{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:29:02Z","timestamp":1791088142596,"version":"4.1.0"},"reference-count":22,"publisher":"American Society of Hematology","issue":"3","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2003,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The signals that mediate T-cell infiltration during T-cell autoimmune diseases are poorly understood. The chemokine CCL21 (originally isolated by us and others as Exodus-2\/6Ckine\/SLC\/TCA4) is highly potent and highly specific for stimulating T-cell migration. However, it is thought to be expressed only in secondary lymphoid organs, directing naive T cells to areas of antigen presentation. It is not thought to play a role in T-cell effector function during a normal immune response. In this study we tested the expression of T-cell chemokines and their receptors during T-cell autoimmune infiltrative skin diseases. By using immunohistology it was found that the expression of CCL21 but not CCL19 or 20 was highly induced in endothelial cells of T-cell autoimmune diseases. The receptor for CCL21, CCR7, was also found to be highly expressed on the infiltrating T cells, most of which expressed the memory CD45Ro phenotype. These data imply that the usual loss of CCL21 responsiveness in the normal development of memory T-cell effector function does not hold for autoimmune skin diseases.<\/jats:p>","DOI":"10.1182\/blood-2002-05-1586","type":"journal-article","created":{"date-parts":[[2003,1,15]],"date-time":"2003-01-15T21:05:10Z","timestamp":1042664710000},"page":"801-806","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":50,"title":["Endothelial induction of the T-cell chemokine CCL21 in T-cell autoimmune diseases"],"prefix":"10.1182","volume":"101","author":[{"suffix":"II","given":"Kent W.","family":"Christopherson","sequence":"first","affiliation":[{"name":"From the Department of Microbiology and Immunology and the Walther Oncology Center, Department of Dermatology and the Wells Center for Pediatric Research, Division of Hematology\/Oncology and Walther Oncology Center, Indiana University Medical Center, Indianapolis."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoinette F.","family":"Hood","sequence":"additional","affiliation":[{"name":"From the Department of Microbiology and Immunology and the Walther Oncology Center, Department of Dermatology and the Wells Center for Pediatric Research, Division of Hematology\/Oncology and Walther Oncology Center, Indiana University Medical Center, Indianapolis."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey B.","family":"Travers","sequence":"additional","affiliation":[{"name":"From the Department of Microbiology and Immunology and the Walther Oncology Center, Department of Dermatology and the Wells Center for Pediatric Research, Division of Hematology\/Oncology and Walther Oncology Center, Indiana University Medical Center, Indianapolis."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Ramsey","sequence":"additional","affiliation":[{"name":"From the Department of Microbiology and Immunology and the Walther Oncology Center, Department of Dermatology and the Wells Center for Pediatric Research, Division of Hematology\/Oncology and Walther Oncology Center, Indiana University Medical Center, Indianapolis."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Hromas","sequence":"additional","affiliation":[{"name":"From the Department of Microbiology and Immunology and the Walther Oncology Center, Department of Dermatology and the Wells Center for Pediatric Research, Division of Hematology\/Oncology and Walther Oncology Center, Indiana University Medical Center, Indianapolis."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"key":"2019111615571427300_B1","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/33340","article-title":"Chemokines and leukocyte 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