{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T08:59:49Z","timestamp":1793177989266,"version":"4.5.0"},"reference-count":43,"publisher":"American Society of Hematology","issue":"1","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,12,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hemolytic disease of the fetus and newborn (HDFN) affects 3\/100 000 to 80\/100 000 patients per year. It is due to maternal blood group antibodies that cause fetal red cell destruction and in some cases, marrow suppression. This process leads to fetal anemia, and in severe cases can progress to edema, ascites, heart failure, and death. Infants affected with HDFN can have hyperbilirubinemia in the acute phase and hyporegenerative anemia for weeks to months after birth. The diagnosis and management of pregnant women with HDFN is based on laboratory and radiographic monitoring. Fetuses with marked anemia may require intervention with intrauterine transfusion. HDFN due to RhD can be prevented by RhIg administration. Prevention for other causal blood group specificities is less studied.<\/jats:p>","DOI":"10.1182\/asheducation-2015.1.146","type":"journal-article","created":{"date-parts":[[2016,9,15]],"date-time":"2016-09-15T11:23:25Z","timestamp":1473938605000},"page":"146-151","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":126,"title":["Hemolytic disease of the fetus and newborn: managing the mother, fetus, and newborn"],"prefix":"10.1182","volume":"2015","author":[{"given":"Meghan","family":"Delaney","sequence":"first","affiliation":[{"name":"Seattle Children's Hospital, Seattle, WA;"},{"name":"University of Washington, Seattle, WA; and"},{"name":"Bloodworks NW, Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana C.","family":"Matthews","sequence":"additional","affiliation":[{"name":"Seattle Children's Hospital, Seattle, WA;"},{"name":"University of Washington, Seattle, WA; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"key":"2019111706372290000_B1","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1053\/j.semperi.2011.02.009","article-title":"Diagnostic laboratory technologies for the fetus and neonate with isoimmunization","volume":"35","author":"Geaghan","year":"2011","journal-title":"Semin Perinatol"},{"key":"2019111706372290000_B2","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/S0029-7844(96)00434-6","article-title":"Female alloimmunization with antibodies known to cause hemolytic disease","volume":"89","author":"Geifman-Holtzman","year":"1997","journal-title":"Obstet Ggynecol"},{"key":"2019111706372290000_B3","article-title":"Detection and prevention of of pregnancy immunisation - The OPZI study","author":"Koelewijn","year":"2009"},{"key":"2019111706372290000_B4","volume-title":"Technical Manual","author":"American Assocation of Blood Banks","year":"2014","edition":"Ed 18"},{"key":"2019111706372290000_B5","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1093\/intimm\/13.8.993","article-title":"The MHC class I-related receptor, FcRn, plays an essential role in the maternofetal transfer of gamma-globulin in humans","volume":"13","author":"Firan","year":"2001","journal-title":"Int Immunol"},{"key":"2019111706372290000_B6","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1056\/NEJM200102223440807","article-title":"Neonatal hyperbilirubinemia","volume":"344","author":"Dennery","year":"2001","journal-title":"N Engl J Med"},{"key":"2019111706372290000_B7","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1093\/ije\/dyu079","article-title":"Associations of Rhesus and non-Rhesus maternal red blood cell alloimmunization with stillbirth and preterm birth","volume":"43","author":"Fan","year":"2014","journal-title":"Int J Epidemiol"},{"key":"2019111706372290000_B8","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.earlhumdev.2011.07.010","article-title":"Hematological morbidity and management in neonates with hemolytic disease due to red cell alloimmunization","volume":"87","author":"Rath","year":"2011","journal-title":"Early Hum Dev"},{"key":"2019111706372290000_B9","doi-asserted-by":"crossref","first-page":"e95","DOI":"10.1097\/MPH.0b013e3181cf444c","article-title":"Recombinant human erythropoietin in the prevention of late anemia in intrauterine transfused neonates with Rh-isoimmunization","volume":"32","author":"Zuppa","year":"2010","journal-title":"J Pediatr Hematol Oncol"},{"key":"2019111706372290000_B10","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1046\/j.1537-2995.1990.30490273444.x","article-title":"Fetomaternal hemorrhage: incidence, risk factors, time of occurrence, and clinical effects","volume":"30","author":"Sebring","year":"1990","journal-title":"Transfusion"},{"key":"2019111706372290000_B11","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1159\/000368995","article-title":"Factors Influencing RBC Alloimmunization: Lessons Learned from Murine Models","volume":"41","author":"Ryder","year":"2014","journal-title":"Transfus Med Hemother"},{"key":"2019111706372290000_B12","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1111\/j.1537-2995.2008.01800.x","article-title":"Prevention of D sensitization after mismatched transfusion of blood components: toward optimal use of RhIG","volume":"48","author":"Ayache","year":"2008","journal-title":"Transfusion"},{"key":"2019111706372290000_B13","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0002-9378(85)90288-1","article-title":"Controversies in Rh prophylaxis. Who needs Rh immune globulin and when should it be given?","volume":"151","author":"Bowman","year":"1985","journal-title":"Am J Obstet Gynecol"},{"key":"2019111706372290000_B14","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1111\/j.1471-0528.2008.01984.x","article-title":"Risk factors for the presence of non-rhesus D red blood cell antibodies in pregnancy","volume":"116","author":"Koelewijn","year":"2009","journal-title":"BJOG"},{"key":"2019111706372290000_B15","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1111\/j.1537-2995.2007.01626.x","article-title":"Implementation of routine screening for Kell antibodies: does it improve perinatal survival?","volume":"48","author":"Kamphuis","year":"2008","journal-title":"Transfusion"},{"key":"2019111706372290000_B16","doi-asserted-by":"crossref","first-page":"3662","DOI":"10.1182\/blood.V95.12.3662","article-title":"RHD gene deletion occurred in the Rhesus box","volume":"95","author":"Wagner","year":"2000","journal-title":"Blood"},{"key":"2019111706372290000_B17","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1111\/j.1537-2995.2007.01437.x","article-title":"Fetal genotyping for the K (Kell) and Rh C, c, and E blood groups on cell-free fetal DNA in maternal plasma","volume":"47","author":"Finning","year":"2007","journal-title":"Transfusion"},{"key":"2019111706372290000_B18","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/pd.2172","article-title":"Noninvasive prenatal diagnosis of fetal blood group phenotypes: current practice and future prospects","volume":"29","author":"Daniels","year":"2009","journal-title":"Prenat Diagn"},{"key":"2019111706372290000_B19","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1097\/AOG.0b013e31826d7dc1","article-title":"Management and prevention of red cell alloimmunization in pregnancy: a systematic review","volume":"120","author":"Moise","year":"2012","journal-title":"Obstet Gynecol"},{"key":"2019111706372290000_B20","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1365-3148.1995.tb00228.x","article-title":"Red cell antibodies in pregnancy: there is no \u201ccritical titre\u201d","volume":"5","author":"van Dijk","year":"1995","journal-title":"Trans Med"},{"key":"2019111706372290000_B21","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.5858\/2008-132-1194-RTVIPO","article-title":"Reducing the variation in performance of antibody titrations","volume":"132","author":"AuBuchon","year":"2008","journal-title":"Arch Pathol Lab Med"},{"key":"2019111706372290000_B22","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1056\/NEJM199803193381204","article-title":"Inhibition of erythroid progenitor cells by anti-Kell antibodies in fetal alloimmune anemia","volume":"338","author":"Vaughan","year":"1998","journal-title":"N Engl J Med"},{"key":"2019111706372290000_B23","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1046\/j.1423-0410.1997.7230172.x","article-title":"Flow-cytometric quantitation of anti-D antibodies","volume":"72","author":"Hilden","year":"1997","journal-title":"Vox Sanguinis"},{"key":"2019111706372290000_B24","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1097\/00006250-200608000-00044","article-title":"ACOG Practice Bulletin No. 75: Management of alloimmunization during pregnancy","volume":"108","year":"2006","journal-title":"Obstet Gynecol"},{"key":"2019111706372290000_B25","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1046\/j.1537-2995.1994.341195065035.x","article-title":"Induction of additional red cell alloantibodies after intrauterine transfusions","volume":"34","author":"Vietor","year":"1994","journal-title":"Transfusion"},{"key":"2019111706372290000_B26","doi-asserted-by":"crossref","first-page":"143.e141","DOI":"10.1016\/j.ajog.2006.10.895","article-title":"High additional maternal red cell alloimmunization after Rhesus- and K-matched intrauterine intravascular transfusions for hemolytic disease of the fetus","volume":"196","author":"Schonewille","year":"2007","journal-title":"Am J Obstet Gynecol"},{"key":"2019111706372290000_B27","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1111\/j.1471-0528.1997.tb12026.x","article-title":"The disappearance of fetal and donor red blood cells in alloimmunised pregnancies: a reappraisal","volume":"104","author":"Egberts","year":"1997","journal-title":"Br J Obstet Gynecol"},{"key":"2019111706372290000_B28","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1111\/j.0001-6349.2004.00394.x","article-title":"Treatment of fetal anemia due to red-cell alloimmunization with intrauterine transfusions in the Netherlands, 1988-1999","volume":"83","author":"van Kamp","year":"2004","journal-title":"Acta Obstet Gynecol Scand"},{"key":"2019111706372290000_B29","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ajog.2004.06.063","article-title":"Complications of intrauterine intravascular transfusion for fetal anemia due to maternal red-cell alloimmunization","volume":"192","author":"Van Kamp","year":"2005","journal-title":"Am J Obstet Gynecol"},{"key":"2019111706372290000_B30","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1097\/00006250-199203000-00013","article-title":"The severely anemic and hydropic isoimmune fetus: changes in fetal hematocrit associated with intrauterine death","volume":"79","author":"Radunovic","year":"1992","journal-title":"Obstet Gynecol"},{"key":"2019111706372290000_B31","doi-asserted-by":"crossref","first-page":"138.e131","DOI":"10.1016\/j.ajog.2006.10.890","article-title":"Combined plasmapheresis and intravenous immune globulin for the treatment of severe maternal red cell alloimmunization","volume":"196","author":"Ruma","year":"2007","journal-title":"Am J Obstet Gynecol"},{"key":"2019111706372290000_B32","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/jca.21276","article-title":"Guidelines on the use of therapeutic apheresis in clinical practice-evidence-based approach from the Writing Committee of the American Society for Apheresis: the sixth special issue","volume":"28","author":"Schwartz","year":"2013","journal-title":"J Clin Apheresis"},{"key":"2019111706372290000_B33","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1542\/peds.114.1.297","article-title":"Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation","volume":"114","author":"American Academy of Pediatrics Subcommittee on Hyperbilirubinemia","year":"2004","journal-title":"Pediatrics"},{"key":"2019111706372290000_B34","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1111\/j.1537-2995.2007.01625.x","article-title":"Effect of screening for red cell antibodies, other than anti-D, to detect hemolytic disease of the fetus and newborn: a population study in the Netherlands","volume":"48","author":"Koelewijn","year":"2008","journal-title":"Transfusion"},{"key":"2019111706372290000_B35","first-page":"528","article-title":"Relationship between previous maternal transfusions and haemolytic disease of the foetus and newborn mediated by non-RhD antibodies","volume":"11","author":"Dajak","year":"2013","journal-title":"Blood Transfus"},{"key":"2019111706372290000_B36","first-page":"63","article-title":"Prevention of Rh D alloimmunization. Number 4, May 1999 (replaces educational bulletin Number 147, October 1990): clinical management guidelines for obstetrician-gynecologists. American College of Obstetrics and Gynecology","volume":"66","author":"ACOG practice bulletin","year":"1999","journal-title":"Int J Gynaecol Obstet"},{"key":"2019111706372290000_B37","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1111\/trf.12130","article-title":"Proficiency tests reveal the need to improve laboratory assays for fetomaternal hemorrhage for Rh immunoprophylaxis","volume":"53","author":"Sandler","year":"2013","journal-title":"Transfusion"},{"key":"2019111706372290000_B38","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1097\/01.moh.0000245694.70135.c3","article-title":"How I manage donors and patients with a weak D phenotype","volume":"13","author":"Flegel","year":"2006","journal-title":"Curr Opin Hematol"},{"key":"2019111706372290000_B39","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1111\/trf.12941","article-title":"It's time to phase in RHD genotyping for patients with a serologic weak D phenotype","volume":"55","author":"Sandler","year":"2015","journal-title":"Transfusion"},{"key":"2019111706372290000_B40","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1111\/j.1471-0528.2009.02244.x","article-title":"Risk factors for RhD immunisation despite antenatal and postnatal anti-D prophylaxis","volume":"116","author":"Koelewijn","year":"2009","journal-title":"BJOG"},{"key":"2019111706372290000_B41","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.tmrv.2006.08.003","article-title":"Blood group antibodies and their significance in transfusion medicine","volume":"21","author":"Poole","year":"2007","journal-title":"Transfus Med Rev"},{"key":"2019111706372290000_B42","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.siny.2008.02.007","article-title":"Fetal anemia due to non-Rhesus-D red-cell alloimmunization","volume":"13","author":"Moise","year":"2008","journal-title":"Semin Fetal Neonatal Med"},{"key":"2019111706372290000_B43","doi-asserted-by":"crossref","first-page":"687","DOI":"10.3109\/00016349509021175","article-title":"The prevalence of red cell antibodies in pregnancy correlated to the outcome of the newborn: a 12 year study in central Sweden","volume":"74","author":"Filbey","year":"1995","journal-title":"Acta Obstet Gynecol Scand"}],"container-title":["Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/ashpublications.org\/hematology\/article-pdf\/2015\/1\/146\/1251253\/bep00115000146.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/ashpublications.org\/hematology\/article-pdf\/2015\/1\/146\/1251253\/bep00115000146.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T11:27:46Z","timestamp":1657279666000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/hematology\/article\/2015\/1\/146\/20756\/Hemolytic-disease-of-the-fetus-and-newborn"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,5]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12,5]]}},"URL":"https:\/\/doi.org\/10.1182\/asheducation-2015.1.146","relation":{},"ISSN":["1520-4391","1520-4383"],"issn-type":[{"value":"1520-4391","type":"print"},{"value":"1520-4383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,5]]}}}