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We recently described an in vitro model making it possible to obtain a large number of cells with the morphologic, phenotypic, and functional characteristics of normal polyclonal plasmablastic cells (PPCs). Using Affymetrix microarrays we compared the gene expression profiles of these PPCs with those of mature PCs isolated from tonsils (TPCs) and bone marrow (BMPCs), and with those of B cells purified from peripheral blood (PBB cells) and tonsils (TBCs). Unsupervised principal component analysis clearly distinguished the 5 cell populations on the basis of their differentiation and proliferation status. Detailed statistical analysis allowed the identification of 85 PC genes and 40 B-cell genes, overexpressed, respectively, in the 3 PC subsets or in the 2 B-cell subsets. In addition, several signaling molecules and antiapoptotic proteins were found to be induced in BMPCs compared with PPCs and could be involved in the accumulation and prolonged survival of BMPCs in close contact with specialized stromal microenvironment. These data should help to better understand the molecular events that regulate commitment to a PC fate, mediate PC maintenance in survival niches, and could facilitate PC immortalization in plasma cell dyscrasias.<\/jats:p>","DOI":"10.1182\/blood-2002-10-3161","type":"journal-article","created":{"date-parts":[[2003,4,1]],"date-time":"2003-04-01T01:26:35Z","timestamp":1049160395000},"page":"592-600","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":185,"title":["Gene expression profiling of plasma cells and plasmablasts: toward a better understanding of the late stages of B-cell differentiation"],"prefix":"10.1182","volume":"102","author":[{"given":"Karin","family":"Tarte","sequence":"first","affiliation":[{"name":"From the Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) U475, Montpellier, France; Unite\u0301 de The\u0301rapie Cellulaire, Centre Hospitalier Universitaire (CHU) Montpellier, Ho\u0302pital Saint Eloi, Montpellier, France; and the Donna and Donald Lambert Laboratory of Myeloma Genetics, Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenghuang","family":"Zhan","sequence":"additional","affiliation":[{"name":"From the Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) U475, Montpellier, France; Unite\u0301 de The\u0301rapie Cellulaire, Centre Hospitalier Universitaire (CHU) Montpellier, Ho\u0302pital Saint Eloi, Montpellier, France; and the Donna and Donald Lambert Laboratory of Myeloma Genetics, Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"De Vos","sequence":"additional","affiliation":[{"name":"From the Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) U475, Montpellier, France; Unite\u0301 de The\u0301rapie Cellulaire, Centre Hospitalier Universitaire (CHU) Montpellier, Ho\u0302pital Saint Eloi, Montpellier, France; and the Donna and Donald Lambert Laboratory of Myeloma Genetics, Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Klein","sequence":"additional","affiliation":[{"name":"From the Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) U475, Montpellier, France; Unite\u0301 de The\u0301rapie Cellulaire, Centre Hospitalier Universitaire (CHU) Montpellier, Ho\u0302pital Saint Eloi, Montpellier, France; and the Donna and Donald Lambert Laboratory of Myeloma Genetics, Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"John","family":"Shaughnessy","sequence":"additional","affiliation":[{"name":"From the Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) U475, Montpellier, France; Unite\u0301 de The\u0301rapie Cellulaire, Centre Hospitalier Universitaire (CHU) Montpellier, Ho\u0302pital Saint Eloi, Montpellier, France; and the Donna and Donald Lambert Laboratory of Myeloma Genetics, Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"key":"2020021300101473600_REF1","doi-asserted-by":"crossref","unstructured":"Slifka MK, Antia R, Whitmire JK, Ahmed R. 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