{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:48:26Z","timestamp":1793393306236,"version":"4.5.0"},"reference-count":56,"publisher":"American Society of Hematology","issue":"8","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2003,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Selective serotonin reuptake inhibitors (SSRIs) are the treatment of choice for clinical depression and a range of anxiety-related disorders. They are well tolerated over extended periods with more than 50 million people worldwide benefiting from their use. Here we show that 3 structurally distinct SSRIs\u2014fluoxetine, paroxetine, and citalopram\u2014act directly on Burkitt lymphoma (BL) cells to trigger rapid and extensive programmed cell death. SSRIs unexpectedly stimulated calcium flux, tyrosine phosphorylation, and down-regulation of the c-myc and nm23 genes in Burkitt lymphoma cells remaining faithful to the biopsy phenotype. Resultant SSRI-induced apoptosis was preceded by caspase activation, poly(ADP-ribose) polymerase-1 (PARP-1) cleavage, DNA fragmentation, a loss of mitochondrial membrane potential, and the externalization of phosphatidylserine, and reversed by the overexpression of bcl-2. Normal peripheral blood mononuclear cells and tonsil B cells, whether resting or stimulated into cycle, were largely resistant to SSRI-induced death as were 5 non-BL lymphoid cell lines tested. We discuss these findings within the context of whether the SSRI class of antidepressants could find future application as potential therapeutics for the highly aggressive and\u2014because of its association with AIDS\u2014increasingly more common Burkitt lymphoma.<\/jats:p>","DOI":"10.1182\/blood-2002-07-2044","type":"journal-article","created":{"date-parts":[[2003,4,2]],"date-time":"2003-04-02T13:43:59Z","timestamp":1049291039000},"page":"3212-3219","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":144,"title":["Selective serotonin reuptake inhibitors directly signal for apoptosis in biopsy-like Burkitt lymphoma cells"],"prefix":"10.1182","volume":"101","author":[{"given":"Adamantios","family":"Serafeim","sequence":"first","affiliation":[{"name":"From the Medical Research Council (MRC) Centre for Immune Regulation, School of Biosciences, and Division of Neurosciences, The Medical School, University of Birmingham, Birmingham, United Kingdom; and the MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle J.","family":"Holder","sequence":"additional","affiliation":[{"name":"From the Medical Research Council (MRC) Centre for Immune Regulation, School of Biosciences, and Division of Neurosciences, The Medical School, University of Birmingham, Birmingham, United Kingdom; and the MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian","family":"Grafton","sequence":"additional","affiliation":[{"name":"From the Medical Research Council (MRC) Centre for Immune Regulation, School of Biosciences, and Division of Neurosciences, The Medical School, University of Birmingham, Birmingham, United Kingdom; and the MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Chamba","sequence":"additional","affiliation":[{"name":"From the Medical Research Council (MRC) Centre for Immune Regulation, School of Biosciences, and Division of Neurosciences, The Medical School, University of Birmingham, Birmingham, United Kingdom; and the MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark T.","family":"Drayson","sequence":"additional","affiliation":[{"name":"From the Medical Research Council (MRC) Centre for Immune Regulation, School of Biosciences, and Division of Neurosciences, The Medical School, University of Birmingham, Birmingham, United Kingdom; and the MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quang T.","family":"Luong","sequence":"additional","affiliation":[{"name":"From the Medical Research Council (MRC) Centre for Immune Regulation, School of Biosciences, and Division of Neurosciences, The Medical School, University of Birmingham, Birmingham, United Kingdom; and the MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M.","family":"Bunce","sequence":"additional","affiliation":[{"name":"From the Medical Research Council (MRC) Centre for Immune Regulation, School of Biosciences, and Division of Neurosciences, The Medical School, University of Birmingham, Birmingham, United Kingdom; and the MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.","family":"Gregory","sequence":"additional","affiliation":[{"name":"From the Medical Research Council (MRC) Centre for Immune Regulation, School of Biosciences, and Division of Neurosciences, The Medical School, University of Birmingham, Birmingham, United Kingdom; and the MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas M.","family":"Barnes","sequence":"additional","affiliation":[{"name":"From the Medical Research Council (MRC) Centre for Immune Regulation, School of Biosciences, and Division of Neurosciences, The Medical School, University of Birmingham, Birmingham, United Kingdom; and the MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Gordon","sequence":"additional","affiliation":[{"name":"From the Medical Research Council (MRC) Centre for Immune Regulation, School of Biosciences, and Division of Neurosciences, The Medical School, University of Birmingham, Birmingham, United Kingdom; and the MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"key":"2019111618274546100_B1","first-page":"601","article-title":"Histopathological definition of Burkitt's lymphoma.","volume":"40","author":"Berard","year":"1969","journal-title":"Bull WHO."},{"key":"2019111618274546100_B2","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/1097-0142(196103\/04)14:2<270::AID-CNCR2820140207>3.0.CO;2-Q","article-title":"Malignant lymphoma in African children: II. pathological entity.","volume":"14","author":"O'Conor","year":"1961","journal-title":"Cancer."},{"key":"2019111618274546100_B3","first-page":"40","article-title":"Management of high-grade lymphomas.","volume":"12","author":"Magrath","year":"1998","journal-title":"Oncology (Huntingt)."},{"key":"2019111618274546100_B4","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/(SICI)1097-0215(19971127)73:5<645::AID-IJC6>3.0.CO;2-X","article-title":"Non-Hodgkin's lymphoma among people with AIDS: incidence, presentation and public health burden. AIDS\/Cancer Study Group.","volume":"73","author":"Cote\u0301","year":"1997","journal-title":"Int J Cancer."},{"key":"2019111618274546100_B5","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1097\/00002030-199408000-00003","article-title":"Pathogenesis of AIDS lymphomas.","volume":"8","author":"Herndier","year":"1994","journal-title":"AIDS."},{"key":"2019111618274546100_B6","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3109\/10428190009053542","article-title":"Intensive chemotherapy (LNHIV-91 regimen) and G-CSF for HIV associated non-Hodgkin's lymphoma.","volume":"39","author":"Oksenhendler","year":"2000","journal-title":"Leuk Lymphoma."},{"key":"2019111618274546100_B7","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/0167-5699(85)90036-2","article-title":"Myc\/Ig juxtaposition by chromosomal translocations: some new insights, puzzles, and paradoxes.","volume":"6","author":"Klein","year":"1985","journal-title":"Immunol Today."},{"key":"2019111618274546100_B8","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/328445a0","article-title":"A c-myc antisense oligodeoxynucleotide inhibits entry into S-phase but not progress from G0 to G1.","volume":"328","author":"Heikkila","year":"1987","journal-title":"Nature."},{"key":"2019111618274546100_B9","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/S0959-437X(05)80339-9","article-title":"The role of c-myc in cell growth.","volume":"3","author":"Evan","year":"1993","journal-title":"Curr Opin Genet Dev."},{"key":"2019111618274546100_B10","doi-asserted-by":"crossref","first-page":"13392","DOI":"10.1074\/jbc.270.22.13392","article-title":"The transcription factor, Nm23H2, binds to and activates the translocated c-myc allele in Burkitt's lymphoma.","volume":"270","author":"Ji","year":"1995","journal-title":"J Biol Chem."},{"key":"2019111618274546100_B11","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1038\/sj.onc.1205259","article-title":"The N-myc and c-myc downstream pathways include the chromosome 17q genes nm23-H1 and nm23-H2.","volume":"21","author":"Godfried","year":"2002","journal-title":"Oncogene."},{"key":"2019111618274546100_B12","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1182\/blood.V97.5.1202","article-title":"Serum nm23-H1 protein as a prognostic factor in aggressive non-Hodgkin lymphoma.","volume":"97","author":"Niitsu","year":"2001","journal-title":"Blood."},{"key":"2019111618274546100_B13","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/bjc.1963.8","article-title":"Cellular degeneration associated with characteristic nuclear fine structure changes in the cells from two cases of Burkitt's malignant lymphoma syndrome.","volume":"17","author":"Epstein","year":"1963","journal-title":"Brit J Cancer."},{"key":"2019111618274546100_B14","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1093\/jnci\/77.3.681","article-title":"Endemic Burkitt's lymphoma: phenotypic analysis of tumour biopsy cells and of derived tumor cell lines.","volume":"77","author":"Rooney","year":"1986","journal-title":"J Natl Cancer Inst."},{"key":"2019111618274546100_B15","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/ijc.2910420212","article-title":"Isolation of a normal B cell subset with a Burkitt-like phenotype and transformation in vitro with Epstein-Barr virus.","volume":"42","author":"Gregory","year":"1988","journal-title":"Int J Cancer."},{"key":"2019111618274546100_B16","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1146\/annurev.iy.12.040194.001001","article-title":"Germinal centers.","volume":"12","author":"MacLennan","year":"1994","journal-title":"Annu Rev Immunol."},{"key":"2019111618274546100_B17","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1002\/eji.1830230948","article-title":"Suppression of apoptosis in normal and neoplastic human B lymphocytes by CD40 ligand is independent of Bcl-2 induction.","volume":"9","author":"Holder","year":"1993","journal-title":"Eur J Immunol."},{"key":"2019111618274546100_B18","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1099\/0022-1317-71-7-1481","article-title":"Different Epstein-Barr virus B cell interactions in phenotypically distinct clones of a Burkitt's lymphoma cell line.","volume":"71","author":"Gregory","year":"1990","journal-title":"J Gen Virol."},{"key":"2019111618274546100_B19","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1002\/j.1460-2075.1987.tb02568.x","article-title":"Differences in B cell growth phenotype reflect novel patterns of Epstein-Barr virus latent gene expression in Burkitt's lymphoma cells.","volume":"6","author":"Rowe","year":"1987","journal-title":"EMBO J."},{"key":"2019111618274546100_B20","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1182\/blood.V99.7.2545","article-title":"5-Hydroxytryptamine drives apoptosis in biopsylike Burkitt lymphoma cells: reversal by selective serotonin reuptake inhibitors.","volume":"99","author":"Serafeim","year":"2002","journal-title":"Blood."},{"key":"2019111618274546100_B21","doi-asserted-by":"crossref","first-page":"2830","DOI":"10.1182\/blood.V92.8.2830","article-title":"Prolonged phenotypic, functional, and molecular change in group I Burkitt lymphoma cells on short-term exposure to CD40 ligand.","volume":"92","author":"Baker","year":"1998","journal-title":"Blood."},{"key":"2019111618274546100_B22","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/sj.cdd.4400710","article-title":"CD40 Ligand, Bcl-2, and Bcl-xL spare Group I Burkitt lymphoma cells from CD77-directed killing via Verotoxin-1 B chain but fail to protect against the holotoxin.","volume":"7","author":"Gordon","year":"2000","journal-title":"Cell Death Diff."},{"key":"2019111618274546100_B23","doi-asserted-by":"crossref","first-page":"3236","DOI":"10.1002\/(SICI)1521-4141(199910)29:10<3236::AID-IMMU3236>3.0.CO;2-T","article-title":"The extrafollicular-to-follicular transition of human B lymphocytes: induction of functional globotriaosylceramide (CD77) on high threshold occupancy of CD40.","volume":"29","author":"McCloskey","year":"1999","journal-title":"Eur Jimmunol."},{"key":"2019111618274546100_B24","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1182\/blood.V87.3.1147.bloodjournal8731147","article-title":"Transforming growth factor-\u03b21 cooperates with anti-immunoglobulin for the induction of apoptosis in group I (biopsy-like) Burkitt lymphoma cell lines.","volume":"87","author":"MacDonald","year":"1996","journal-title":"Blood."},{"key":"2019111618274546100_B25","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/sj.cdd.4400945","article-title":"Induction of apoptosis by chemotherapeutic drugs: the role of FADD in activation of caspase-8 and synergy with death receptor ligands in ovarian carcinoma cells.","volume":"9","author":"Milner","year":"2002","journal-title":"Cell Death Differ."},{"key":"2019111618274546100_B26","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1182\/blood.V100.2.647","article-title":"Response of hairy cells to IFN-\u03b1 involves induction of apoptosis through autocrine TNF-\u03b1 and protection by adhesion.","volume":"100","author":"Baker","year":"2002","journal-title":"Blood."},{"key":"2019111618274546100_B27","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/349612a0","article-title":"Activation of Epstein-Barr virus latent genes protects human B cells from death by apoptosis.","volume":"349","author":"Gregory","year":"1991","journal-title":"Nature."},{"key":"2019111618274546100_B28","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1073\/pnas.90.6.2542","article-title":"Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization.","volume":"90","author":"Ramamoorthy","year":"1993","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2019111618274546100_B29","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1006\/cimm.1997.1205","article-title":"Mechanisms of antigen receptor-dependent apoptosis in human B lymphoma cell lines probed with a panel of 27 monoclonal antibodies.","volume":"182","author":"Grafton","year":"1997","journal-title":"Cell Immunol."},{"key":"2019111618274546100_B30","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0167-4889(92)90048-G","article-title":"Analysis and discrimination of necrosis and apoptosis (programmed cell death) by multiparameter flow cytometry.","volume":"1133","author":"Dive","year":"1992","journal-title":"Biochimica Biophysica Acta."},{"key":"2019111618274546100_B31","doi-asserted-by":"crossref","first-page":"58","DOI":"10.4049\/jimmunol.166.1.58","article-title":"Annexin V binds to positively selected B cells.","volume":"166","author":"Dillon","year":"2001","journal-title":"J Immunol."},{"key":"2019111618274546100_B32","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1006\/excr.1999.4581","article-title":"Annexin V staining due to loss of membrane asymmetry can be reversible and precede commitment to apoptotic death.","volume":"251","author":"Hammill","year":"1999","journal-title":"Exp Cell Res."},{"key":"2019111618274546100_B33","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1002\/eji.1830260604","article-title":"Death of germinal center B cells without DNA fragmentation.","volume":"26","author":"Nakamura","year":"1996","journal-title":"Eur J Immunol."},{"key":"2019111618274546100_B34","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/sj.leu.2402401","article-title":"T and B leukemic cell lines exhibit different requirements for cell death: correlation between caspase activation, DFF40\/DFF45 expression, DNA fragmentation and apoptosis in T cell lines but not in Burkitt's lymphoma.","volume":"16","author":"Luciano","year":"2002","journal-title":"Leukemia."},{"key":"2019111618274546100_B35","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1002\/eji.1830210819","article-title":"Germinal center cells express bcl-2 protein after activation by signals which prevent their entry to apoptosis.","volume":"21","author":"Liu","year":"1991","journal-title":"Eur J Immunol."},{"key":"2019111618274546100_B36","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/0092-8674(91)90007-L","article-title":"Induction of bcl-2 expression by Epstein-Barr virus latent membrane protein 1 protects infected B cells from programmed cell death.","volume":"65","author":"Henderson","year":"1991","journal-title":"Cell."},{"key":"2019111618274546100_B37","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1002\/ijc.2910520424","article-title":"Prevention of programmed cell death in Burkitt lymphoma cell lines by bcl-2-dependent and bcl-2-independent mechanisms.","volume":"52","author":"Milner","year":"1992","journal-title":"Int J Cancer."},{"key":"2019111618274546100_B38","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1023\/A:1009226316146","article-title":"The role of calcium in apoptosis.","volume":"11","author":"Krebs","year":"1998","journal-title":"Biometals."},{"key":"2019111618274546100_B39","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/S0028-3908(99)00206-3","article-title":"Inhibition of voltage-gated calcium channels by fluoxetine in rat hippocampal pyramidal cells.","volume":"38","author":"Deak","year":"2000","journal-title":"Neuropharmacology."},{"key":"2019111618274546100_B40","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1006\/phrs.2001.0810","article-title":"Effect of fluoxetine on intracellular Ca2+ levels in bladder female transitional carcinoma (BFTC) cells.","volume":"43","author":"Tang","year":"2001","journal-title":"Pharmacol Res."},{"key":"2019111618274546100_B41","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0014-2999(98)00955-8","article-title":"Inhibition by fluoxetine of voltage-activated ion channels in rat PC12 cells.","volume":"367","author":"Hahn","year":"1999","journal-title":"Eur J Pharmacol."},{"key":"2019111618274546100_B42","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s002100000337","article-title":"Fluoxetine-induced Ca2+ signals in Madin-Darby canine kidney cells.","volume":"363","author":"Tang","year":"2001","journal-title":"Naunyn Schmiedebergs Arch Pharmacol."},{"key":"2019111618274546100_B43","volume-title":"Clinical Pharmacology of Selective Serotonin Reuptake Inhibitors.","author":"Preskorn","year":"1996"},{"key":"2019111618274546100_B44","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1111\/j.1471-4159.1988.tb02479.x","article-title":"Characterization of [3H]paroxetine binding in rat brain.","volume":"50","author":"Marcusson","year":"1988","journal-title":"J Neurochem."},{"key":"2019111618274546100_B45","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/0140-6736(91)92513-2","article-title":"AIDS-associated non-Hodgkin lymphoma.","volume":"337","author":"Beral","year":"1991","journal-title":"Lancet."},{"key":"2019111618274546100_B46","doi-asserted-by":"crossref","first-page":"5871","DOI":"10.1523\/JNEUROSCI.21-16-05871.2001","article-title":"Mutations in the Caenorhabditis elegans serotonin reuptake transporter MOD-5 reveal serotonin-dependent and \u2013independent activities of fluoxetine.","volume":"21","author":"Ranganathan","year":"2001","journal-title":"J Neurosci."},{"key":"2019111618274546100_B47","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S1097-2765(00)80362-7","article-title":"Fluoxetine-resistant mutants in C. elegans define a novel family of transmembrane proteins.","volume":"4","author":"Choy","year":"1999","journal-title":"Mol Cell"},{"key":"2019111618274546100_B48","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1073\/pnas.94.5.2041","article-title":"Blockage of muscle and neuronal nicotinic acetylcholine receptors by fluoxetine (Prozac).","volume":"94","author":"Garcia-Colunga","year":"1997","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2019111618274546100_B49","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0167-4781(99)00139-6","article-title":"Human Bcl-2 antisense therapy for lymphomas.","volume":"1489","author":"Cotter","year":"1999","journal-title":"Biochim Biophys Acta."},{"key":"2019111618274546100_B50","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1176\/jnp.5.3.322","article-title":"Human brain fluoxetine concentrations.","volume":"5","author":"Karson","year":"1993","journal-title":"J Neuropsychiatry Clin Neurosci."},{"key":"2019111618274546100_B51","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/S0893-133X(00)00116-0","article-title":"Brain pharmacokinetics and tissue distribution in vivo of fluvoxamine and fluoxetine by fluorine magnetic resonance spectroscopy.","volume":"23","author":"Bolo","year":"2000","journal-title":"Neuropsychopharmacology."},{"key":"2019111618274546100_B52","doi-asserted-by":"crossref","first-page":"201","DOI":"10.2165\/00003088-199426030-00004","article-title":"Clinical pharmacokinetics of fluoxetine.","volume":"26","author":"Altamura","year":"1994","journal-title":"Clin Pharmacokinet."},{"key":"2019111618274546100_B53","first-page":"42","article-title":"SSRI safety in overdose.","volume":"59(suppl 15)","author":"Barbey","year":"1998","journal-title":"J Clin Psychiatry."},{"key":"2019111618274546100_B54","doi-asserted-by":"crossref","first-page":"3411","DOI":"10.1182\/blood.V99.9.3411","article-title":"Population depletion activates autonomous CD154-dependent survival in biopsy-like Burkitt's lymphoma cells.","volume":"99","author":"Challa","year":"2002","journal-title":"Blood."},{"key":"2019111618274546100_B55","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1006\/smim.1996.0029","article-title":"The huPBL-SCID mouse as a means to examine human immune function in vivo.","volume":"8","author":"Murphy","year":"1996","journal-title":"Semin Immunol."},{"key":"2019111618274546100_B56","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1084\/jem.192.8.1183","article-title":"Burkitt lymphoma in the mouse.","volume":"192","author":"Kovalchuk","year":"2000","journal-title":"J Exp Med."}],"container-title":["Blood"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/ashpublications.org\/blood\/article-pdf\/101\/8\/3212\/1262829\/h80803003212.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/ashpublications.org\/blood\/article-pdf\/101\/8\/3212\/1262829\/h80803003212.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,16]],"date-time":"2019-11-16T18:28:05Z","timestamp":1573928885000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/blood\/article\/101\/8\/3212\/16664\/Selective-serotonin-reuptake-inhibitors-directly"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,4,15]]},"references-count":56,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2003,4,15]]}},"URL":"https:\/\/doi.org\/10.1182\/blood-2002-07-2044","relation":{},"ISSN":["1528-0020","0006-4971"],"issn-type":[{"value":"1528-0020","type":"electronic"},{"value":"0006-4971","type":"print"}],"subject":[],"published":{"date-parts":[[2003,4,15]]}}}