{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:41:53Z","timestamp":1791286913012,"version":"4.1.0"},"reference-count":47,"publisher":"American Society of Hematology","issue":"7","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2003,4,1]]},"abstract":"<jats:p>The molecular markers that distinguish primary mediastinal large B-cell lymphoma (PMBL) from nonmediastinal diffuse large B-cell lymphomas (NM-DLBLs) remain to be identified. Using cDNA representational difference analysis to compare PMBL and NM-DLBL transcripts, we isolated a cDNA fragment homologous to the mouse B-cell interleukin 4 (IL-4)\u2013inducible gene FIG1(interleukin 4\u2013induced gene 1) transcript. The human FIG1mRNA encodes a 567 amino acid protein that comprises a signal peptide and a large flavin-binding amino oxidase domain, and shares significant homology with secreted apoptosis-inducing L-amino acid oxidases. Northern blot studies showed that FIG1 mRNA expression is mainly restricted to lymphoid tissues. It is expressed at low levels in thymus, spleen, tonsils, and reactive lymph nodes, and is highly up-regulated in IL-4+CD40\u2013activated tonsillar B cells. Interestingly, in human B-cell lines, FIG1 mRNA expression appeared restricted to the PMBL-derived MedB-1 and Karpas 1106 cell lines. Using real-time reverse transcriptase\u2013polymerase chain reaction (RT-PCR), we demonstrated that all but one PMBL (16\/17) displayed high FIG1 mRNA levels, whereas most NM-DLBLs (12\/18) and all low-grade B-cell lymphomas tested (8\/8) exhibited low FIG1 mRNA levels. The difference between PMBLs and NM-DLBLs was statistically significant (Fisher test;P\u2009=\u2009.0003). Southern blot studies did not show rearrangement of the FIG1 gene. FIG1 gene expression might be due to a constitutive activation of a cytokine signaling pathway in PMBL.<\/jats:p>","DOI":"10.1182\/blood-2002-07-2215","type":"journal-article","created":{"date-parts":[[2003,3,17]],"date-time":"2003-03-17T20:22:55Z","timestamp":1047932575000},"page":"2756-2761","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":69,"title":["Interleukin 4\u2013induced gene 1 is activated in primary mediastinal large B-cell lymphoma"],"prefix":"10.1182","volume":"101","author":[{"given":"Christiane","family":"Copie-Bergman","sequence":"first","affiliation":[{"name":"From the De\u0301partement de Pathologie, the Service d'Immunologie Biologique, and the Service d'He\u0301matologie Clinique, EA2348, AP-HP, Ho\u0302pital Henri Mondor, Cre\u0301teil, France; the Institute of Pathology, University of Ulm, Germany; the Department of Pathology, University of Leicester, United Kingdom; and the De\u0301partement d'He\u0301matologie of Institut Cochin, Maternite\u0301 Port-Royal, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Laure","family":"Boulland","sequence":"additional","affiliation":[{"name":"From the De\u0301partement de Pathologie, the Service d'Immunologie Biologique, and the Service d'He\u0301matologie Clinique, EA2348, AP-HP, Ho\u0302pital Henri Mondor, Cre\u0301teil, France; the Institute of Pathology, University of Ulm, Germany; the Department of Pathology, University of Leicester, United Kingdom; and the De\u0301partement d'He\u0301matologie of Institut Cochin, Maternite\u0301 Port-Royal, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Dehoulle","sequence":"additional","affiliation":[{"name":"From the De\u0301partement de Pathologie, the Service d'Immunologie Biologique, and the Service d'He\u0301matologie Clinique, EA2348, AP-HP, Ho\u0302pital Henri Mondor, Cre\u0301teil, France; the Institute of Pathology, University of Ulm, Germany; the Department of Pathology, University of Leicester, United Kingdom; and the De\u0301partement d'He\u0301matologie of Institut Cochin, Maternite\u0301 Port-Royal, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Mo\u0308ller","sequence":"additional","affiliation":[{"name":"From the De\u0301partement de Pathologie, the Service d'Immunologie Biologique, and the Service d'He\u0301matologie Clinique, EA2348, AP-HP, Ho\u0302pital Henri Mondor, Cre\u0301teil, France; the Institute of Pathology, University of Ulm, Germany; the Department of Pathology, University of Leicester, United Kingdom; and the De\u0301partement d'He\u0301matologie of Institut Cochin, Maternite\u0301 Port-Royal, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Farcet","sequence":"additional","affiliation":[{"name":"From the De\u0301partement de Pathologie, the Service d'Immunologie Biologique, and the Service d'He\u0301matologie Clinique, EA2348, AP-HP, Ho\u0302pital Henri Mondor, Cre\u0301teil, France; the Institute of Pathology, University of Ulm, Germany; the Department of Pathology, University of Leicester, United Kingdom; and the De\u0301partement d'He\u0301matologie of Institut Cochin, Maternite\u0301 Port-Royal, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin J. S.","family":"Dyer","sequence":"additional","affiliation":[{"name":"From the De\u0301partement de Pathologie, the Service d'Immunologie Biologique, and the Service d'He\u0301matologie Clinique, EA2348, AP-HP, Ho\u0302pital Henri Mondor, Cre\u0301teil, France; the Institute of Pathology, University of Ulm, Germany; the Department of Pathology, University of Leicester, United Kingdom; and the De\u0301partement d'He\u0301matologie of Institut Cochin, Maternite\u0301 Port-Royal, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Haioun","sequence":"additional","affiliation":[{"name":"From the De\u0301partement de Pathologie, the Service d'Immunologie Biologique, and the Service d'He\u0301matologie Clinique, EA2348, AP-HP, Ho\u0302pital Henri Mondor, Cre\u0301teil, France; the Institute of Pathology, University of Ulm, Germany; the Department of Pathology, University of Leicester, United Kingdom; and the De\u0301partement d'He\u0301matologie of Institut Cochin, Maternite\u0301 Port-Royal, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul-Henri","family":"Rome\u0301o","sequence":"additional","affiliation":[{"name":"From the De\u0301partement de Pathologie, the Service d'Immunologie Biologique, and the Service d'He\u0301matologie Clinique, EA2348, AP-HP, Ho\u0302pital Henri Mondor, Cre\u0301teil, France; the Institute of Pathology, University of Ulm, Germany; the Department of Pathology, University of Leicester, United Kingdom; and the De\u0301partement d'He\u0301matologie of Institut Cochin, Maternite\u0301 Port-Royal, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Gaulard","sequence":"additional","affiliation":[{"name":"From the De\u0301partement de Pathologie, the Service d'Immunologie Biologique, and the Service d'He\u0301matologie Clinique, EA2348, AP-HP, Ho\u0302pital Henri Mondor, Cre\u0301teil, France; the Institute of Pathology, University of Ulm, Germany; the Department of Pathology, University of Leicester, United Kingdom; and the De\u0301partement d'He\u0301matologie of Institut Cochin, Maternite\u0301 Port-Royal, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Leroy","sequence":"additional","affiliation":[{"name":"From the De\u0301partement de Pathologie, the Service d'Immunologie Biologique, and the Service d'He\u0301matologie Clinique, EA2348, AP-HP, Ho\u0302pital Henri Mondor, Cre\u0301teil, France; the Institute of Pathology, University of Ulm, Germany; the Department of Pathology, University of Leicester, United Kingdom; and the De\u0301partement d'He\u0301matologie of Institut Cochin, Maternite\u0301 Port-Royal, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"key":"2019111821595325100_B1","volume-title":"World Health Organization Classification of Tumours. 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