{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T15:41:50Z","timestamp":1794670910857,"version":"4.9.1"},"reference-count":29,"publisher":"American Society of Hematology","issue":"13","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2003,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Numerous studies have examined the outcomes of infants born to mothers with idiopathic thrombocytopenic purpura (ITP). Fewer studies have discussed the morbidity of obstetric patients with ITP. We describe a retrospective study of 92 women with ITP during 119 pregnancies over an 11-year period. Most women had thrombocytopenia during pregnancy. At delivery, women in 98 pregnancies (89%) had platelet counts lower than 150 \u00d7 109\/L; most had mild to moderate thrombocytopenia. For many, the pregnancy was uneventful; however, women had moderate to severe bleeding in 25 pregnancies (21.5%). Women in 37 pregnancies (31.1%) required treatment to increase platelet counts. During delivery, 44 women (37.3%) received epidural analgesia without complications, with most having a platelet count between 50 and 149 \u00d7 109\/L. Most deliveries (82.4%) were vaginal. Bleeding was uncommon at delivery. Infant platelet counts at birth ranged from 12 to 436 \u00d7 109\/L; 25.2% of infants had platelet counts lower than 150 \u00d7 109\/L, and 9% had platelet counts lower than 50 \u00d7 109\/L. Eighteen infants (14.6%) required treatment for hemostatic impairment. Two fetal deaths occurred. One was caused by hemorrhage. ITP in pregnancy carries a low risk, but mothers and infants may require therapy to raise their platelet counts. (Blood. 2003;102:4306-4311)<\/jats:p>","DOI":"10.1182\/blood-2002-10-3317","type":"journal-article","created":{"date-parts":[[2003,9,2]],"date-time":"2003-09-02T00:41:59Z","timestamp":1062463319000},"page":"4306-4311","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":246,"title":["A retrospective 11-year analysis of obstetric patients with idiopathic thrombocytopenic purpura"],"prefix":"10.1182","volume":"102","author":[{"given":"Kathryn E.","family":"Webert","sequence":"first","affiliation":[{"name":"From the Department of Medicine, McMaster University, Hamilton, Ontario, ON, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richa","family":"Mittal","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, McMaster University, Hamilton, Ontario, ON, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Sigouin","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, McMaster University, Hamilton, Ontario, ON, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy M.","family":"Heddle","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, McMaster University, Hamilton, Ontario, ON, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.","family":"Kelton","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, McMaster University, Hamilton, Ontario, ON, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"key":"2020021223270658100_REF1","doi-asserted-by":"crossref","unstructured":"Crowther MA, Burrows RF, Ginsberg J, Kelton JG. 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