{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:56:40Z","timestamp":1792587400332,"version":"4.5.0"},"reference-count":66,"publisher":"American Society of Hematology","issue":"7","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2003,4,1]]},"abstract":"<jats:p>T-acute lymphoblastic leukemias (T-ALLs) derive from human T-lymphoid precursors arrested at various early stages of development. Correlation of phenotype and T-cell receptor (TCR) status with RAG-1 and pT\u03b1 transcription in 114 T-ALLs demonstrated that they largely reflect physiologic T-lymphoid development. Half the TCR\u03b1\u03b2 lineage T-ALLs expressed a pre-TCR, as evidenced by RAG-1, pT\u03b1, and cTCR\u03b2 expression, absence of TCR\u03b4 deletion, and a sCD3\u2212, CD1a+, CD4\/8 double-positive (DP) phenotype, in keeping with a population undergoing \u03b2 selection. Most TCR\u03b3\u03b4 T-ALLs were pT\u03b1, terminal deoxynucleotidyl transferase (TdT), and RAG-1lo\/neg, double-negative\/single-positive (DN\/SP), and demonstrated only TCR\u03b2 DJ rearrangement, whereas 40% were pT\u03b1, TdT, and RAG-1 positive, DP, and demonstrated TCR\u03b2 V(D)J rearrangement, with cTCR\u03b2 expression in proportion. As such they may correspond to TCR\u03b1\u03b2 lineage precursors selected by TCR\u03b3\u03b4 expression, to early \u03b3\u03b4 cells recently derived from a pT\u03b1+ common \u03b1\u03b2\/\u03b3\u03b4 precursor, or to a lineage-deregulated \u03b1\u03b2\/\u03b3\u03b4 intermediate. Approximately 30% of T-ALLs were sCD3\/cTCR\u03b2\u2212 and corresponded to nonrestricted thymic precursors because they expressed non\u2013T-restricted markers such as CD34, CD13, CD33, and CD56 and were predominantly DN, CD1a, pT\u03b1, and RAG-1 low\/negative, despite immature TCR\u03b4 and TCR\u03b3 rearrangements. TCR gene configuration identified progressive T-lymphoid restriction. T-ALLs, therefore, provide homogeneous expansions of minor human lymphoid precursor populations that can aid in the understanding of healthy human T-cell development.<\/jats:p>","DOI":"10.1182\/blood-2002-08-2438","type":"journal-article","created":{"date-parts":[[2003,3,17]],"date-time":"2003-03-17T20:22:55Z","timestamp":1047932575000},"page":"2693-2703","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":179,"title":["Analysis of TCR, pT\u03b1, and RAG-1 in T-acute lymphoblastic leukemias improves understanding of early human T-lymphoid lineage commitment"],"prefix":"10.1182","volume":"101","author":[{"given":"Vahid","family":"Asnafi","sequence":"first","affiliation":[{"name":"From the Department of Biological and Clinical Hematology, Centre Hospitalier-Universitaire\/Assistance Publique-Hopitaux de Paris (CHU\/AP-HP) Necker-Enfants Malades and Universite\u0301 Paris V; Ho\u0302pital Bretonneau, Tours; Ho\u0302pital La 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