{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:24:26Z","timestamp":1791051866118,"version":"4.1.0"},"reference-count":54,"publisher":"American Society of Hematology","issue":"1","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,12,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Allogeneic HSCT controls sickle cell disease (SCD)\u2013related organ damage and is currently the only curative therapy available. Over the last 2 decades, HSCT has been limited largely to myeloablative matched sibling donor (MSD) procedures that are feasible only in a minority of patients. As the natural history of the disease has evolved, it is clear that subsets of patients with severe disease are at risk for sudden death, devastating CNS and pulmonary complications, and debilitating vasoocclusive crises. For these patients, the benefits of transplantation can outweigh the risks if HSCT can be safely and successfully performed with low early and late toxicities. This review describes advances and ongoing investigation of HSCT for SCD from the perspectives of recipient age and presentation, donor stem cell source, intensity of conditioning, family and medical perspectives, and other variables that influence outcome. Ultimately, HSCT should be viewed as a viable treatment option for SCD on par with other therapies for select patients who can benefit from the procedure.<\/jats:p>","DOI":"10.1182\/asheducation-2011.1.273","type":"journal-article","created":{"date-parts":[[2011,12,7]],"date-time":"2011-12-07T20:33:13Z","timestamp":1323289993000},"page":"273-279","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":50,"title":["Hematopoietic Stem Cell Transplantation for Sickle Cell Disease: Current Practice and Emerging Trends"],"prefix":"10.1182","volume":"2011","author":[{"given":"Shalini","family":"Shenoy","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology, Washington University, St Louis Children's Hospital, St Louis, MO"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"key":"2019111716221923800_B1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/ajh.21952","article-title":"Reconstructing sickle cell disease: a data-based analysis of the \u201chyperhemolysis paradigm\u201d for pulmonary hypertension from the perspective of evidence-based medicine","volume":"86","author":"Hebbel","year":"2011","journal-title":"Am J Hematol"},{"key":"2019111716221923800_B2","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1055\/s-0031-1273087","article-title":"Thrombosis and sickle cell disease","volume":"37","author":"De Franceschi","year":"2011","journal-title":"Semin Thromb Hemost"},{"key":"2019111716221923800_B3","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1182\/blood-2010-02-268193","article-title":"Pulmonary hypertension and nitric oxide depletion in sickle cell disease","volume":"116","author":"Bunn","year":"2010","journal-title":"Blood"},{"key":"2019111716221923800_B4","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1097\/MOH.0b013e32834521dd","article-title":"Hydroxyurea for sickle cell anemia: what have we learned and what questions still remain?","volume":"18","author":"McGann","year":"2011","journal-title":"Curr Opin Hematol"},{"key":"2019111716221923800_B5","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1182\/blood-2007-07-100719","article-title":"Prediction of adverse outcomes in children with sickle cell anemia: a study of the Dallas Newborn Cohort","volume":"111","author":"Quinn","year":"2008","journal-title":"Blood"},{"key":"2019111716221923800_B6","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1002\/pbc.22951","article-title":"Effect of transfusion therapy on transcranial Doppler ultrasonography velocities in children with sickle cell disease","volume":"56","author":"Kwiatkowski","year":"2011","journal-title":"Pediatr Blood Cancer"},{"key":"2019111716221923800_B7","first-page":"288","article-title":"Cerebrovascular accidents in sickle cell disease rates and risk factors","volume":"91","author":"Ohene-Frempong","year":"1998","journal-title":"Blood"},{"key":"2019111716221923800_B8","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1542\/peds.103.3.640","article-title":"Silent cerebral infarcts in sickle cell anemia: a risk factor analysis. 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