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Nonmalignant cell recruitment and plasticity are dictated by lymphoma B cells, which convert their surrounding microenvironment into a supportive niche. In addition, they are also influenced by the crosstalk between the various components of this niche. In agreement with this, the B-cell lymphoma subtype is a key determinant of the organization of the tumor niche, but genetic alteration patterns, tumor localization, stage of the disease, and treatment strategy may also modulate its composition and activity. Moreover, the complex set of bidirectional interactions between B cells and their microenvironment has been proposed as a promising therapeutic target with the aim of reinforcing antitumor immunity and\/or of abbrogating the lymphoma-promoting signals delivered by the tumor niche.<\/jats:p>","DOI":"10.1182\/asheducation-2017.1.610","type":"journal-article","created":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T22:13:11Z","timestamp":1555452791000},"page":"610-617","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":33,"title":["Role of the microenvironment across histological subtypes of NHL"],"prefix":"10.1182","volume":"2017","author":[{"given":"Karin","family":"Tarte","sequence":"first","affiliation":[{"name":"UMR U1236, INSERM, Universit\u00e9 de Rennes 1, Etablissement fran\u00e7ais du sang (EFS) Bretagne, Equipe Labellis\u00e9e Ligue Contre le Cancer, Rennes, France; and"},{"name":"Laboratoire Suivi Immunologique des 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