{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:17:12Z","timestamp":1791217032907,"version":"4.1.0"},"reference-count":19,"publisher":"American Society of Hematology","issue":"1","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2004,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A new World Health Organization classification was recently proposed. However, classification of peripheral T-cell lymphomas remains to be clarified. Particularly, unspecified type was considered as a heterogeneous category. Here we studied the expressions of chemokine receptors, Th1-associated CXCR3 and CCR5 and Th2-associated marker ST2(L), and activated T-cell receptor OX40\/CD134 in 185 patients with nodal T-cell lymphoma, and evaluated the relationship to prognosis. Their expression patterns correlated with the specific subtype of nodal T-cell lymphoma, such as angioimmunoblastic T-cell lymphoma (AILD), anaplastic large cell lymphoma (ALCL), and in peripheral T-cell lymphoma (PTCL), unspecified. In AILD, almost all cases were immunoreactive for OX40\/CD134 (96%) and for CXCR3 (89%). In ALCL, all cases were immunonegative for OX40\/CD134, and only a few cases (24%) were immunoreactive for CXCR3, whereas almost all cases (94%) were positive for ST2(L). Cases of PTCL, unspecified, were divided into 2 groups; group 1 (cases positive for either ST2(L), CCR5, or CXCR3) tended to show favorable prognosis compared with group 2 (cases negative for ST2(L), CCR5, and CXCR3). Our results indicate that further subtyping of PTCL, unspecified, into groups 1 and 2 could be significant for evaluating prognosis and understanding the functional role of these tumors.<\/jats:p>","DOI":"10.1182\/blood-2002-05-1352","type":"journal-article","created":{"date-parts":[[2003,9,8]],"date-time":"2003-09-08T22:21:21Z","timestamp":1063059681000},"page":"236-241","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":83,"title":["Th1, Th2, and activated T-cell marker and clinical prognosis in peripheral T-cell lymphoma, unspecified: comparison with AILD, ALCL, lymphoblastic lymphoma, and ATLL"],"prefix":"10.1182","volume":"103","author":[{"given":"Takeshi","family":"Tsuchiya","sequence":"first","affiliation":[{"name":"From the Departments of Pathology and Internal Medicine, School of Medicine, Fukuoka University, Japan; and Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Ohshima","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology and Internal Medicine, School of Medicine, Fukuoka University, Japan; and Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kennosuke","family":"Karube","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology and Internal Medicine, School of Medicine, Fukuoka University, Japan; and Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology and Internal Medicine, School of Medicine, Fukuoka University, Japan; and Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Suefuji","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology and Internal Medicine, School of Medicine, Fukuoka University, Japan; and Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Hamasaki","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology and Internal Medicine, School of Medicine, Fukuoka University, Japan; and Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chika","family":"Kawasaki","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology and Internal Medicine, School of Medicine, Fukuoka University, Japan; and Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junji","family":"Suzumiya","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology and Internal Medicine, School of Medicine, Fukuoka University, Japan; and Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Tomonaga","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology and Internal Medicine, School of Medicine, Fukuoka University, Japan; and Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology and Internal Medicine, School of Medicine, Fukuoka University, Japan; and Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"key":"2020021222510895000_REF1","doi-asserted-by":"crossref","unstructured":"Ohshima K, Suzumiya J, Sato K, et al. 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