{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T05:09:45Z","timestamp":1769231385231,"version":"3.49.0"},"reference-count":40,"publisher":"American Society of Hematology","issue":"1","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,12,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Postthrombotic syndrome (PTS) is a frequent complication of lower-extremity deep vein thrombosis (DVT), occurring in approximately 40% of patients despite the use of anticoagulant therapy. PTS causes significant impairment of patients\u2019 health-related quality of life, and no evidence-based therapies have been consistently effective. Catheter-directed thrombolysis and thrombectomy have been shown to remove acute thrombus, and it has been hypothesized they could prevent or reduce PTS. However, because these procedures can be associated with complications, mainly bleeding, randomized trial data are needed to determine when they should be used. In this article, I summarize the current status of thrombus removal procedures for DVT to provide contemporary guidance to clinicians seeking to individualize treatment decisions for their patients.<\/jats:p>","DOI":"10.1182\/asheducation-2017.1.681","type":"journal-article","created":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T18:13:11Z","timestamp":1555438391000},"page":"681-685","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":8,"title":["Thrombectomy and thrombolysis for the prevention and treatment of postthrombotic syndrome"],"prefix":"10.1182","volume":"2017","author":[{"given":"Suresh","family":"Vedantham","sequence":"first","affiliation":[{"name":"Interventional Radiology Section, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"234","reference":[{"issue":"10","key":"2019111703151521900_B1","doi-asserted-by":"crossref","first-page":"698","DOI":"10.7326\/0003-4819-149-10-200811180-00004","article-title":"Determinants and time course of the postthrombotic syndrome after acute deep venous thrombosis","volume":"149","author":"Kahn","year":"2008","journal-title":"Ann Intern Med"},{"issue":"7","key":"2019111703151521900_B2","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1111\/j.1538-7836.2008.03002.x","article-title":"Determinants of health-related quality of life during the 2 years following deep vein thrombosis","volume":"6","author":"Kahn","year":"2008","journal-title":"J Thromb Haemost"},{"issue":"2","key":"2019111703151521900_B3","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1148\/radiology.191.2.8153327","article-title":"Iliofemoral deep venous thrombosis: aggressive therapy with catheter-directed thrombolysis","volume":"191","author":"Semba","year":"1994","journal-title":"Radiology"},{"issue":"12","key":"2019111703151521900_B4","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1002\/bjs.1800661203","article-title":"A comparative randomized trial of heparin versus streptokinase in the treatment of acute proximal venous thrombosis: an interim report of a prospective trial","volume":"66","author":"Elliot","year":"1979","journal-title":"Br J Surg"},{"issue":"1-2","key":"2019111703151521900_B5","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.0954-6820.1982.tb01904.x","article-title":"Streptokinase of heparin in the treatment of deep vein thrombosis. 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