Rev"},{"key":"2019111719503312000_B11","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1046\/j.1365-2141.2003.04567.x","article-title":"Intravenous anti-D as a treatment for immune thrombocytopenic purpura (ITP) during pregnancy","volume":"123","author":"Michel","year":"2003","journal-title":"Br J Haematol"},{"key":"2019111719503312000_B12","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1155\/2008\/271363","article-title":"Rituximab administration in third trimester of pregnancy suppresses neonatal B-cell development","volume":"2008","author":"Klink","year":"2008","journal-title":"Clin Dev Immunol"},{"key":"2019111719503312000_B13","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/S0029-7844(97)00349-9","article-title":"Comparison of platelet counts in first and second newborns of mothers with immune thrombocytopenic purpura","volume":"90","author":"Christiaens","year":"1997","journal-title":"Obstet Gynecol"},{"key":"2019111719503312000_B14","first-page":"578","article-title":"Immune thrombocytopenic purpura in pregnancy: a reappraisal of management","volume":"78","author":"Cook","year":"1991","journal-title":"Obstet Gynecol"},{"key":"2019111719503312000_B15","first-page":"159","article-title":"ACOG Practice Bulletin: diagnosis and management of preeclampsia in pregnancy","volume":"99","author":"American College of Obstet Gynecol","year":"2002","journal-title":"Obstet Gynecol"},{"key":"2019111719503312000_B16","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1053\/j.semperi.2009.02.007","article-title":"Pre-eclampsia and the kidney","volume":"33","author":"Mirza","year":"2009","journal-title":"Semin Perinatol"},{"key":"2019111719503312000_B17","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1146\/annurev-pathol-121808-102149","article-title":"Pathogenesis of preeclampsia","volume":"5","author":"Young","year":"2010","journal-title":"Annu Rev Pathol"},{"key":"2019111719503312000_B18","doi-asserted-by":"crossref","first-page":"1R","DOI":"10.1203\/01.PDR.0000159567.85157.B7","article-title":"Soluble Fms-like tyrosine kinase 1 and endothelial dysfunction in the pathogenesis of preeclampsia","volume":"57","author":"Maynard","year":"2005","journal-title":"Pediatr Res"},{"key":"2019111719503312000_B19","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/nm1429","article-title":"Soluble endoglin contributes to the pathogenesis of preeclampsia","volume":"12","author":"Venkatesha","year":"2006","journal-title":"Nat Med"},{"key":"2019111719503312000_B20","doi-asserted-by":"crossref","first-page":"711","DOI":"10.2174\/092986708783885309","article-title":"A possible placental factor for preeclampsia: sFlt-1","volume":"15","author":"Kita","year":"2008","journal-title":"Curr Med Chem"},{"key":"2019111719503312000_B21","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1538-7836.2008.03259.x","article-title":"Vascular biology of preeclampsia","volume":"7","author":"Myatt","year":"2009","journal-title":"J Thromb Haemost"},{"key":"2019111719503312000_B22","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1179\/acb.2010.020","article-title":"The HELLP syndrome","volume":"65","author":"Kirkpatrick","year":"2010","journal-title":"Acta Clin Belg"},{"key":"2019111719503312000_B23","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1146\/annurev-pathol-121808-102149","article-title":"Pathogenesis of preeclampsia","volume":"5","author":"Young","year":"2010","journal-title":"Annu Rev Pathol"},{"key":"2019111719503312000_B24","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.clp.2004.06.008","article-title":"Diagnosis and management of hemolysis, elevated liver enzymes and low platelets syndrome","volume":"31","author":"Barton","year":"2004","journal-title":"Clin Perinatol"},{"key":"2019111719503312000_B25","first-page":"148","article-title":"Thrombotic microangiopathy during pregnancy","volume":"34","author":"McCrae","year":"1997","journal-title":"Semin Hematol"},{"key":"2019111719503312000_B26","doi-asserted-by":"crossref","first-page":"4542","DOI":"10.1182\/blood-2008-03-144691","article-title":"Factor H, membrane cofactor protein, and factor I mutations in patients with hemolysis, elevated liver enzymes, and low platelet count syndrome","volume":"112","author":"Fakhouri","year":"2008","journal-title":"Blood"},{"key":"2019111719503312000_B27","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jash.2010.03.002","article-title":"Hypertension in pregnancy","volume":"4","author":"Lindheimer","year":"2010","journal-title":"J Am Soc Hypertens"},{"key":"2019111719503312000_B28","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1053\/j.semperi.2007.03.005","article-title":"Preeclampsia recurrence and prevention","volume":"31","author":"Dildy","year":"2007","journal-title":"Semin Perinatol"},{"key":"2019111719503312000_B29","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1016\/S0140-6736(07)60712-0","article-title":"Antiplatelet agents for prevention of pre-eclampsia: a meta-analysis of individual patient data","volume":"369","author":"Askie","year":"2007","journal-title":"Lancet"},{"key":"2019111719503312000_B30","first-page":"2099","article-title":"Thrombotic thrombocytopenic purpura and the hemolytic uremic syndrome","volume-title":"Hematology: Basic Principles and Practice","author":"McCrae","year":"2009"},{"key":"2019111719503312000_B31","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1038\/ki.2008.609","article-title":"The thrombotic thrombocytopenic purpura and hemolytic uremic syndromes: evaluation, management, and long-term outcomes experience of the Oklahoma TTP-HUS Registry, 1989\u20132007","volume":"112","author":"George","year":"2009","journal-title":"Kidney Int. Supp"},{"key":"2019111719503312000_B32","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/ncpneph0670","article-title":"Does hemolytic uremic syndrome differ from thrombotic thrombocytopenic purpura?","volume":"3","author":"Fakhouri","year":"2007","journal-title":"Nat Clin Pract Nephrol"},{"key":"2019111719503312000_B33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12185-009-0476-1","article-title":"Pathophysiology of thrombotic thrombocytopenic purpura","volume":"91","author":"Tsai","year":"2010","journal-title":"Int J Hematol"},{"key":"2019111719503312000_B34","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1056\/NEJM199811263392203","article-title":"Antibodies to von Willebrand factor-cleaving protease in acute thrombotic thrombocytopenic purpura","volume":"339","author":"Tsai","year":"1998","journal-title":"N Engl J Med"},{"key":"2019111719503312000_B35","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/humu.21143","article-title":"ADAMTS13 mutations and polymorphisms in congenital thrombotic thrombocytopenic purpura","volume":"31","author":"Lotta","year":"2010","journal-title":"Hum Mutat"},{"key":"2019111719503312000_B36","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.ajog.2008.03.011","article-title":"Thrombotic thrombocytopenic purpura in 166 pregnancies: 1955\u20132006","volume":"199","author":"Martin","year":"2008","journal-title":"Am J Obstet Gynecol"},{"key":"2019111719503312000_B37","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1111\/j.1365-2141.2008.07515.x","article-title":"Pregnancy-induced thrombocytopenia and TTP, and the risk of fetal death, in Upshaw-Schulman syndrome: a series of 15 pregnancies in 9 genotyped patients","volume":"144","author":"Fujimura","year":"2009","journal-title":"Br J Haematol"},{"key":"2019111719503312000_B38","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1097\/MOH.0b013e328309ec62","article-title":"Current management of thrombotic thrombocytopenic purpura","volume":"15","author":"Kremer Hovinga","year":"2008","journal-title":"Curr Opin Hematol"},{"key":"2019111719503312000_B39","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1146\/annurev.med.59.060106.185110","article-title":"Complement regulatory genes and hemolytic uremic syndrome","volume":"59","author":"Kavanagh","year":"2008","journal-title":"Ann Rev Med"},{"key":"2019111719503312000_B40","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1681\/ASN.2009070706","article-title":"Pregnancy-associated hemolytic uremic syndrome revisited in the era of complement gene mutations","volume":"21","author":"Fakhouri","year":"2010","journal-title":"J Am Soc. Nephrol"},{"key":"2019111719503312000_B41","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1016\/j.ajog.2004.12.035","article-title":"Acute fatty liver of pregnancy in 3 tertiary care centers","volume":"192","author":"Fesenmeir","year":"2005","journal-title":"Am J Obstet Gynecol"},{"key":"2019111719503312000_B42","first-page":"1793","article-title":"Microangiopathic antiphospholipid-associated syndromes revisited new concepts relating to antiphospholipid antibodies and syndromes","volume":"34","author":"Asherson","year":"2007","journal-title":"J Rheumatol"}],"container-title":["Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/ashpublications.org\/hematology\/article-pdf\/2010\/1\/397\/1493504\/bep00110000397.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/ashpublications.org\/hematology\/article-pdf\/2010\/1\/397\/1493504\/bep00110000397.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T13:47:24Z","timestamp":1637156844000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/hematology\/article\/2010\/1\/397\/96387\/Thrombocytopenia-in-Pregnancy"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,4]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,12,4]]}},"URL":"https:\/\/doi.org\/10.1182\/asheducation-2010.1.397","relation":{},"ISSN":["1520-4391","1520-4383"],"issn-type":[{"value":"1520-4391","type":"print"},{"value":"1520-4383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,4]]}}}