{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T04:29:09Z","timestamp":1789532949743,"version":"build-2803163510"},"reference-count":38,"publisher":"American Society of Hematology","issue":"1","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,12,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Thrombotic microangiopathy (TMA) is a clinicopathological condition associated with a wide variety of medical conditions. TMA is classically characterized by microangiopathic hemolytic anemia, thrombocytopenia, and microvascular thrombi that cause end-organ damage. The most prominent diagnoses associated with TMA are thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS). Although TTP and HUS can have similar clinical and laboratory features and are often lumped together as a combined entity referred to as \u201cTTP\/HUS,\u201d the pathologic processes causing TMA and optimal therapies for these conditions are different. Empiric use of therapeutic plasma exchange (TPE) in the setting of TMA is common. The high risk of morbidity and mortality associated with some causes of TMA justify rapid institution of this relatively low-risk procedure. However, many causes of TMA do not respond to TPE and prolonged courses of exchange in the absence of an underlying diagnosis may cause a detrimental delay in appropriate medical therapy. The American Society of Apheresis has published guidelines for the use of TPE for several distinct conditions associated with TMA. This list is not comprehensive and the use of TPE for other causes of TMA may be considered if the mechanism of the underlying disease process provides a clear rationale for this intervention.<\/jats:p>","DOI":"10.1182\/asheducation-2014.1.444","type":"journal-article","created":{"date-parts":[[2014,11,24]],"date-time":"2014-11-24T18:39:03Z","timestamp":1416854343000},"page":"444-449","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":32,"title":["Thrombotic microangiopathy and indications for therapeutic plasma exchange"],"prefix":"10.1182","volume":"2014","author":[{"given":"Jill","family":"Adamski","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, Phoenix, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"issue":"2","key":"2019111702525020400_B1","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.semnephrol.2012.02.007","article-title":"Endothelial cells and thrombotic microangiopathy","volume":"32","author":"Motto","year":"2012","journal-title":"Semin Nephrol"},{"issue":"3","key":"2019111702525020400_B2","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/j.1365-2141.2012.09167.x","article-title":"Guidelines on the diagnosis and management of thrombotic thrombocytopenic purpura and other thrombotic microangiopathies","volume":"158","author":"Scully","year":"2012","journal-title":"Br J Haematol"},{"issue":"2","key":"2019111702525020400_B3","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1055\/s-0032-1333538","article-title":"Evaluation of patients with microangiopathic hemolytic anemia and thrombocytopenia","volume":"39","author":"George","year":"2013","journal-title":"Semin Thromb Hemost"},{"issue":"5","key":"2019111702525020400_B4","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/j.1744-9987.2005.00319.x","article-title":"Complications of therapeutic plasma exchange: experience with 4857 treatments","volume":"9","author":"Basic-Jukic","year":"2005","journal-title":"Ther Apher Dial"},{"issue":"4","key":"2019111702525020400_B5","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/bjh.12569","article-title":"Role of ADAMTS13 in the management of thrombotic microangiopathies including thrombotic thrombocytopenic purpura (TTP)","volume":"163","author":"Shah","year":"2013","journal-title":"Br J Haematol"},{"issue":"3","key":"2019111702525020400_B6","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/jca.21276","article-title":"Guidelines on the use of therapeutic apheresis in clinical practice-evidence-based approach from the Writing Committee of the American Society for Apheresis: the sixth special issue","volume":"28","author":"Schwartz","year":"2013","journal-title":"J Clin Apher"},{"issue":"7","key":"2019111702525020400_B7","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1111\/j.1538-7836.2005.01436.x","article-title":"The incidence of thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: all patients, idiopathic patients, and patients with severe ADAMTS-13 deficiency","volume":"3","author":"Terrell","year":"2005","journal-title":"J Thromb Haemost"},{"issue":"6","key":"2019111702525020400_B8","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1056\/NEJM199108083250604","article-title":"Comparison of plasma exchange with plasma infusion in the treatment of thrombotic thrombocytopenic purpura. 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