{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T12:55:04Z","timestamp":1762001704841},"reference-count":13,"publisher":"American Society of Hematology","issue":"1","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,12,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 16-year-old female diagnosed with acute myeloid leukemia (AML) with inversion 16, a favorable prognostic indicator, has persistent neutropenia after her fourth cycle of dose-intensified chemotherapy. She was recently admitted for treatment with empiric antibiotics for febrile neutropenia, and an astute intern noticed a new lesion on her right foot with a dark necrotic center. A biopsy of the lesion showed spreading hyphae, consistent with Aspergillus. Despite her compliance with fluconazole fungal prophylaxis, computed tomography imaging revealed disseminated aspergillosis involving her lungs, liver, and kidneys. Amphotericin was started, but systemic fungemia and the development of multiorgan failure resulted in her death. You are in the difficult position of having to explain to her parents that she died in remission from chemotherapy-related complications. All of those involved in this unfortunate scenario wonder if something could have been done to prevent her death.<\/jats:p>","DOI":"10.1182\/asheducation-2011.1.374","type":"journal-article","created":{"date-parts":[[2011,12,7]],"date-time":"2011-12-07T20:33:13Z","timestamp":1323289993000},"page":"374-376","update-policy":"http:\/\/dx.doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":3,"title":["Recommendations for Broader Coverage Antifungal Prophylaxis in Childhood Acute Myeloid Leukemia: ASH Evidence-Based Review 2011"],"prefix":"10.1182","volume":"2011","author":[{"given":"Maria M.","family":"Gramatges","sequence":"first","affiliation":[{"name":"Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, TX; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart S.","family":"Winter","sequence":"additional","affiliation":[{"name":"University of New Mexico Health Sciences Center, Albuquerque, NM"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"234","reference":[{"key":"2019111716213058300_B1","doi-asserted-by":"crossref","first-page":"3532","DOI":"10.1182\/blood-2007-05-091942","article-title":"Microbiologically documented infections and infection-related mortality in children with acute myeloid leukemia","volume":"110","author":"Sung","year":"2007","journal-title":"Blood"},{"key":"2019111716213058300_B2","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1182\/blood.V112.11.136.136","article-title":"Efficacy and safety in a pilot study of intensive chemotherapy including gemtuzumab in children newly diagnosed with acute myeloid leukemia (AML) [Abstract]","volume":"112","author":"Franklin","year":"2008","journal-title":"Blood"},{"key":"2019111716213058300_B3","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1164\/rccm.200207-682OC","article-title":"The epidemiology of severe sepsis in children in the United States","volume":"167","author":"Watson","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"2019111716213058300_B4","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1046\/j.1439-0507.1999.00496.x","article-title":"Five-year-survey of invasive aspergillosis in a paediatric cancer centre. 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