{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T20:58:24Z","timestamp":1791147504267,"version":"4.1.0"},"reference-count":59,"publisher":"American Society of Hematology","issue":"10","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2003,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In mice, interleukin-7 (IL-7) hastens T-cell reconstitution and might cause autoimmune diseases, lymphoma, and osteoporosis. We assessed the effect of IL-7 on T-cell reconstitution and toxicity in baboons that underwent total body irradiation followed by autologous transplantation of marrow CD34 cells. Three baboons received placebo and 3 baboons received recombinant human IL-7 (rhIL-7, 75 \u03bcg\/kg twice a day subcutaneously) between 6 and 10 weeks after transplantation. The mean increase in blood absolute CD4 T-cell counts was 0.9-fold in the placebo-treated animals versus 9.0-fold in those treated with IL-7 (P\u2009=\u2009.02). The increase observed in the IL-7\u2013treated animals appeared attributable to peripheral expansion rather than de novo generation. The IL-7\u2013treated animals had greater mean increases in the volumes of the spleen (2.0-fold with placebo versus 4.5-fold with IL-7, P\u2009=\u2009.02) and lymph nodes (1.8-fold with placebo versus 4.1-fold with IL-7,P\u2009=\u2009.10) but not the thymus (3.4-fold with placebo versus 1.1-fold with IL-7, P\u2009=\u2009.18). Side effects of IL-7 included thrombocytopenia and possibly neutropenia and hemolytic anemia. One IL-7\u2013treated animal failed to thrive due to a disease resembling graft-versus-host disease. No animals developed lymphoma. Bone density was not decreased. In conclusion, IL-7 raises CD4 T-cell counts in irradiated primates. It remains to be determined whether this is associated with clinical benefit.<\/jats:p>","DOI":"10.1182\/blood-2002-08-2671","type":"journal-article","created":{"date-parts":[[2003,5,5]],"date-time":"2003-05-05T19:24:00Z","timestamp":1052162640000},"page":"4209-4218","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":65,"title":["Interleukin-7 improves CD4 T-cell reconstitution after autologous CD34 cell transplantation in monkeys"],"prefix":"10.1182","volume":"101","author":[{"given":"Jan","family":"Storek","sequence":"first","affiliation":[{"name":"From the Fred Hutchinson Cancer Research Center (FHCRC), Seattle, WA, and University of Washington, Seattle."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Thurman","family":"Gillespy","sequence":"additional","affiliation":[{"name":"From the Fred Hutchinson Cancer Research Center (FHCRC), Seattle, WA, and University of Washington, 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