{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:15:33Z","timestamp":1792512933519,"version":"4.5.0"},"reference-count":60,"publisher":"American Society of Hematology","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Blood"],"published-print":{"date-parts":[[2003,4,15]]},"DOI":"10.1182\/blood-2002-10-3296","type":"journal-article","created":{"date-parts":[[2003,4,2]],"date-time":"2003-04-02T13:43:59Z","timestamp":1049291039000},"page":"2963-2972","source":"Crossref","is-referenced-by-count":612,"title":["AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe hemophilia B"],"prefix":"10.1182","volume":"101","author":[{"given":"C. S.","family":"Manno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. J.","family":"Chew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Hutchison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. J.","family":"Larson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. W.","family":"Herzog","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. R.","family":"Arruda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. J.","family":"Tai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. V.","family":"Ragni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ozelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. B.","family":"Couto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. G. B.","family":"Leonard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. A.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"McClelland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Scallan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Skarsgard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. W.","family":"Flake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Kay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. A.","family":"High","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Glader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"issue":"2","key":"1_6022363","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1046\/j.1365-2141.1998.00707.x","volume":"101","author":"Ljung","year":"1998","journal-title":"British journal of haematology","ISSN":"https:\/\/id.crossref.org\/issn\/0007-1048","issn-type":"print"},{"issue":"6","key":"3_21312703","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1182\/blood.V51.6.1179.1179","volume":"51","author":"Eyster","year":"1978","journal-title":"Blood","ISSN":"https:\/\/id.crossref.org\/issn\/0006-4971","issn-type":"print"},{"issue":"10","key":"4_13332093","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.1001\/archinte.1984.04400010093017","volume":"144","author":"Andes","year":"1984","journal-title":"Archives of Internal Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0003-9926","issn-type":"print"},{"issue":"11","key":"5_20132349","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1001\/archpedi.1987.04460110085030","volume":"141","author":"Bray","year":"1987","journal-title":"Archives of Pediatrics and Adolescent Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0096-8994","issn-type":"print"},{"issue":"2","key":"6_21329457","first-page":"437","volume":"96","author":"Soucie","year":"2000","journal-title":"Blood","ISSN":"https:\/\/id.crossref.org\/issn\/0006-4971","issn-type":"print"},{"issue":"5","key":"7_16809127","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1046\/j.1365-2796.1997.130135000.x","volume":"241","author":"L\u00a0\u00a0fqvist","year":"1997","journal-title":"Journal of internal medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0954-6820","issn-type":"print"},{"issue":"1","key":"8_21329887","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1182\/blood.V97.1.130","volume":"97","author":"Arruda","year":"2001","journal-title":"Blood","ISSN":"https:\/\/id.crossref.org\/issn\/0006-4971","issn-type":"print"},{"issue":"2 Suppl 2","key":"9_5978935","first-page":"11","volume":"35","author":"Bond","year":"1998","journal-title":"Seminars in hematology","ISSN":"https:\/\/id.crossref.org\/issn\/0037-1963","issn-type":"print"},{"issue":"1","key":"10_21326944","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1182\/blood.V92.1.168.413k06_168_174","volume":"92","author":"Kundu","year":"1998","journal-title":"Blood","ISSN":"https:\/\/id.crossref.org\/issn\/0006-4971","issn-type":"print"},{"issue":"1","key":"11_15980165","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1038\/ng0595-119","volume":"10","author":"Bi","year":"1995","journal-title":"Nature genetics","ISSN":"https:\/\/id.crossref.org\/issn\/1061-4036","issn-type":"print"},{"issue":"10","key":"12_21325792","doi-asserted-by":"crossref","first-page":"3962","DOI":"10.1182\/blood.V90.10.3962","volume":"90","author":"Lin","year":"1997","journal-title":"Blood","ISSN":"https:\/\/id.crossref.org\/issn\/0006-4971","issn-type":"print"},{"issue":"21","key":"13_5761128","doi-asserted-by":"publisher","first-page":"11563","DOI":"10.1073\/pnas.94.21.11563","volume":"94","author":"Wang","year":"1997","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"1","key":"14_21317683","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1182\/blood.V74.1.207.207","volume":"74","author":"Evans","year":"1989","journal-title":"Blood","ISSN":"https:\/\/id.crossref.org\/issn\/0006-4971","issn-type":"print"},{"issue":"2","key":"15_5910679","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1055\/s-0037-1614984","volume":"79","author":"Cameron","year":"1998","journal-title":"Thrombosis and haemostasis","ISSN":"https:\/\/id.crossref.org\/issn\/0340-6245","issn-type":"print"},{"issue":"9","key":"16_21325101","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.1182\/blood.V88.9.3451.bloodjournal8893451","volume":"88","author":"Mauser","year":"1996","journal-title":"Blood","ISSN":"https:\/\/id.crossref.org\/issn\/0006-4971","issn-type":"print"},{"issue":"11","key":"17_16486061","doi-asserted-by":"crossref","first-page":"8098","DOI":"10.1128\/JVI.70.11.8098-8108.1996","volume":"70","author":"Xiao","year":"1996","journal-title":"Journal of Virology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-538X","issn-type":"print"},{"issue":"4","key":"18_16692419","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.1073\/pnas.94.4.1426","volume":"94","author":"Koeberl","year":"1997","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"24","key":"19_16535902","doi-asserted-by":"publisher","first-page":"14082","DOI":"10.1073\/pnas.93.24.14082","volume":"93","author":"Kessler","year":"1996","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"2","key":"20_15752220","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1038\/ng1094-148","volume":"8","author":"Kaplitt","year":"1994","journal-title":"Nature genetics","ISSN":"https:\/\/id.crossref.org\/issn\/1061-4036","issn-type":"print"},{"issue":"3","key":"21_16832251","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/ng0797-270","volume":"16","author":"Snyder","year":"1997","journal-title":"Nature genetics","ISSN":"https:\/\/id.crossref.org\/issn\/1061-4036","issn-type":"print"},{"issue":"11","key":"22_16787969","doi-asserted-by":"publisher","first-page":"5804","DOI":"10.1073\/pnas.94.11.5804","volume":"94","author":"Herzog","year":"1997","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"1","key":"23_10705625","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/4743","volume":"5","author":"Herzog","year":"1999","journal-title":"Nature medicine","ISSN":"https:\/\/id.crossref.org\/issn\/1078-8956","issn-type":"print"},{"issue":"3","key":"24_6493703","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1038\/73464","volume":"24","author":"Kay","year":"2000","journal-title":"Nature genetics","ISSN":"https:\/\/id.crossref.org\/issn\/1061-4036","issn-type":"print"},{"issue":"10","key":"25_15804479","doi-asserted-by":"publisher","first-page":"5276","DOI":"10.1074\/jbc.270.10.5276","volume":"270","author":"Hitomi","year":"1995","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"7","key":"26_6227390","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1038\/sj.gt.3300680","volume":"5","author":"Matsushita","year":"1998","journal-title":"Gene therapy","ISSN":"https:\/\/id.crossref.org\/issn\/0969-7128","issn-type":"print"},{"issue":"11","key":"28_17181174","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1089\/104303402760128513","volume":"13","author":"Herzog","year":"2002","journal-title":"Human gene therapy","ISSN":"https:\/\/id.crossref.org\/issn\/1043-0342","issn-type":"print"},{"key":"29_46023033","first-page":"9","volume":"9","year":"1989","journal-title":"MOLECULAR CLONING"},{"issue":"4","key":"30_6514776","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1089\/10430340050015716","volume":"11","author":"Pruchnic","year":"2000","journal-title":"Human gene therapy","ISSN":"https:\/\/id.crossref.org\/issn\/1043-0342","issn-type":"print"},{"issue":"2","key":"31_5866556","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1128\/JVI.72.2.1438-1445.1998","volume":"72","author":"Summerford","year":"1998","journal-title":"Journal of Virology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-538X","issn-type":"print"},{"issue":"1","key":"32_12426686","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/0022-510X(73)90023-3","volume":"18","author":"Johnson","year":"1973","journal-title":"Journal of the neurological sciences","ISSN":"https:\/\/id.crossref.org\/issn\/0022-510X","issn-type":"print"},{"issue":"12","key":"33_21326501","doi-asserted-by":"crossref","first-page":"4600","DOI":"10.1182\/blood.V91.12.4600","volume":"91","author":"Nakai","year":"1998","journal-title":"Blood","ISSN":"https:\/\/id.crossref.org\/issn\/0006-4971","issn-type":"print"},{"issue":"1","key":"34_10705626","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1038\/4751","volume":"5","author":"Snyder","year":"1999","journal-title":"Nature medicine","ISSN":"https:\/\/id.crossref.org\/issn\/1078-8956","issn-type":"print"},{"issue":"6","key":"35_5994324","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1089\/hum.1998.9.6-889","volume":"9","author":"Wagner","year":"1998","journal-title":"Human gene therapy","ISSN":"https:\/\/id.crossref.org\/issn\/1043-0342","issn-type":"print"},{"issue":"2","key":"36_16498678","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1046\/j.1365-2141.1996.d01-1899.x","volume":"95","author":"Ahmed","year":"1996","journal-title":"British journal of haematology","ISSN":"https:\/\/id.crossref.org\/issn\/0007-1048","issn-type":"print"},{"issue":"2","key":"37_21315383","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1182\/blood.V66.2.367.367","volume":"66","author":"Aledort","year":"1985","journal-title":"Blood","ISSN":"https:\/\/id.crossref.org\/issn\/0006-4971","issn-type":"print"},{"issue":"1","key":"38_16303023","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1046\/j.1365-2141.1996.6192064.x","volume":"94","author":"Hanley","year":"1996","journal-title":"British journal of haematology","ISSN":"https:\/\/id.crossref.org\/issn\/0007-1048","issn-type":"print"},{"issue":"6","key":"39_11434394","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1006\/mthe.2001.0491","volume":"4","author":"Arruda","year":"2001","journal-title":"Molecular therapy : the journal of the American Society of Gene Therapy","ISSN":"https:\/\/id.crossref.org\/issn\/1525-0016","issn-type":"print"},{"issue":"3","key":"40_10756659","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/6429","volume":"5","year":"1999","journal-title":"Nature medicine","ISSN":"https:\/\/id.crossref.org\/issn\/1078-8956","issn-type":"print"},{"issue":"4","key":"41_10915498","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1038\/11895","volume":"22","author":"Epstein","year":"1999","journal-title":"Nature genetics","ISSN":"https:\/\/id.crossref.org\/issn\/1061-4036","issn-type":"print"},{"issue":"6865","key":"43_11447693","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/414677a","volume":"414","author":"Boyce","year":"2001","journal-title":"Nature; Physical Science (London)","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"issue":"7","key":"46_10769120","doi-asserted-by":"publisher","first-page":"3906","DOI":"10.1073\/pnas.96.7.3906","volume":"96","author":"Wang","year":"1999","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"2","key":"47_10431538","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1006\/mthe.2000.0031","volume":"1","author":"Wang","year":"2000","journal-title":"Molecular therapy : the journal of the American Society of Gene Therapy","ISSN":"https:\/\/id.crossref.org\/issn\/1525-0016","issn-type":"print"},{"issue":"8","key":"48_21331638","doi-asserted-by":"publisher","first-page":"2670","DOI":"10.1182\/blood.V99.8.2670","volume":"99","author":"Mount","year":"2002","journal-title":"Blood","ISSN":"https:\/\/id.crossref.org\/issn\/0006-4971","issn-type":"print"},{"issue":"7","key":"49_10107074","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1056\/NEJM199302183280701","volume":"328","author":"Lusher","year":"1993","journal-title":"New England Journal of Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"issue":"9","key":"50_21322116","first-page":"2428","volume":"83","author":"Bray","year":"1994","journal-title":"Blood","ISSN":"https:\/\/id.crossref.org\/issn\/0006-4971","issn-type":"print"},{"key":"52_46023034","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1006\/mthe.2000.0032","volume":"1","year":"2000","journal-title":"MOLE THER"},{"issue":"18","key":"53_10947200","doi-asserted-by":"publisher","first-page":"9973","DOI":"10.1073\/pnas.96.18.9973","volume":"96","author":"Kay","year":"1999","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"3","key":"54_11311137","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1006\/mthe.2001.0442","volume":"4","author":"Herzog","year":"2001","journal-title":"Molecular therapy : the journal of the American Society of Gene Therapy","ISSN":"https:\/\/id.crossref.org\/issn\/1525-0016","issn-type":"print"},{"issue":"4","key":"55_9695251","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1097\/00001721-199108000-00007","volume":"2","author":"Green","year":"1991","journal-title":"Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis","ISSN":"https:\/\/id.crossref.org\/issn\/0957-5235","issn-type":"print"},{"issue":"9","key":"56_10969491","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1038\/sj.gt.3300994","volume":"6","author":"Chirmule","year":"1999","journal-title":"Gene therapy","ISSN":"https:\/\/id.crossref.org\/issn\/0969-7128","issn-type":"print"},{"issue":"3","key":"57_16707401","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1038\/nm0397-306","volume":"3","author":"Fisher","year":"1997","journal-title":"Nature medicine","ISSN":"https:\/\/id.crossref.org\/issn\/1078-8956","issn-type":"print"},{"key":"58_24137829","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1006\/mthe.2000.0147","volume":"1","year":"2000","journal-title":"Molecular therapy : the journal of the American Society of Gene Therapy","ISSN":"https:\/\/id.crossref.org\/issn\/1525-0016","issn-type":"print"},{"issue":"5","key":"59_10780752","doi-asserted-by":"crossref","first-page":"3994","DOI":"10.1128\/JVI.73.5.3994-4003.1999","volume":"73","author":"Xiao","year":"1999","journal-title":"Journal of Virology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-538X","issn-type":"print"},{"issue":"6","key":"60_10585741","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1006\/mthe.2000.0219","volume":"2","author":"Chao","year":"2000","journal-title":"Molecular therapy : the journal of the American Society of Gene Therapy","ISSN":"https:\/\/id.crossref.org\/issn\/1525-0016","issn-type":"print"},{"issue":"3","key":"62_16976345","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1055\/s-0037-1613023","volume":"87","author":"Shima","year":"2002","journal-title":"Thrombosis and haemostasis","ISSN":"https:\/\/id.crossref.org\/issn\/0340-6245","issn-type":"print"},{"key":"63_46023035","first-page":"418b","volume":"90(suppl)","year":"1997","journal-title":"Blood","ISSN":"https:\/\/id.crossref.org\/issn\/0006-4971","issn-type":"print"},{"issue":"5","key":"64_6543742","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1089\/10430340050015671","volume":"11","author":"Stedman","year":"2000","journal-title":"Human gene therapy","ISSN":"https:\/\/id.crossref.org\/issn\/1043-0342","issn-type":"print"},{"issue":"9","key":"65_21329201","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1182\/blood.V95.9.2793.009k07_2793_2798","volume":"95","author":"Bohl","year":"2000","journal-title":"Blood","ISSN":"https:\/\/id.crossref.org\/issn\/0006-4971","issn-type":"print"},{"issue":"2","key":"66_11040708","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1006\/jmcc.2000.1301","volume":"33","author":"Byun","year":"2001","journal-title":"Journal of molecular and cellular cardiology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-2828","issn-type":"print"},{"issue":"6","key":"67_11434391","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1006\/mthe.2001.0494","volume":"4","author":"Favre","year":"2001","journal-title":"Molecular therapy : the journal of the American Society of Gene Therapy","ISSN":"https:\/\/id.crossref.org\/issn\/1525-0016","issn-type":"print"}],"container-title":["Blood"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1182\/blood-2002-10-3296","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T18:12:55Z","timestamp":1583950375000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.bloodjournal.org\/cgi\/doi\/10.1182\/blood-2002-10-3296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,4,15]]},"references-count":60,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2003,4,15]]}},"URL":"https:\/\/doi.org\/10.1182\/blood-2002-10-3296","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.12856956.14144054","asserted-by":"object"}]},"ISSN":["0006-4971","1528-0020"],"issn-type":[{"value":"0006-4971","type":"print"},{"value":"1528-0020","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,4,15]]}}}