{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T06:08:47Z","timestamp":1791094127486,"version":"4.1.0"},"reference-count":38,"publisher":"American Society of Hematology","issue":"4","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2003,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A defect in cell trafficking and chemotaxis plays an important role in the immune deficiency observed in Wiskott-Aldrich syndrome (WAS). In this report, we show that marrow cells from WAS protein (WASP)\u2013deficient mice also have a defect in chemotaxis. Serial transplantation and competitive reconstitution experiments demonstrated that marrow cells, including hematopoietic progenitors and stem cells (HSCs), have decreased homing capacities that were associated with a defect in adhesion to collagen. During development, HSCs migrate from the liver to the marrow and the spleen, prompting us to ask if a defect in HSC homing during development may explain the skewed X-chromosome inactivation in WAS carriers. Preliminary evidence has shown that, in contrast to marrow progenitor cells, fetal liver progenitor cells from heterozygous females had a random X-chromosome inactivation. When fetal liver cells from WASP-carrier females were injected into irradiated recipients, a nonrandom inactivation of the X-chromosome was found at the level of hematopoietic progenitors and HSCs responsible for the short- and long-term hematopoietic reconstitution. Therefore, the mechanism of the skewed X-chromosomal inactivation observed in WAS carriers may be related to a migration defect of WASP-deficient HSCs.<\/jats:p>","DOI":"10.1182\/blood-2002-07-2099","type":"journal-article","created":{"date-parts":[[2003,5,6]],"date-time":"2003-05-06T00:14:56Z","timestamp":1052180096000},"page":"1282-1289","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":62,"title":["A defect in hematopoietic stem cell migration explains the nonrandom X-chromosome inactivation in carriers of Wiskott-Aldrich syndrome"],"prefix":"10.1182","volume":"102","author":[{"given":"Catherine","family":"Lacout","sequence":"first","affiliation":[{"name":"From U362 Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM), Institut Gustave Roussy, Villejuif, France; Massachusetts General Hospital, Boston, MA; and INSERM U461, Faculte\u0301 de Pharmacie, Chatenay-Malabry, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elie","family":"Haddad","sequence":"additional","affiliation":[{"name":"From U362 Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM), Institut Gustave Roussy, Villejuif, France; Massachusetts General Hospital, Boston, MA; and INSERM U461, Faculte\u0301 de Pharmacie, Chatenay-Malabry, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siham","family":"Sabri","sequence":"additional","affiliation":[{"name":"From U362 Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM), Institut Gustave Roussy, Villejuif, France; Massachusetts General Hospital, Boston, MA; and INSERM U461, Faculte\u0301 de Pharmacie, Chatenay-Malabry, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fedor","family":"Svinarchouk","sequence":"additional","affiliation":[{"name":"From U362 Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM), Institut Gustave Roussy, Villejuif, France; Massachusetts General Hospital, Boston, MA; and INSERM U461, Faculte\u0301 de Pharmacie, Chatenay-Malabry, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loic","family":"Garc\u0327on","sequence":"additional","affiliation":[{"name":"From U362 Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM), Institut Gustave Roussy, Villejuif, France; Massachusetts General Hospital, Boston, MA; and INSERM U461, Faculte\u0301 de Pharmacie, Chatenay-Malabry, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Capron","sequence":"additional","affiliation":[{"name":"From U362 Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM), Institut Gustave Roussy, Villejuif, France; Massachusetts General Hospital, Boston, MA; and INSERM U461, Faculte\u0301 de Pharmacie, Chatenay-Malabry, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adlen","family":"Foudi","sequence":"additional","affiliation":[{"name":"From U362 Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM), Institut Gustave Roussy, Villejuif, France; Massachusetts General Hospital, Boston, MA; and INSERM U461, Faculte\u0301 de Pharmacie, Chatenay-Malabry, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rym","family":"Mzali","sequence":"additional","affiliation":[{"name":"From U362 Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM), Institut Gustave Roussy, Villejuif, France; Massachusetts General Hospital, Boston, MA; and INSERM U461, Faculte\u0301 de Pharmacie, Chatenay-Malabry, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott B.","family":"Snapper","sequence":"additional","affiliation":[{"name":"From U362 Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM), Institut Gustave Roussy, Villejuif, France; Massachusetts General Hospital, Boston, MA; and INSERM U461, Faculte\u0301 de Pharmacie, Chatenay-Malabry, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fawzia","family":"Louache","sequence":"additional","affiliation":[{"name":"From U362 Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM), Institut Gustave Roussy, Villejuif, France; Massachusetts General Hospital, Boston, MA; and INSERM U461, Faculte\u0301 de Pharmacie, Chatenay-Malabry, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Vainchenker","sequence":"additional","affiliation":[{"name":"From U362 Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM), Institut Gustave Roussy, Villejuif, France; Massachusetts General Hospital, Boston, MA; and INSERM U461, Faculte\u0301 de Pharmacie, Chatenay-Malabry, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Dume\u0301nil","sequence":"additional","affiliation":[{"name":"From U362 Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM), Institut Gustave Roussy, Villejuif, France; Massachusetts General Hospital, Boston, MA; and INSERM U461, Faculte\u0301 de Pharmacie, Chatenay-Malabry, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"key":"2020021219100986300_REF1","doi-asserted-by":"crossref","unstructured":"Sullivan KE. 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