{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T02:10:01Z","timestamp":1793067001094,"version":"4.5.0"},"reference-count":54,"publisher":"American Society of Hematology","issue":"1","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,12,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Iron deficiency is the commonest cause of anemia during pregnancy; however, its prevalence is highly determined by nutritional and socioeconomic status. Oral iron is the frontline therapy, but is often poorly tolerated. Awareness of the available intravenous formulations is essential for management. Before delivery, risk factors such as multiparity and heavy uterine bleeding increase the prevalence of iron deficiency and should be motivation for early diagnosis and treatment. Neonates born with iron deficiency have a statistically significant increment in both cognitive and behavioral abnormalities that persist after repletion, highlighting the need for heightened awareness of the diagnosis. A smartphone application providing information on nutrition and treatment is provided. New formulations of intravenous iron with carbohydrate cores, which bind elemental iron more tightly, minimize the release of labile free iron to allow complete replacement doses of intravenous iron in 15 to 60 minutes, facilitating and simplifying care.<\/jats:p>","DOI":"10.1182\/asheducation-2017.1.152","type":"journal-article","created":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T22:13:11Z","timestamp":1555452791000},"page":"152-159","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":81,"title":["Iron deficiency in gynecology and obstetrics: clinical implications and management"],"prefix":"10.1182","volume":"2017","author":[{"given":"Christian","family":"Breymann","sequence":"first","affiliation":[{"name":"Obstetric Research\u2013Feto Maternal Hematology Unit, University Hospital Zurich, Zurich, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Auerbach","sequence":"additional","affiliation":[{"name":"Department of Medicine, Georgetown University School of Medicine, Washington, DC; and"},{"name":"Auerbach Hematology and Oncology, Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"issue":"4","key":"2019111706060184300_B1","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s00277-010-1144-5","article-title":"Anemia--still a major health problem in many parts of the world!","volume":"90","author":"Milman","year":"2011","journal-title":"Ann Hematol"},{"issue":"5","key":"2019111706060184300_B2","doi-asserted-by":"crossref","first-page":"1246S","DOI":"10.1093\/ajcn\/81.5.1246","article-title":"Micronutrient requirements of physically active women: what can we learn from iron?","volume":"81","author":"Akabas","year":"2005","journal-title":"Am J Clin Nutr"},{"issue":"3","key":"2019111706060184300_B3","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.ijgo.2014.09.027","article-title":"Prevalence of heavy menstrual bleeding and experiences of affected women in a European patient survey","volume":"128","author":"Fraser","year":"2015","journal-title":"Int J Gynaecol Obstet"},{"issue":"11","key":"2019111706060184300_B4","first-page":"822","article-title":"Menstrual blood loss and hematologic indices in healthy Chinese women","volume":"32","author":"Gao","year":"1987","journal-title":"J Reprod Med"},{"issue":"4","key":"2019111706060184300_B5","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1753-4887.1997.tb06460.x","article-title":"Pregnancy and iron deficiency: unresolved issues","volume":"55","author":"Allen","year":"1997","journal-title":"Nutr Rev"},{"issue":"6","key":"2019111706060184300_B6","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.ejim.2012.04.008","article-title":"Anemia--prevalence and risk factors in pregnancy","volume":"23","author":"Bencaiova","year":"2012","journal-title":"Eur J Intern Med"},{"issue":"2","key":"2019111706060184300_B7","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1515\/jpm.2010.132","article-title":"Expert recommendations for the diagnosis and treatment of iron-deficiency anemia during pregnancy and the postpartum period in the Asia-Pacific region","volume":"39","author":"Breymann","year":"2011","journal-title":"J Perinat Med"},{"issue":"2B","key":"2019111706060184300_B8","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1079\/PHN2001139","article-title":"Iron deficiency in Europe","volume":"4","author":"Hercberg","year":"2001","journal-title":"Public Health Nutr"},{"issue":"4","key":"2019111706060184300_B9","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1136\/jcp.2010.086991","article-title":"Disorders of iron metabolism. 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