{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T16:50:41Z","timestamp":1761843041552},"reference-count":31,"publisher":"American Society of Hematology","issue":"3","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2003,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Transgenic mice have been generated that carry a CD45 minigene under control of the human leukocyte function-associated antigen (LFA-1, CD11a) promoter. CD45-null mice carrying the transgene exhibit the lymphocyte lineage-specific isoform expression patterns of wild-type mice. Furthermore, these mice have normal thymocyte development and peripheral T-cell numbers. The proliferative ability of T cells in response to mitogens and antigen also is regained, as is B-cell responsiveness to anti-IgM. The antibody response to antigen is also restored and is similar to that of normal mice. Therefore, introduction of a functional CD45 minigene is sufficient to overcome the principal severe combined immunodeficiency (SCID)\u2013associated defects and represents a potential route to a gene therapy for human CD45-deficent SCID.<\/jats:p>","DOI":"10.1182\/blood-2002-07-1969","type":"journal-article","created":{"date-parts":[[2003,1,15]],"date-time":"2003-01-15T21:05:10Z","timestamp":1042664710000},"page":"849-855","update-policy":"http:\/\/dx.doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":15,"title":["A CD45 minigene restores regulated isoform expression and immune function in CD45-deficient mice: therapeutic implications for human CD45-null severe combined immunodeficiency"],"prefix":"10.1182","volume":"101","author":[{"given":"Elizabeth L.","family":"Virts","sequence":"first","affiliation":[{"name":"From the Sidney Kimmel Cancer Center, San Diego, 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