{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T12:13:58Z","timestamp":1793708038086,"version":"4.6.1"},"reference-count":51,"publisher":"American Society of Hematology","issue":"4","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2003,2,15]]},"abstract":"<jats:p>This study analyzed the frequency and clinical significance of t(4;14)(p16;q32) in multiple myeloma (MM) among 208 patients with MM and 52 patients with monoclonal gammopathy of undetermined significance (MGUS); diagnosed between 1994 and 2001. Patients with the translocation were identified using reverse transcription\u2013polymerase chain reaction (RT-PCR) to detect hybrid immunoglobulin heavy chain (IgH)\u2013MMSET transcripts from the der(4) chromosome. We found 31 (14.9%) t(4;14)+ MM patients and 1 (1.9%) t(4;14)+ MGUS patient. IgH-MMSET hybrid transcripts were detected in bone marrow (BM) and blood. Breakpoint analysis revealed that 67.7% of t(4;14)+ patients expressed hybrid transcripts potentially encoding full-length MMSET, whereas the remainder lacked one or more amino terminal exons. Expression of fibroblast growth factor receptor 3 (FGFR3), presumptively dysregulated on der(14), was detected by RT-PCR in only 23 of 31 (74%) patients with t(4;14)+ MM. Patients lacking FGFR3 expression also lacked detectable der(14) products. Longitudinal analysis of 53 MM patients with multiple BM and blood samples showed that, over time, BM from t(4;14)+ patients remained positive and that t(4;14)\u2212 patients did not acquire the translocation. IgH-MMSET hybrid transcripts and FGFR3 transcripts disappeared from blood during response to therapy. No correlation was observed between the occurrence of t(4;14) and known prognostic indicators. However, we find the t(4;14) translocation predicts for poor survival (P\u2009=\u2009.006; median, 644 days vs 1288 days; hazard ratio [HR], 2.0), even in FGFR3 nonexpressors (P\u2009=\u2009.003). The presence of t(4;14) is also predictive of poor response to first-line chemotherapy (P\u2009=\u2009.05). These results indicate a significant clinical impact of the t(4;14) translocation in MM that is independent of FGFR3 expression.<\/jats:p>","DOI":"10.1182\/blood-2002-06-1675","type":"journal-article","created":{"date-parts":[[2003,1,30]],"date-time":"2003-01-30T16:36:12Z","timestamp":1043944572000},"page":"1520-1529","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":337,"title":["In multiple myeloma, t(4;14)(p16;q32) is an adverse prognostic factor irrespective of FGFR3 expression"],"prefix":"10.1182","volume":"101","author":[{"given":"Jonathan J.","family":"Keats","sequence":"first","affiliation":[{"name":"From the Departments of Oncology and Medicine, University of Alberta and Cross Cancer Institute, Edmonton, Alberta, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Reiman","sequence":"additional","affiliation":[{"name":"From the Departments of Oncology and Medicine, University of Alberta and Cross Cancer Institute, Edmonton, Alberta, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher A.","family":"Maxwell","sequence":"additional","affiliation":[{"name":"From the Departments of Oncology and Medicine, University of Alberta and Cross Cancer Institute, Edmonton, Alberta, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian J.","family":"Taylor","sequence":"additional","affiliation":[{"name":"From the Departments of Oncology and Medicine, University of Alberta and Cross Cancer Institute, Edmonton, Alberta, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loree M.","family":"Larratt","sequence":"additional","affiliation":[{"name":"From the Departments of Oncology and Medicine, University of Alberta and Cross Cancer Institute, Edmonton, Alberta, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael 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