{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:18:28Z","timestamp":1787019508003,"version":"build-2736575974"},"reference-count":69,"publisher":"American Society of Hematology","issue":"1","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,12,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Low-grade mucosa-associated lymphoid tissue (MALT) lymphoma of the stomach, gastric MALT lymphoma, is associated with Helicobacter pylori infection. The eradication of H pylori using antibiotics is successful in 60% to 80% of affected patients. In contrast to the previous paradigm, we and other investigators have shown that a certain proportion of patients with H pylori\u2013positive early-stage diffuse large B-cell lymphoma (DLBCL) of the stomach with histological evidence of MALT lymphoma, including high-grade transformed gastric MALT lymphoma and gastric DLBCL(MALT), achieved long-term complete pathological remission (pCR) after first-line H pylori eradication therapy, indicating that the loss of H pylori dependence and high-grade transformation are separate events in the progression of gastric lymphoma. In addition, patients with H pylori\u2013positive gastric DLBCL without histological evidence of MALT (gastric pure DLBCL) may also respond to H pylori eradication therapy. A long-term follow-up study showed that patients who achieved pCR remained lymphoma free. Gastric MALT lymphoma is indirectly influenced by H pylori infection through T-cell stimulation, and recent studies have shown that H pylori\u2013triggering chemokines and their receptors, H pylori\u2013associated epigenetic changes, H pylori\u2013regulated miRNA expression, and tumor infiltration by CD4+CD25+ regulatory T cells contribute to lymphomagenesis of gastric MALT lymphoma. Recent studies have also demonstrated that the translocation of CagA into B lymphocytes inhibits apoptosis through p53 accumulation, BAD phosphorylation, and the up-regulation of Bcl-2 and Bcl-XL expression. In gastric MALT lymphoma, CagA may stimulate lymphomagenesis directly, through the regulation of signal transduction, and intracellular CagA is associated with H pylori dependence. These findings represent a substantial paradigm shift compared with the classical theory of H pylori\u2013reactive T cells contributing indirectly to the development of MALT lymphoma. In conclusion, a wide range of H pylori\u2013related gastric lymphomas have been identified. The use of antibiotics as the sole first-line therapy for early-stage gastric pure DLBCL requires validation in a prospective study. The clinical and biological significance of the CagA oncoprotein in the lymphomagenesis of gastric MALT lymphoma warrants further study.<\/jats:p>","DOI":"10.1182\/asheducation-2013.1.109","type":"journal-article","created":{"date-parts":[[2013,12,6]],"date-time":"2013-12-06T10:51:13Z","timestamp":1386327073000},"page":"109-117","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":51,"title":["Helicobacter pylori and mucosa-associated lymphoid tissue: what's new"],"prefix":"10.1182","volume":"2013","author":[{"given":"Sung-Hsin","family":"Kuo","sequence":"first","affiliation":[{"name":"Departments of Oncology and"},{"name":"Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; and"},{"name":"Cancer Research Center and"},{"name":"Graduate Institute of Oncology, National Taiwan University College of Medicine, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann-Lii","family":"Cheng","sequence":"additional","affiliation":[{"name":"Departments of Oncology and"},{"name":"Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; and"},{"name":"Cancer Research Center and"},{"name":"Graduate Institute of Oncology, National Taiwan University College of Medicine, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"issue":"8","key":"2019111702483558000_B1","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1002\/1097-0142(19831015)52:8<1410::AID-CNCR2820520813>3.0.CO;2-3","article-title":"Malignant lymphoma of mucosa-associated lymphoid tissue. A distinct type of B-cell lymphoma","volume":"52","author":"Isaacson","year":"1983","journal-title":"Cancer"},{"key":"2019111702483558000_B2","volume-title":"Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues. WHO Classification of Tumours","author":"Jaffe","year":"2001"},{"key":"2019111702483558000_B3","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissue","author":"Swerdlow","year":"2008"},{"issue":"8390","key":"2019111702483558000_B4","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/S0140-6736(84)91816-6","article-title":"Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration","volume":"1","author":"Marshall","year":"1984","journal-title":"Lancet"},{"issue":"2","key":"2019111702483558000_B5","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/path.1703","article-title":"Gastrointestinal lymphoma: where morphology meets molecular biology","volume":"205","author":"Isaacson","year":"2005","journal-title":"J Pathol"},{"issue":"8776","key":"2019111702483558000_B6","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/0140-6736(91)92035-Z","article-title":"Helicobacter pylori associated gastritis and primary B-cell gastric lymphoma","volume":"338","author":"Wotherspoon","year":"1991","journal-title":"Lancet"},{"issue":"8871","key":"2019111702483558000_B7","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/0140-6736(93)91409-F","article-title":"Regression of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori","volume":"342","author":"Wotherspoon","year":"1993","journal-title":"Lancet"},{"issue":"2","key":"2019111702483558000_B8","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S1470-2045(02)00651-4","article-title":"Gastric MALT lymphoma: from aetiology to treatment","volume":"3","author":"Du","year":"2002","journal-title":"Lancet Oncol"},{"issue":"6","key":"2019111702483558000_B9","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1053\/j.gastro.2005.03.083","article-title":"Helicobacter pylori and MALT lymphoma","volume":"128","author":"Farinha","year":"2005","journal-title":"Gastroenterology"},{"key":"2019111702483558000_B10","doi-asserted-by":"crossref","first-page":"S151","DOI":"10.1111\/j.1440-1746.2008.05553.x","article-title":"Gene expression profiling in Helicobacter-induced MALT lymphoma with reference to antigen drive and protective immunization","volume":"23","author":"O'Rourke","year":"2008","journal-title":"J Gastroenterol Hepatol"},{"issue":"2","key":"2019111702483558000_B11","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.cgh.2009.07.017","article-title":"Effects of Helicobacter pylori eradication on early stage gastric mucosa-associated lymphoid tissue lymphoma","volume":"8","author":"Zullo","year":"2010","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"6","key":"2019111702483558000_B12","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1136\/gut.2010.224949","article-title":"on behalf of the EGILS group. EGILS consensus report. Gastric extranodal marginal zone B-cell lymphoma of MALT","volume":"60","author":"Ruskon\u00e9-Fourmestraux","year":"2011","journal-title":"Gut"},{"issue":"18","key":"2019111702483558000_B13","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1093\/jnci\/89.18.1350","article-title":"Cure of Helicobacter pylori infection and duration of remission of low-grade gastric mucosa-associated lymphoid tissue lymphoma","volume":"89","author":"Neubauer","year":"1997","journal-title":"J Natl Cancer Inst"},{"issue":"12","key":"2019111702483558000_B14","doi-asserted-by":"crossref","first-page":"4384","DOI":"10.1182\/blood-2008-07-077982","article-title":"Classification of lymphoid neoplasms: the microscope as a tool for disease discovery","volume":"112","author":"Jaffe","year":"2008","journal-title":"Blood"},{"issue":"22","key":"2019111702483558000_B15","doi-asserted-by":"crossref","first-page":"4245","DOI":"10.1200\/JCO.2001.19.22.4245","article-title":"Prospective study of Helicobacter pylori eradication therapy in stage I(E) high-grade mucosa-associated lymphoid tissue lymphoma of the stomach","volume":"19","author":"Chen","year":"2001","journal-title":"J Clin Oncol"},{"issue":"7","key":"2019111702483558000_B16","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1200\/JCO.2001.19.7.2041","article-title":"Complete remission of primary high-grade B-cell gastric lymphoma after cure of Helicobacter pylori infection","volume":"19","author":"Morgner","year":"2001","journal-title":"J Clin Oncol"},{"issue":"4","key":"2019111702483558000_B17","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1136\/gut.48.4.454","article-title":"Predictive value of endoscopic ultrasonography for regression of gastric low grade and high grade MALT lymphomas after eradication of Helicobacter pylori","volume":"48","author":"Nakamura","year":"2001","journal-title":"Gut"},{"issue":"6","key":"2019111702483558000_B18","first-page":"1207","article-title":"Helicobacter pylori eradication therapy for high-grade mucosaassociated lymphoid tissue lymphomas of the stomach with analysis of p53 and K-ras alteration and microsatellite instability","volume":"18","author":"Hiyama","year":"2001","journal-title":"Int J Oncol"},{"key":"2019111702483558000_B19","doi-asserted-by":"crossref","first-page":"B106","DOI":"10.1007\/PL00022770","article-title":"Helicobacter pylori eradication therapy in gastric high grade non Hodgkin's lymphoma (NHL)","volume":"80","author":"Alpen","year":"2001","journal-title":"Ann Hematol"},{"issue":"18","key":"2019111702483558000_B20","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1093\/jnci\/dji277","article-title":"Long-term results of anti-Helicobacter pylori therapy in early-stage gastric high-grade transformed MALT lymphoma","volume":"97","author":"Chen","year":"2005","journal-title":"J Natl Cancer Inst"},{"issue":"21","key":"2019111702483558000_B21","doi-asserted-by":"crossref","first-page":"4838","DOI":"10.1182\/blood-2012-01-404194","article-title":"Helicobacter pylori eradication therapy is effective in the treatment of early-stage H pylori-positive gastric diffuse large B-cell lymphomas","volume":"119","author":"Kuo","year":"2012","journal-title":"Blood"},{"issue":"8","key":"2019111702483558000_B22","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1038\/ajg.2009.314","article-title":"Eradication therapy for Helicobacter pylori in patients with gastric MALT lymphoma: a pooled data analysis","volume":"104","author":"Zullo","year":"2009","journal-title":"Am J Gastroenterol"},{"issue":"18","key":"2019111702483558000_B23","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1056\/NEJM199405053301803","article-title":"Helicobacter pylori infection and gastric lymphoma","volume":"330","author":"Parsonnet","year":"1994","journal-title":"N Engl J Med"},{"issue":"7","key":"2019111702483558000_B24","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1093\/carcin\/bgi334","article-title":"A past history of gastric ulcers and Helicobacter pylori infection increase the risk of gastric malignant lymphoma","volume":"27","author":"Suzuki","year":"2006","journal-title":"Carcinogenesis"},{"key":"2019111702483558000_B25","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1477-7819-6-35","article-title":"High grade B-cell gastric lymphoma with complete pathologic remission after eradication of Helicobacter pylori infection: report of a case and review of the literature","volume":"6","author":"Cavanna","year":"2008","journal-title":"World J Surg Oncol"},{"issue":"18","key":"2019111702483558000_B26","doi-asserted-by":"crossref","first-page":"3858","DOI":"10.1182\/blood-2012-06-438424","article-title":"Helicobacter pylori eradication as exclusive treatment for limited-stage gastric diffuse large B-cell lymphoma: results of a multicenter phase 2 trial","volume":"120","author":"Ferreri","year":"2012","journal-title":"Blood"},{"issue":"4","key":"2019111702483558000_B27","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1443-1661.2009.00896.x","article-title":"Predictive value of endoscopy and endoscopic ultrasonography for regression of gastric diffuse large B-cell lymphomas after Helicobacter pylori eradication","volume":"21","author":"Tari","year":"2009","journal-title":"Dig Endosc"},{"issue":"1","key":"2019111702483558000_B28","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.bpg.2009.12.005","article-title":"Long-term follow-up of gastric lymphoma after stomach conserving treatment","volume":"24","author":"Fischbach","year":"2010","journal-title":"Best Pract Res Clin Gastroenterol"},{"issue":"21","key":"2019111702483558000_B29","doi-asserted-by":"crossref","first-page":"4818","DOI":"10.1182\/blood-2012-03-417345","article-title":"Antibiotics as first-line therapy for Hp-associated gastric large B-cell lymphoma? Probably yes","volume":"119","author":"M\u00f6ller","year":"2012","journal-title":"Blood"},{"issue":"4","key":"2019111702483558000_B30","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1002\/gcc.1150","article-title":"Molecular-cytogenetic comparison of mucosa associated marginal zone B-cell lymphoma and large B-cell lymphoma arising in the gastro-intestinal tract","volume":"31","author":"Barth","year":"2001","journal-title":"Genes Chromosomes Cancer"},{"issue":"3","key":"2019111702483558000_B31","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/path.2096","article-title":"Transcriptional profiling suggests that secondary and primary large B-cell lymphomas of the gastrointestinal (GI) tract are blastic variants of GI marginal zone lymphoma","volume":"211","author":"Barth","year":"2007","journal-title":"J Pathol"},{"issue":"3","key":"2019111702483558000_B32","first-page":"453","article-title":"Extranodal non-Hodgkin's lymphomas-a retrospective review of clinico-pathologic features and outcomes in comparison with nodal non-Hodgkin's lymphomas","volume":"9","author":"Lal","year":"2008","journal-title":"Asian Pac J Cancer Prev"},{"issue":"7","key":"2019111702483558000_B33","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1093\/annonc\/mdf178","article-title":"Chemotherapy for management of localised high-grade gastric B-cell lymphoma: how much is necessary?","volume":"13","author":"Raderer","year":"2002","journal-title":"Ann Oncol"},{"key":"2019111702483558000_B34","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1158\/1538-7445.AM10-1747","article-title":"Helicobacter pylori-positive diffuse large B-cell lymphoma: a distinct clinicopathologic entity","volume":"70","author":"Kuo","year":"2010","journal-title":"Cancer Res"},{"key":"2019111702483558000_B35","doi-asserted-by":"crossref","first-page":"104918","DOI":"10.1155\/2010\/104918","article-title":"Cytotoxic T cells in H pylori-related gastric autoimmunity and gastric lymphoma","volume":"2010","author":"Bergman","year":"2010","journal-title":"J Biomed Biotechnol"},{"issue":"3","key":"2019111702483558000_B36","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/1096-9896(2000)9999:9999<::AID-PATH811>3.0.CO;2-Z","article-title":"Histological and immunological parameters to predict treatment outcome of Helicobacter pylori eradication in low-grade gastric MALT lymphoma","volume":"193","author":"de Jong","year":"2001","journal-title":"J Pathol"},{"issue":"28","key":"2019111702483558000_B37","doi-asserted-by":"crossref","first-page":"4357","DOI":"10.3748\/wjg.v11.i28.4357","article-title":"Expression of CD86 and increased infiltration of NK cells are associated with Helicobacter pylori-dependent state of early stage high-grade gastric MALT lymphoma","volume":"11","author":"Kuo","year":"2005","journal-title":"World J Gastroenterol"},{"issue":"1","key":"2019111702483558000_B38","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1365-2559.2010.03699.x","article-title":"MALT lymphoma: many roads lead to nuclear factor-\u03bab activation","volume":"58","author":"Du","year":"2011","journal-title":"Histopathology"},{"issue":"3","key":"2019111702483558000_B39","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1182\/blood-2009-06-228015","article-title":"Gastric MALT lymphoma B cells express polyreactive, somatically mutated immunoglobulins","volume":"115","author":"Craig","year":"2010","journal-title":"Blood"},{"key":"2019111702483558000_B40","doi-asserted-by":"crossref","first-page":"R49","DOI":"10.1172\/JCI7830","article-title":"BCA-1 is highly expressed in Helicobacter pylori-induced mucosa-associated lymphoid tissue and gastric lymphoma","volume":"104","author":"Mazzucchelli","year":"1999","journal-title":"J Clin Invest"},{"issue":"2","key":"2019111702483558000_B41","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1080\/1042819031000060546","article-title":"Expression of chemokine receptor CXCR3 and its ligand, mig, in gastric and thyroid marginal zone lymphomas. Possible migration and autocrine mechanism","volume":"44","author":"Ohshima","year":"2003","journal-title":"Leuk Lymphoma"},{"issue":"9","key":"2019111702483558000_B42","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1111\/j.1349-7006.2008.00883.x","article-title":"Significance of CXCR3 expression in gastric low-grade B-cell lymphoma of mucosa-associated lymphoid tissue type for predicting responsiveness to Helicobacter pylori eradication","volume":"99","author":"Yamamoto","year":"2008","journal-title":"Cancer Sci"},{"key":"2019111702483558000_B43","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/modpathol.2012.134","article-title":"Chemokine receptors in gastric MALT lymphoma: loss of CXCR4 and upregulation of CXCR7 is associated with progression to diffuse large B-cell lymphoma","volume":"26","author":"Deutsch","year":"2013","journal-title":"Mod Pathol"},{"issue":"1-2","key":"2019111702483558000_B44","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/j.0300-9475.2004.01447.x","article-title":"Antigen-specific in vitro suppression of murine Helicobacter pylori-reactive immunopathological T cells by CD4+CD25+ regulatory T cells","volume":"60","author":"Raghavan","year":"2004","journal-title":"Scand J Immunol"},{"issue":"4","key":"2019111702483558000_B45","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/ni904","article-title":"Foxp3 programs the development and function of CD4+CD25+ regulatory T cells","volume":"4","author":"Fontenot","year":"2003","journal-title":"Nat Immunol"},{"issue":"6","key":"2019111702483558000_B46","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1038\/leu.2010.76","article-title":"B-cell receptor signaling and CD40 ligand-independent T cell help cooperate in Helicobacter-induced MALT lymphomagenesis","volume":"24","author":"Craig","year":"2010","journal-title":"Leukemia"},{"issue":"12","key":"2019111702483558000_B47","doi-asserted-by":"crossref","first-page":"e51681","DOI":"10.1371\/journal.pone.0051681","article-title":"Study of regulatory T-cells in patients with gastric malt lymphoma: influence on treatment response and outcome","volume":"7","author":"Garc\u00eda","year":"2012","journal-title":"PLoS One"},{"issue":"5","key":"2019111702483558000_B48","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/hel.12051","article-title":"High levels of FOXP3+ regulatory T cells in gastric MALT lymphoma predict responsiveness to Helicobacter pylori eradication","volume":"18","author":"Iwaya","year":"2013","journal-title":"Helicobacter"},{"issue":"14","key":"2019111702483558000_B49","doi-asserted-by":"crossref","first-page":"5740","DOI":"10.1158\/0008-5472.CAN-09-4690","article-title":"Translocation of Helicobacter pylori CagA into Human B lymphocytes, the origin of mucosa-associated lymphoid tissue lymphoma","volume":"70","author":"Lin","year":"2010","journal-title":"Cancer Res"},{"key":"2019111702483558000_B50","doi-asserted-by":"crossref","first-page":"e125","DOI":"10.1038\/bcj.2013.22","article-title":"Detection of the Helicobacter pylori CagA protein in gastric mucosa-associated lymphoid tissue lymphoma cells: clinical and biological significance","volume":"3","author":"Kuo","year":"2013","journal-title":"Blood Cancer J"},{"key":"2019111702483558000_B51","doi-asserted-by":"crossref","first-page":"ix351","DOI":"10.1016\/S0923-7534(20)33630-9","article-title":"Detection of CagA expression in gastric mucosa-associated lymphoid Tissue lymphoma\u2013biological significance and clinical implication","volume":"23","author":"Kuo","year":"2012","journal-title":"Ann Oncol"},{"issue":"3","key":"2019111702483558000_B52","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1073\/pnas.0711183105","article-title":"Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse","volume":"105","author":"Ohnishi","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"51","key":"2019111702483558000_B53","doi-asserted-by":"crossref","first-page":"8337","DOI":"10.1038\/sj.onc.1207028","article-title":"Effects of Helicobacter pylori CagA protein on the growth and survival of B lymphocytes, the origin of MALT lymphoma","volume":"22","author":"Umehara","year":"2003","journal-title":"Oncogene"},{"issue":"4","key":"2019111702483558000_B54","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1111\/j.1462-5822.2006.00843.x","article-title":"The Helicobacter pylori virulence factor CagA promotes Erk1\/2-mediated Bad phosphorylation in lymphocytes: a mechanism of CagA-inhibited lymphocyte apoptosis","volume":"9","author":"Zhu","year":"2007","journal-title":"Cell Microbiol"},{"issue":"6","key":"2019111702483558000_B55","doi-asserted-by":"crossref","first-page":"e39199","DOI":"10.1371\/journal.pone.0039199","article-title":"Persistent Helicobacter pylori specific Th17 responses in patients with past H pylori infection are associated with elevated gastric mucosal IL-1\u03b2","volume":"7","author":"Serelli-Lee","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"2019111702483558000_B56","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s535-002-8127-8","article-title":"Regression of low-grade gastric mucosa-associated lymphoid tissue lymphoma after eradication of Helicobacter pylori: possible association with p16 hypermethylation","volume":"37","author":"Kim","year":"2002","journal-title":"J Gastroenterol"},{"issue":"10","key":"2019111702483558000_B57","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1080\/10428190701573224","article-title":"Promoter hypermethylation of multiple genes in gastric lymphoma","volume":"48","author":"Huang","year":"2007","journal-title":"Leuk Lymphoma"},{"issue":"4","key":"2019111702483558000_B58","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1159\/000195698","article-title":"Methylation of p16INK4A and mitotic arrest defective protein 2 (MAD2) genes in gastric marginal-zone B-cell lymphomas","volume":"120","author":"Park","year":"2008","journal-title":"Acta Haematol"},{"issue":"3","key":"2019111702483558000_B59","first-page":"547","article-title":"Accumulation of aberrant CpG hypermethylation by Helicobacter pylori infection promotes development and progression of gastric MALT lymphoma","volume":"35","author":"Kondo","year":"2009","journal-title":"Int J Oncol"},{"issue":"2","key":"2019111702483558000_B60","doi-asserted-by":"crossref","first-page":"e57","DOI":"10.1038\/bcj.2012.1","article-title":"MicroRNA signatures in B-cell lymphomas","volume":"2","author":"Di Lisio","year":"2012","journal-title":"Blood Cancer J"},{"issue":"11","key":"2019111702483558000_B61","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1038\/modpathol.2010.139","article-title":"E2A-positive gastric MALT lymphoma has weaker plasmacytoid infiltrates and stronger expression of the memory B-cell-associated miR-223: possible correlation with stage and treatment response","volume":"23","author":"Liu","year":"2010","journal-title":"Mod Pathol"},{"issue":"10","key":"2019111702483558000_B62","doi-asserted-by":"crossref","first-page":"3616","DOI":"10.1158\/0008-5472.CAN-10-3907","article-title":"Epigenetic silencing of microRNA-203 dysregulates ABL1 expression and drives Helicobacter-associated gastric lymphomagenesis","volume":"71","author":"Craig","year":"2011","journal-title":"Cancer Res"},{"issue":"11","key":"2019111702483558000_B63","doi-asserted-by":"crossref","first-page":"e47396","DOI":"10.1371\/journal.pone.0047396","article-title":"Overexpression of miR-142-5p and miR-155 in gastric mucosa-associated lymphoid tissue (MALT) lymphoma resistant to Helicobacter pylori eradication","volume":"7","author":"Saito","year":"2012","journal-title":"PLoS One"},{"key":"2019111702483558000_B64","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1182\/asheducation.V2012.1.426.3798535","article-title":"The many faces of marginal zone lymphoma","volume":"2012","author":"Zinzani","year":"2012","journal-title":"Hematology Am Soc Hematol Educ Program"},{"issue":"9","key":"2019111702483558000_B65","doi-asserted-by":"crossref","first-page":"913","DOI":"10.18632\/oncotarget.655","article-title":"Bruton's tyrosine kinase: oncotarget in myeloma","volume":"3","author":"Tai","year":"2012","journal-title":"Oncotarget"},{"issue":"1","key":"2019111702483558000_B66","doi-asserted-by":"crossref","first-page":"11","DOI":"10.6004\/jnccn.2013.0004","article-title":"Multiple myeloma, version 1.2013","volume":"11","author":"Anderson","year":"2013","journal-title":"J Natl Compr Canc Netw"},{"issue":"3","key":"2019111702483558000_B67","doi-asserted-by":"crossref","first-page":"353","DOI":"10.3324\/haematol.2012.065995","article-title":"A phase II study of lenalidomide in patients with extranodal marginal zone B-cell lymphoma of the mucosa associated lymphoid tissue (MALT lymphoma)","volume":"98","author":"Kiesewetter","year":"2013","journal-title":"Haematologica"},{"issue":"6","key":"2019111702483558000_B68","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1111\/j.1349-7006.2009.01139.x","article-title":"Antibodies to Helicobacter pylori and CagA protein are associated with the response to antibacterial therapy in patients with H pylori-positive API2-MALT1-negative gastric MALT lymphoma","volume":"100","author":"Sumida","year":"2009","journal-title":"Cancer Sci"},{"issue":"7","key":"2019111702483558000_B69","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1182\/blood-2008-02-137513","article-title":"Overexpression of B cell-activating factor of TNF family (BAFF) is associated with Helicobacter pylori-independent growth of gastric diffuse large B-cell lymphoma with histologic evidence of MALT lymphoma","volume":"112","author":"Kuo","year":"2008","journal-title":"Blood"}],"container-title":["Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/ashpublications.org\/hematology\/article-pdf\/2013\/1\/109\/1249726\/bep00113000109.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/ashpublications.org\/hematology\/article-pdf\/2013\/1\/109\/1249726\/bep00113000109.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T00:05:27Z","timestamp":1716249927000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/hematology\/article\/2013\/1\/109\/20755\/Helicobacter-pylori-and-mucosaassociated-lymphoid"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,6]]},"references-count":69,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,12,6]]}},"URL":"https:\/\/doi.org\/10.1182\/asheducation-2013.1.109","relation":{},"ISSN":["1520-4391","1520-4383"],"issn-type":[{"value":"1520-4391","type":"print"},{"value":"1520-4383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,6]]}}}