{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T09:26:13Z","timestamp":1789032373141,"version":"build-2803163510"},"reference-count":41,"publisher":"American Society of Hematology","issue":"9","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2003,5,1]]},"abstract":"<jats:p>The importance of \u03b1\u03b2 versus \u03b3\u03b4 T-cell subset antigen expression in the classification of peripheral T-cell lymphomas is still unclear. The objective of this study was to investigate the prognostic value of T-cell receptor\u2013\u03b41 (TCR\u03b41) expression in primary cutaneous T-cell lymphomas. TCR\u03b41 cellular expression was assessed in skin biopsy specimens of 104 individuals with cutaneous T-cell lymphoma by immunohistochemistry. Both univariate (Kaplan-Meier) and multivariate (Cox regression) analyses were conducted to determine which variables (T-cell subtype, hemophagocytosis, histologic profile, age, sex, and adenopathy) were significantly associated with survival. Univariate analysis indicated that there was a statistically significant difference in survival between the patients with \u03b1\u03b2 cutaneous T-cell lymphoma and patients with \u03b3\u03b4 cutaneous T-cell lymphoma (P\u2009&lt;\u2009.0001). There was also a statistically significant decrease in survival among patients who had subcutaneous involvement compared with patients who had epidermotropic and\/or dermal involvement (P\u2009&lt;\u2009.0001). Cox model analysis indicated that TCR\u03b41 expression was the factor that was most closely associated with decreased survival (P\u2009&lt;\u2009.0001). Among those patients with cutaneous \u03b3\u03b4 T-cell lymphoma (n\u2009=\u200933), there was a trend for decreased survival for patients who had histologic evidence of subcutaneous fat involvement in comparison with patients who had epidermotropic or dermal patterns of infiltration (P\u2009=\u2009.067). No other prognostic factors were identified as having a notable association with outcome in this subgroup. TCR\u03b41 expression in primary cutaneous lymphomas is an independent prognostic factor associated with decreased survival.<\/jats:p>","DOI":"10.1182\/blood-2002-05-1597","type":"journal-article","created":{"date-parts":[[2003,4,21]],"date-time":"2003-04-21T17:30:06Z","timestamp":1050946206000},"page":"3407-3412","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":257,"title":["Gamma-delta T-cell phenotype is associated with significantly decreased survival in cutaneous T-cell lymphoma"],"prefix":"10.1182","volume":"101","author":[{"given":"Jorge R.","family":"Toro","sequence":"first","affiliation":[{"name":"From the Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics; the Biostatistics and Data Management Section, Center for Cancer Reseach; the Hematopathology Section; and the Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Liewehr","sequence":"additional","affiliation":[{"name":"From the Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics; the Biostatistics and Data Management Section, Center for Cancer Reseach; the Hematopathology Section; and the Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Pabby","sequence":"additional","affiliation":[{"name":"From the Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics; the Biostatistics and Data Management Section, Center for Cancer Reseach; the Hematopathology Section; and the Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Sorbara","sequence":"additional","affiliation":[{"name":"From the Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics; the Biostatistics and Data Management Section, Center for Cancer Reseach; the Hematopathology Section; and the Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Raffeld","sequence":"additional","affiliation":[{"name":"From the Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics; the Biostatistics and Data Management Section, Center for Cancer Reseach; the Hematopathology Section; and the Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth 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